Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NPSXOCPQKKCBFX
|
7.8 | IC50 | 3 | Yes | |
OZWSLBMKAZOPGU
|
7.8 | IC50 | 3 | — | |
RGCNFAMRCLHNFW
|
7.8 | IC50 | 3 | — | |
SVXLGFPJMGBRRR
|
7.8 | IC50 | 3 | — | |
OUQCWTKXHVIBQY
|
7.8 | IC50 | 3 | — | |
DJNWXYTWORPJNI
|
7.7 | IC50 | 4 | Yes | |
TVHNCWLRUOTUCD
|
7.7 | IC50 | 2 | — | |
WHOHIBXOMRSQNS
|
7.7 | IC50 | 3 | — | |
ZQUSFAUAYSEREK
|
7.7 | IC50 | 9 | Yes | |
FUKNUNMDYLHWDX
|
7.7 | IC50 | 3 | — | |
JNCFZEVZRYWROV
|
7.7 | IC50 | 3 | — | |
PJLNANCIFHCOOI
|
7.7 | IC50 | 3 | — | |
ZVIKAJOZJVAHPH
|
7.7 | IC50 | 5 | Yes | |
AIAOQIKSQNONHC
|
7.7 | IC50 | 3 | — | |
CEIYRBYXRSULDG
|
7.7 | IC50 | 4 | Yes | |
DWUWREPGQDQGAG
|
7.7 | IC50 | 3 | — | |
FDWJEDYUZLTROC
|
7.7 | IC50 | 2 | Yes | |
FWBIASCKMYRNDJ
|
7.7 | IC50 | 3 | — | |
IEUOUJJNJLUEKA
|
7.7 | IC50 | 3 | — | |
KBSAFYOLMAOOHI
|
7.7 | IC50 | 3 | — | |
KNNAWFQMISAWMQ
|
7.7 | IC50 | 4 | — | |
LHLGUOHREUTYTO
|
7.7 | IC50 | 4 | Yes | |
PJLNANCIFHCOOI
|
7.7 | IC50 | 3 | — | |
QNABDSWBQJKBHK
|
7.7 | IC50 | 45 | — | |
UOOYLPNPSPMGPL
|
7.7 | IC50 | 2 | Yes | |
WRRDYKDAGMFYDS
|
7.7 | IC50 | 3 | — | |
XHHBBSIBRLADLF
|
7.7 | IC50 | 3 | Yes | |
YISJYTBPXCDWRG
|
7.7 | IC50 | 3 | — | |
WSJUWJIMIXGBMP
|
7.7 | IC50 | 3 | — | |
WTAQCNIHHUWNEI
|
7.7 | IC50 | 3 | — | |
ANUHLKPVOXDYSK
|
7.7 | IC50 | 5 | Yes | |
BKTRPBNJGGQIDR
|
7.7 | IC50 | 2 | Yes | |
CQBBMNXXVMOFCA
|
7.7 | Ki | 39 | — | |
DPSNOZFUMXEANO
|
7.7 | Kd | 7 | — | |
FPIOJWKCVYGQDH
|
7.7 | IC50 | 2 | — | |
IIDMUIQJQRELNA
|
7.7 | IC50 | 3 | — | |
KKYYLKPGILUPOA
|
7.7 | IC50 | 2 | — | |
LFWZBKOBTWZOSO
|
7.7 | IC50 | 3 | — | |
LHVUZIHFLUPGOR
|
7.7 | Ki | 3 | — | |
RNHWXYKRVZUXGO
|
7.7 | IC50 | 4 | Yes | |
RZDRBCYADHCOMG
|
7.7 | IC50 | 3 | Yes | |
YGTYIGUWQYTZMS
|
7.7 | IC50 | 5 | Yes | |
CPTZKLNMWGFJMW
|
7.7 | IC50 | 3 | — | |
FJZYDLSIPJYWLO
|
7.7 | IC50 | 3 | — | |
GZYUJXFTHLKPAK
|
7.7 | IC50 | 16 | — | |
HFYHVKQQIOBAEU
|
7.7 | IC50 | 3 | — | |
MRKUZTPMEBRBGD
|
7.7 | IC50 | 6 | Yes | |
PKFMTQRFZPFQOL
|
7.7 | IC50 | 4 | Yes | |
ZCHQPXGYEGSHHI
|
7.7 | IC50 | 3 | — | |
ZDPCJOGRIURSJF
|
7.7 | IC50 | 3 | — |