Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MYSJNRWPLKEUQT
|
7.9 | IC50 | 3 | Yes | |
DJTBULPBPRKGAA
|
7.8 | IC50 | 3 | — | |
HMYOERVFCVBIDK
|
7.8 | IC50 | 2 | — | |
PNGBKTYRDRRBHW
|
7.8 | IC50 | 2 | — | |
SFCBIFOAGRZJNX
|
7.8 | IC50 | 22 | — | |
VCIZTTBXGHPRNG
|
7.8 | IC50 | 3 | — | |
WKGOYAITUGNCTH
|
7.8 | IC50 | 3 | — | |
YHVHYWYQEFELOW
|
7.8 | IC50 | 44 | — | |
GJVXJJBBFWSHCE
|
7.8 | IC50 | 3 | — | |
MIMOHMCANSGXIG
|
7.8 | IC50 | 15 | — | |
OHIWAMBAFXDJCL
|
7.8 | IC50 | 3 | — | |
OYFMIXVMTCYDNY
|
7.8 | IC50 | 6 | Yes | |
OYGDJHWZWUTPMA
|
7.8 | IC50 | 3 | — | |
IEUOUJJNJLUEKA
|
7.8 | IC50 | 3 | — | |
YUHZJDRGEZEUPG
|
7.8 | IC50 | 3 | — | |
YWBVWSHNELZBSY
|
7.8 | IC50 | 3 | — | |
ZGNQSVGROPGZJH
|
7.8 | IC50 | 3 | — | |
BLSPNFYOEQQKRX
|
7.8 | IC50 | 3 | — | |
BXLUWCTUPWMDCS
|
7.8 | IC50 | 3 | — | |
FDVSOQRNTAPCHB
|
7.8 | IC50 | 8 | Yes | |
FDVSOQRNTAPCHB
|
7.8 | IC50 | 7 | Yes | |
NKHIQOIFPZJFIJ
|
7.8 | IC50 | 3 | — | |
OSMXTIVEGNMCKM
|
7.8 | IC50 | 4 | — | |
OSYIMIXLSSLOOL
|
7.8 | IC50 | 3 | Yes | |
PISGPHDAGMGMKC
|
7.8 | IC50 | 3 | — | |
BCNXUFFSRWFFQA
|
7.8 | IC50 | 5 | Yes | |
ILGMYQYCPUUOPG
|
7.8 | IC50 | 3 | — | |
LVUXAWRXYVQYCL
|
7.8 | IC50 | 3 | — | |
NYQWECLBSROSIH
|
7.8 | IC50 | 3 | Yes | |
BKJJVWHHAJLUBN
|
7.8 | IC50 | 3 | — | |
CNTCGRJDUJEUDG
|
7.8 | Ki | 37 | — | |
CXBBWVXSZINRCS
|
7.8 | Ki | 41 | — | |
CXQHYVUVSFXTMY
|
7.8 | Kd | 154 | — | |
DNUVLSNUBQBRGD
|
7.8 | IC50 | 3 | — | |
FRBJLBMEOUWTOH
|
7.8 | IC50 | 3 | — | |
IYQIOGJCUAGVFI
|
7.8 | IC50 | 3 | — | |
VVCDNHTZFHPQAO
|
7.8 | IC50 | 2 | — | |
XHBVYDAKJHETMP
|
7.8 | IC50 | 24 | Yes | |
XZXHXSATPCNXJR
|
7.8 | IC50 | 165 | Yes | |
GBRPACVUTURRQM
|
7.8 | IC50 | 3 | — | |
QQINESIKODNTIF
|
7.8 | IC50 | 3 | — | |
GXSZEJJGRAAVEG
|
7.8 | IC50 | 3 | — | |
UHTHHESEBZOYNR
|
7.8 | Kd | 66 | Yes | |
URRPZVFWMHHCKB
|
7.8 | IC50 | 2 | — | |
YAUXUMSQGNPGQC
|
7.8 | IC50 | 3 | Yes | |
DHCQKGFZVKTVEF
|
7.8 | IC50 | 3 | — | |
DSBDQQZXJGSZOC
|
7.8 | IC50 | 3 | — | |
GKYIMGQLHMZWQQ
|
7.8 | IC50 | 3 | — | |
ITCYMXGHPXIVGP
|
7.8 | IC50 | 3 | — | |
MKGFHPAZLLBPRL
|
7.8 | IC50 | 3 | — |