Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HDDUUZGGSSXLOF
|
8.0 | IC50 | 3 | — | |
ODPGGGTTYSGTGO
|
8.0 | Kd | 153 | — | |
OPHSZSZDICRBPP
|
8.0 | IC50 | 16 | — | |
QHGOOYBPYMDOFS
|
8.0 | IC50 | 4 | Yes | |
YHTSUIXFAAQWLU
|
8.0 | IC50 | 2 | — | |
YSWLNXFQMMFDFG
|
8.0 | IC50 | 2 | — | |
ZCHQPXGYEGSHHI
|
8.0 | IC50 | 3 | — | |
WOUDYEFJPOTAMK
|
8.0 | IC50 | 3 | — | |
BHIWBHXJQRREGM
|
7.9 | IC50 | 4 | Yes | |
BKJJVWHHAJLUBN
|
7.9 | IC50 | 3 | — | |
MWELGVLXXIZJCE
|
7.9 | IC50 | 3 | — | |
UHOKAMTZGAPIKI
|
7.9 | IC50 | 3 | — | |
WRDBAVILVSZTIZ
|
7.9 | IC50 | 3 | — | |
WRDBAVILVSZTIZ
|
7.9 | IC50 | 3 | — | |
WRYUKBQQKYRKQD
|
7.9 | IC50 | 3 | — | |
AEWOIXIGWWYLRF
|
7.9 | IC50 | 3 | — | |
URNMUIDFWOJTPW
|
7.9 | Ki | 7 | Yes | |
CEHFSPNJELKNGN
|
7.9 | IC50 | 3 | — | |
DQHVUKLVCBJBLM
|
7.9 | IC50 | 8 | — | |
HHFKFLKVLVSVDO
|
7.9 | IC50 | 2 | Yes | |
HNVQTCZBDLZQLO
|
7.9 | IC50 | 3 | — | |
JUSWPUDQOKINJO
|
7.9 | IC50 | 16 | — | |
OQCCIANNQMEJOB
|
7.9 | IC50 | 3 | — | |
PPCDZYRDXIKRDW
|
7.9 | IC50 | 6 | Yes | |
QLKGZBYGKCVLEX
|
7.9 | IC50 | 5 | Yes | |
SKDSRJRRAQLUPP
|
7.9 | IC50 | 8 | Yes | |
XIAPVNDAOMFCDE
|
7.9 | IC50 | 2 | Yes | |
ZHUNOLCHKCVGKO
|
7.9 | IC50 | 3 | — | |
ZZNHNGWYLUNNCT
|
7.9 | IC50 | 3 | — | |
FILQIUCXPQZUON
|
7.9 | IC50 | 5 | Yes | |
GBRPACVUTURRQM
|
7.9 | IC50 | 3 | — | |
FYDXVJGBRFZNAN
|
7.9 | IC50 | 3 | — | |
KNARVZUUCLIBGV
|
7.9 | Ki | 33 | — | |
LGZCPROBSNOPBQ
|
7.9 | IC50 | 3 | — | |
NULDFISJLMZSAB
|
7.9 | IC50 | 3 | — | |
RIURYJBLZUYQIW
|
7.9 | IC50 | 3 | — | |
UUWNXFJBBYAMDT
|
7.9 | Ki | 46 | — | |
FUZSHLVNKZZEKR
|
7.9 | IC50 | 16 | — | |
HXLADLNGYXZCMU
|
7.9 | IC50 | 3 | — | |
YJSFAHMGDRBZGH
|
7.9 | IC50 | 16 | Yes | |
GXZDNYIGAGDQLG
|
7.9 | IC50 | 3 | — | |
HXLADLNGYXZCMU
|
7.9 | IC50 | 3 | — | |
INIPJCMUHKXHJQ
|
7.9 | IC50 | 6 | Yes | |
JDFGIOCJMJJUNK
|
7.9 | IC50 | 6 | Yes | |
WHOHIBXOMRSQNS
|
7.9 | IC50 | 3 | — | |
WSJUWJIMIXGBMP
|
7.9 | IC50 | 3 | — | |
WTTUTRXPNFTTPC
|
7.9 | IC50 | 3 | — | |
ZFGRQAXIHZXQBZ
|
7.9 | IC50 | 4 | Yes | |
GXSZEJJGRAAVEG
|
7.9 | IC50 | 3 | — | |
JSVAQNCBNKUVIB
|
7.9 | IC50 | 3 | — |