Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NGHLDGQMLPKNQH
|
8.2 | IC50 | 3 | — | |
NSOPDMYYXBLFIE
|
8.2 | IC50 | 3 | — | |
OYDJAYPDIUTXRU
|
8.2 | IC50 | 3 | — | |
RKNYQDPVAHZMFZ
|
8.2 | IC50 | 3 | — | |
SEBJMEOEEFXHFF
|
8.2 | IC50 | 2 | Yes | |
SEJGTFPOEJWEGG
|
8.2 | Kd | 149 | — | |
XNSZHQUDPHATEN
|
8.2 | IC50 | 2 | — | |
YSIGPHXBCCDXSF
|
8.2 | IC50 | 3 | — | |
HUWWFMIOBNQUBG
|
8.2 | IC50 | 3 | — | |
UEPKOBLDGLEGJN
|
8.2 | IC50 | 3 | — | |
YJYFCZXVXPEVDA
|
8.2 | IC50 | 2 | — | |
ITCYMXGHPXIVGP
|
8.2 | IC50 | 3 | — | |
JIELCMPAQDQSGM
|
8.2 | IC50 | 3 | — | |
ULHGAQSVFPOUDY
|
8.2 | Ki | 43 | — | |
YJYFCZXVXPEVDA
|
8.2 | IC50 | 2 | — | |
AEWOIXIGWWYLRF
|
8.2 | IC50 | 3 | — | |
HTEUQPWFMDGLKN
|
8.2 | IC50 | 6 | Yes | |
UJEQWHRLDYTMPE
|
8.2 | IC50 | 3 | — | |
ZFHREWWRBHSDLZ
|
8.2 | IC50 | 4 | — | |
OTVZINKZMKEJRF
|
8.2 | IC50 | 3 | — | |
MHTASDRPMCOWMW
|
8.2 | IC50 | 3 | — | |
AAKPXOAXEDWFEB
|
8.2 | IC50 | 2 | — | |
BIPPSOZOQMDQPZ
|
8.2 | IC50 | 4 | — | |
GEATXDJAPAHPTP
|
8.2 | IC50 | 10 | — | |
HLILQABBLFGERM
|
8.2 | IC50 | 6 | Yes | |
HVKVREKLPAMYHA
|
8.2 | IC50 | 2 | Yes | |
LSJWYMSFUWBGPN
|
8.2 | IC50 | 17 | — | |
MDBPVHFMWKYINB
|
8.2 | IC50 | 3 | Yes | |
PDQSBODXIIIHSM
|
8.2 | IC50 | 3 | Yes | |
WQTDKOSNNMUDQK
|
8.2 | IC50 | 5 | — | |
YWDUWTRHFYJSRS
|
8.2 | IC50 | 2 | — | |
ZFVFROXJZKNYAE
|
8.2 | IC50 | 2 | — | |
IHLHILBYSDYCSB
|
8.1 | IC50 | 3 | — | |
OLGFKJJJBLWTNP
|
8.1 | IC50 | 4 | Yes | |
SIDDXBFGWXCHPV
|
8.1 | IC50 | 3 | — | |
XPCRRISAPINSAR
|
8.1 | IC50 | 3 | — | |
YAXIXGGRDHAOJL
|
8.1 | IC50 | 3 | — | |
HUWWFMIOBNQUBG
|
8.1 | IC50 | 3 | — | |
BMHCYYLFLWTPHZ
|
8.1 | IC50 | 4 | Yes | |
GFHVYXFCSPKJGR
|
8.1 | IC50 | 3 | — | |
GPZUXZGXTOGHQQ
|
8.1 | IC50 | 3 | — | |
IOSKHROQBBQEOB
|
8.1 | IC50 | 2 | — | |
KOKLCDIDXBPUBH
|
8.1 | IC50 | 3 | — | |
LRWRLTZIJZAZFD
|
8.1 | IC50 | 3 | — | |
LVSWEGNPHRUXSW
|
8.1 | IC50 | 3 | — | |
MMJHUKOMQZXIPW
|
8.1 | IC50 | 3 | — | |
NPQXBWUMESYMDC
|
8.1 | IC50 | 3 | — | |
ORRHVRJUSPCILV
|
8.1 | Ki | 16 | — | |
OTVCFDOYUHREFJ
|
8.1 | Ki | 26 | — | |
OWFXKTOLFUQPDJ
|
8.1 | Ki | 36 | — |