Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YVMCTVCGSKMRCI
|
6.1 | IC50 | 3 | — | |
VNDDOAWIHYNTOI
|
6.1 | IC50 | 3 | — | |
WOKGDWSLHLGJCZ
|
6.1 | IC50 | 3 | Yes | |
MGUOEMOYOJLRIK
|
6.1 | IC50 | 2 | — | |
QXPNJMHRUZCEAP
|
6.1 | IC50 | 14 | — | |
UORAPQCBWYIISR
|
6.1 | IC50 | 15 | — | |
YMSXHRWUGLAAKL
|
6.1 | IC50 | 14 | Yes | |
BFSMGDJOXZAERB
|
6.1 | Kd | 33 | — | |
BLXAELRPPPAZNL
|
6.1 | IC50 | 2 | — | |
GMVQPWCWWLPOQT
|
6.1 | IC50 | 3 | — | |
NNJCLAJJCAILRT
|
6.1 | IC50 | 2 | — | |
AHJRPTVABKSPBA
|
6.1 | IC50 | 3 | — | |
BHSOPYVVEZFHDB
|
6.1 | Ki | 25 | Yes | |
DDQFACKDLYLRGU
|
6.1 | IC50 | 5 | Yes | |
FONINLXADYUZFI
|
6.1 | Ki | 25 | — | |
GXFGHUNNGNQSMQ
|
6.1 | Ki | 19 | — | |
ISVHLTLEHRZKJC
|
6.1 | Ki | 19 | — | |
JNXJKTXDSPWNRP
|
6.1 | Ki | 30 | — | |
LOWUDHVVHHIQKL
|
6.1 | IC50 | 2 | — | |
NCPXFACDZCEIQL
|
6.1 | Ki | 7 | — | |
NMHMCXTYPRADBA
|
6.1 | Ki | 20 | — | |
NYCMTZDIVLFLKV
|
6.1 | IC50 | 3 | — | |
NZVDDFRUBIEKLV
|
6.1 | Ki | 20 | — | |
PCQMERRARZKTPW
|
6.1 | Ki | 68 | — | |
PDBPUXLUVDSLML
|
6.1 | Ki | 14 | — | |
PKCDDUHJAFVJJB
|
6.1 | Ki | 13 | — | |
RDFXBYJUHGEYHA
|
6.1 | IC50 | 9 | Yes | |
UOVCGJXDGOGOCZ
|
6.1 | Ki | 59 | — | |
YJMWLWKXYJRSBL
|
6.1 | IC50 | 2 | — | |
IPFQMFOPNXOZJB
|
6.1 | IC50 | 2 | — | |
UFKINFUUYHPLQS
|
6.1 | IC50 | 3 | — | |
XLFNLJYGUOLEJS
|
6.1 | IC50 | 26 | — | |
HYNCPFLCZJKDDV
|
6.1 | IC50 | 3 | — | |
IPBBLOJPAZIORI
|
6.1 | IC50 | 2 | — | |
JGWRKYUXBBNENE
|
6.1 | IC50 | 11 | — | |
OKFAZZUSWJWRJN
|
6.1 | IC50 | 8 | — | |
PSZVRCRTXCCMNS
|
6.1 | IC50 | 3 | — | |
SPZDCHRXPBSIHM
|
6.1 | IC50 | 6 | — | |
LOLPPWBBNUVNQZ
|
6.0 | Kd | 97 | Yes | |
TYRRNKNTRGLDAB
|
6.0 | Ki | 2 | — | |
QQVWHLARMCUHGI
|
6.0 | IC50 | 2 | — | |
TXIUPNHPXDVAAM
|
6.0 | IC50 | 5 | — | |
VMZBKTOJOWBBSN
|
6.0 | IC50 | 2 | — | |
HJWSKMQXMBSGEX
|
6.0 | IC50 | 2 | — | |
DLMBMHOJKBPKLK
|
6.0 | IC50 | 5 | — | |
PKUNWOUAVLHPIJ
|
6.0 | IC50 | 2 | — | |
JYDWXFPHARBUAB
|
6.0 | IC50 | 2 | — | |
BGLPZSPBYFJHQQ
|
6.0 | IC50 | 2 | — | |
BYYYCNUDMZSOGS
|
6.0 | IC50 | 5 | Yes | |
DCTBPIBEQFLAOQ
|
6.0 | Ki | 13 | — |