Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
GUJMYVJMSZASKI
|
7.7 | IC50 | 3 | — | |
ZCWXCBKGPJOAFQ
|
7.7 | IC50 | 13 | — | |
AIEPQAYTYHKSAX
|
7.7 | IC50 | 3 | — | |
FGTCROZDHDSNIO
|
7.7 | IC50 | 5 | — | |
KWEMJZWHNJCGCV
|
7.7 | IC50 | 3 | — | |
MCRPCXDVVXVUKA
|
7.7 | IC50 | 3 | — | |
PQXQJSMNKNNINY
|
7.7 | IC50 | 2 | — | |
PTPSYWCHGKIOKO
|
7.7 | IC50 | 3 | — | |
SXBGVYYYZFBEKG
|
7.7 | IC50 | 2 | — | |
WLKGPIPZNVLVAM
|
7.7 | IC50 | 4 | — | |
XYFZVVYVIFJBIS
|
7.7 | IC50 | 17 | — | |
XYWFZNZTTHKFPM
|
7.7 | IC50 | 3 | — | |
ZUJPITIYCZFUQQ
|
7.7 | IC50 | 3 | — | |
FITNUKNIUJHPPH
|
7.7 | IC50 | 5 | Yes | |
GUJMYVJMSZASKI
|
7.7 | IC50 | 3 | — | |
KWEMJZWHNJCGCV
|
7.7 | IC50 | 3 | — | |
UJEQWHRLDYTMPE
|
7.7 | IC50 | 3 | — | |
VKGKEHUDLZDBMP
|
7.7 | IC50 | 5 | Yes | |
ZLUFMEFGLIZOAP
|
7.7 | IC50 | 3 | — | |
ATAXRSLEVBMIFF
|
7.6 | IC50 | 2 | Yes | |
FUKNUNMDYLHWDX
|
7.6 | IC50 | 3 | — | |
JHZHLPIBCPQAJX
|
7.6 | IC50 | 4 | Yes | |
OZWSLBMKAZOPGU
|
7.6 | IC50 | 3 | — | |
PJABFBSDQOHWAG
|
7.6 | IC50 | 3 | — | |
QPSCCNWGOLMGKW
|
7.6 | IC50 | 4 | Yes | |
QXDWLMJUKFRTHN
|
7.6 | IC50 | 3 | — | |
SRDCKXVGOFJLJK
|
7.6 | IC50 | 3 | Yes | |
UOJUQBSCCIRCHS
|
7.6 | IC50 | 4 | Yes | |
UPABYWZSQBEEII
|
7.6 | IC50 | 6 | Yes | |
UYRBVTHOEONXLM
|
7.6 | IC50 | 3 | — | |
AZVYFUSSBQUDOU
|
7.6 | IC50 | 3 | — | |
JJMCEWIEMJDKKW
|
7.6 | IC50 | 3 | — | |
KHUHMPCMKSWRNR
|
7.6 | IC50 | 3 | — | |
LBYXRPIRNUXBME
|
7.6 | IC50 | 3 | — | |
QMTYIXIBNREJSV
|
7.6 | IC50 | 3 | — | |
RCFMYOVNMVCRHQ
|
7.6 | IC50 | 5 | Yes | |
RETBYBLRWLXQHI
|
7.6 | IC50 | 2 | — | |
WWXRVDUEBRGDFI
|
7.6 | IC50 | 3 | — | |
HKSZLNNOFSGOKW
|
7.6 | Ki | 118 | — | |
JDNWHCLQTRJTAJ
|
7.6 | IC50 | 6 | Yes | |
KKYPRNBBPBRJQX
|
7.6 | Ki | 40 | — | |
PLJFMBJRCTXQIB
|
7.6 | IC50 | 3 | — | |
YSIGPHXBCCDXSF
|
7.6 | IC50 | 3 | — | |
QWEKIGQOBHAQDZ
|
7.6 | IC50 | 3 | — | |
AIKGYQDFIJRQIY
|
7.6 | IC50 | 9 | — | |
DEGODTVDGRTRCG
|
7.6 | IC50 | 2 | — | |
IQTVWALDAQLAGA
|
7.6 | IC50 | 3 | — | |
OMIQRSKHABIPRH
|
7.6 | IC50 | 15 | — | |
PISGPHDAGMGMKC
|
7.6 | IC50 | 3 | — | |
ZMDAIGKVAJVTEG
|
7.6 | IC50 | 3 | — |