Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
PEGWVOKOYYAQEV
|
8.1 | IC50 | 9 | — | |
UQNNJYLAPYGZBD
|
8.1 | Ki | 28 | — | |
ZMNIUTKMAXSZLK
|
8.1 | IC50 | 2 | Yes | |
JJEXCYFPMUXZQV
|
8.1 | IC50 | 3 | — | |
KPSDPUDIOPLZOR
|
8.1 | IC50 | 3 | — | |
MHTASDRPMCOWMW
|
8.1 | IC50 | 3 | — | |
QXDWLMJUKFRTHN
|
8.1 | IC50 | 3 | — | |
YISJYTBPXCDWRG
|
8.1 | IC50 | 3 | — | |
AOWZYNWNRVOUEX
|
8.1 | IC50 | 3 | — | |
SHMSECDXWNWTEF
|
8.1 | IC50 | 4 | — | |
KPSDPUDIOPLZOR
|
8.1 | IC50 | 3 | — | |
OBLWMYNSTHSSDS
|
8.1 | IC50 | 6 | Yes | |
WSFBAYOQRJXMIL
|
8.1 | IC50 | 3 | — | |
CJYCKAYGDBEFOV
|
8.1 | IC50 | 3 | — | |
DMZTWOCJNVKCBW
|
8.1 | IC50 | 6 | Yes | |
IHLHILBYSDYCSB
|
8.1 | IC50 | 3 | — | |
WRYUKBQQKYRKQD
|
8.1 | IC50 | 3 | — | |
BLSPNFYOEQQKRX
|
8.0 | IC50 | 3 | — | |
FYSSYSJLLGDXSS
|
8.0 | IC50 | 3 | — | |
GTCCTXMDEHLUPB
|
8.0 | IC50 | 3 | — | |
JSVAQNCBNKUVIB
|
8.0 | IC50 | 3 | — | |
LSAMUOBRDYZNIN
|
8.0 | IC50 | 3 | — | |
MWNASUNUUFWMNK
|
8.0 | IC50 | 4 | — | |
CJYCKAYGDBEFOV
|
8.0 | IC50 | 3 | — | |
GFHVYXFCSPKJGR
|
8.0 | IC50 | 3 | — | |
GOQVUNGLXCWJNX
|
8.0 | IC50 | 3 | — | |
HYNCPFLCZJKDDV
|
8.0 | IC50 | 3 | — | |
SGTWKYSAVBRJTH
|
8.0 | IC50 | 3 | — | |
WYYDKVUNYRLXHX
|
8.0 | IC50 | 4 | Yes | |
BZBBQXMBSCKMNN
|
8.0 | IC50 | 2 | — | |
CFIBXVQLBVNOHW
|
8.0 | Ki | 64 | — | |
GTLYPMCHYLJPTD
|
8.0 | IC50 | 4 | Yes | |
KJUCPVIVNLPLEE
|
8.0 | IC50 | 10 | — | |
NBCNLDUNNGODFI
|
8.0 | IC50 | 2 | Yes | |
NFMGZVPRGVERNN
|
8.0 | Ki | 44 | — | |
SBLMCLDRWJNEJK
|
8.0 | IC50 | 17 | — | |
XJSFDMGICAWQFS
|
8.0 | Ki | 60 | — | |
GOQVUNGLXCWJNX
|
8.0 | IC50 | 3 | — | |
GXZDNYIGAGDQLG
|
8.0 | IC50 | 3 | — | |
WXRUDQFELXWJCU
|
8.0 | IC50 | 3 | — | |
AIKXFQYBAQZYOI
|
8.0 | IC50 | 3 | — | |
OUQCWTKXHVIBQY
|
8.0 | IC50 | 3 | — | |
RIURYJBLZUYQIW
|
8.0 | IC50 | 3 | — | |
VIWNREIXEHEUNK
|
8.0 | IC50 | 3 | — | |
XWEQTIKWMKXSRC
|
8.0 | IC50 | 3 | — | |
CDISOBGWDHAHGF
|
8.0 | IC50 | 16 | — | |
CLLDBMRRUZYRLR
|
8.0 | Ki | 3 | — | |
COGZHOHLOCYJAR
|
8.0 | IC50 | 3 | — | |
DYNFQMKUWXPOPP
|
8.0 | IC50 | 3 | — | |
FACSDOITOHWERB
|
8.0 | IC50 | 2 | — |