Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AIMHAFQTBGSBMF
|
8.4 | IC50 | 3 | Yes | |
FIVXJBFMVDAATB
|
8.4 | IC50 | 3 | — | |
LXBUSRPKZONHPE
|
8.4 | IC50 | 4 | Yes | |
MULNSLQVKKUPJN
|
8.4 | Ki | 41 | — | |
OJGIMVAHBIOHAU
|
8.4 | IC50 | 2 | — | |
OUKYUETWWIPKQR
|
8.4 | IC50 | 31 | Yes | |
PBBRWFOVCUAONR
|
8.4 | IC50 | 26 | Yes | |
SGCUQKJVPGLLDF
|
8.4 | IC50 | 2 | — | |
VKBFHTIUXUCYRQ
|
8.4 | Ki | 66 | — | |
CNEOTFWIHFCFNF
|
8.4 | IC50 | 3 | — | |
OHIWAMBAFXDJCL
|
8.4 | IC50 | 3 | — | |
QFXFIEVXAUEHEV
|
8.4 | Kd | 6 | — | |
ITCYMXGHPXIVGP
|
8.4 | IC50 | 3 | — | |
BAERCKKCRJAXKF
|
8.4 | IC50 | 3 | — | |
KHNQXHOQZWQJSH
|
8.4 | IC50 | 3 | — | |
KXTIIOOGQPWWGE
|
8.3 | IC50 | 6 | Yes | |
LGMDJFPPNVPECO
|
8.3 | IC50 | 3 | Yes | |
ZDPCJOGRIURSJF
|
8.3 | IC50 | 3 | — | |
MAJYBVPWCZGHPD
|
8.3 | IC50 | 3 | — | |
CYXPHNZJEDAZDD
|
8.3 | IC50 | 2 | — | |
FCXFBAVJAPHCTG
|
8.3 | IC50 | 3 | — | |
KSUDUUBCXJUFRL
|
8.3 | Kd | 12 | — | |
OHIWAMBAFXDJCL
|
8.3 | IC50 | 3 | — | |
DWRGCIFPKCMJTG
|
8.3 | IC50 | 3 | — | |
HKSZLNNOFSGOKW
|
8.3 | IC50 | 49 | Yes | |
SUXULCDTOIYHQM
|
8.3 | Kd | 5 | — | |
UEPKOBLDGLEGJN
|
8.3 | IC50 | 3 | — | |
CUMCRGNQXBJWCW
|
8.3 | IC50 | 3 | — | |
KHUHMPCMKSWRNR
|
8.3 | IC50 | 3 | — | |
LFWOSFIIDBDMCH
|
8.3 | IC50 | 3 | — | |
GTCCTXMDEHLUPB
|
8.3 | IC50 | 3 | — | |
NARHSEFAUJNSIV
|
8.3 | IC50 | 3 | — | |
DWRGCIFPKCMJTG
|
8.2 | IC50 | 3 | — | |
FMETVQKSDIOGPX
|
8.2 | IC50 | 7 | Yes | |
NHYQTRZJXXIGIG
|
8.2 | IC50 | 3 | — | |
ZEYDBVDHJVJKOI
|
8.2 | IC50 | 3 | — | |
AFQZLRQRMXCEMZ
|
8.2 | IC50 | 3 | — | |
BPROBXOFSXWRJR
|
8.2 | Kd | 5 | — | |
YQPHBBQBBMIYLO
|
8.2 | IC50 | 6 | Yes | |
AFQZLRQRMXCEMZ
|
8.2 | IC50 | 3 | — | |
MCHPKOULFPNIOZ
|
8.2 | IC50 | 3 | — | |
SRSQULBCTWSVKL
|
8.2 | IC50 | 15 | — | |
VCIZTTBXGHPRNG
|
8.2 | IC50 | 3 | — | |
BKFMJUUGFQKVEV
|
8.2 | IC50 | 3 | — | |
DINVXRZOGZOFRM
|
8.2 | IC50 | 3 | — | |
GQKHMFJDTFXZNM
|
8.2 | IC50 | 5 | Yes | |
HLOUKEPLQBQTTQ
|
8.2 | IC50 | 3 | — | |
IOGHGRWQKSUBIK
|
8.2 | IC50 | 2 | Yes | |
IYUXAJHPXXWFQO
|
8.2 | IC50 | 2 | — | |
JJEXCYFPMUXZQV
|
8.2 | IC50 | 3 | — |