Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DIVVQJIIRBQSMU
|
6.0 | IC50 | 2 | — | |
FWXNEFMIRVAQLN
|
6.0 | IC50 | 4 | — | |
GBJVVSCPOBPEIT
|
6.0 | Ki | 13 | Yes | |
GLBZSOQDAOLMGC
|
6.0 | IC50 | 23 | Yes | |
HGLWPJISHDLCTE
|
6.0 | IC50 | 7 | — | |
HIMUHMBGRATXMK
|
6.0 | IC50 | 2 | — | |
IAKGNUWZPSPEKU
|
6.0 | Ki | 19 | — | |
INJUVNWOFHYUIN
|
6.0 | Ki | 9 | Yes | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KEZAHTDTAWUZDU
|
6.0 | Ki | 8 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
LFWUGCULXWIAOP
|
6.0 | IC50 | 2 | Yes | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
NECQZMQPXFYVOY
|
6.0 | Ki | 26 | — | |
NERQMDXDVAZVNX
|
6.0 | Ki | 13 | — | |
OMWMITRWODCQFK
|
6.0 | IC50 | 3 | — | |
OZHHLHNBHBGTSP
|
6.0 | IC50 | 3 | Yes | |
PSCJSWRVCKUMSL
|
6.0 | Ki | 35 | — | |
SDBOIBYRBWPIEL
|
6.0 | Ki | 31 | — | |
SEVCBWKJSOLMNQ
|
6.0 | Ki | 38 | — | |
TXHOCWWJSGCZLC
|
6.0 | Ki | 18 | — | |
VCSQVKQFGYRGEH
|
6.0 | Ki | 13 | — | |
VGXCATLWCWFSPS
|
6.0 | IC50 | 3 | Yes | |
VTGUKXAQUOKKSW
|
6.0 | IC50 | 3 | — | |
WUWDLXZGHZSWQZ
|
6.0 | Ki | 41 | — | |
XDUSWBSGDKRQAF
|
6.0 | IC50 | 2 | — | |
YUOWJICKAJQZLS
|
6.0 | Ki | 35 | — | |
ZQQVWTACALNOAJ
|
6.0 | Ki | 11 | — | |
FZLOALBUJDUYTI
|
Clinical | TTD_MultiTarget | 2 | Yes | |
GONCOGHZCWCVGP
|
Clinical | TTD_MultiTarget | 2 | Yes | |
GXKSGTIXGWDSGJ
|
Clinical | TTD_MultiTarget | 12 | Yes | |
HREICXYSTRPUKL
|
Clinical | TTD_MultiTarget | 2 | Yes | |
JHZHLPIBCPQAJX
|
Clinical | TTD_MultiTarget | 2 | Yes | |
UJWXPHLWGVGIBB
|
Clinical | TTD_MultiTarget | 2 | Yes | |
VKCVHBODVYGOIW
|
Clinical | TTD_MultiTarget | 4 | Yes | |
XBTDIGWGOZVBHQ
|
Clinical | TTD_MultiTarget | 2 | Yes | |
ZRJHBFSZDXIBLM
|
Clinical | TTD_MultiTarget | 2 | Yes |