Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZCCPLJOKGAACRT
|
6.2 | Kd | 599 | — | |
ZQADJVAMOQTKDB
|
6.2 | IC50 | 3 | — | |
DZUFTTMDQLYMBE
|
6.2 | IC50 | 10 | Yes | |
ILWOIMOKLTUADE
|
6.2 | IC50 | 4 | — | |
MBHHJCMRPHUOAD
|
6.2 | IC50 | 4 | — | |
SQKBBDOFPPNVCL
|
6.2 | IC50 | 4 | — | |
UFLGKZDFVFEGCP
|
6.2 | IC50 | 6 | Yes | |
VERWOWGGCGHDQE
|
6.2 | IC50 | 23 | — | |
YNUAYENQUDYECY
|
6.2 | IC50 | 3 | — | |
DHDGEXQRDYQYKP
|
6.2 | IC50 | 2 | — | |
DKJPYCPAVXDNLO
|
6.2 | IC50 | 2 | — | |
FAYFPKOZAHXDIT
|
6.2 | IC50 | 2 | — | |
GMYYMEOGFRKSFS
|
6.2 | Ki | 29 | — | |
HCNIBOQWDVOZKF
|
6.2 | Ki | 26 | — | |
HEUSUIRCBWROMH
|
6.2 | Ki | 64 | — | |
HRZOUBQYVUXBNS
|
6.2 | Ki | 38 | — | |
HZPACYSNLOCDLW
|
6.2 | Ki | 48 | — | |
KTQYQHLIMZOBSM
|
6.2 | Ki | 12 | — | |
LYNBNVBMAGDJRW
|
6.2 | Ki | 81 | — | |
OQNPAZRZCXFOBC
|
6.2 | Ki | 11 | — | |
QAKMQVCMEPKBHL
|
6.2 | Ki | 11 | — | |
QPORZABOFXPRHM
|
6.2 | Ki | 18 | — | |
RIUZPIBUSOHUKF
|
6.2 | Ki | 23 | — | |
RMTJSBZCZKCYHB
|
6.2 | IC50 | 13 | — | |
XGALLCVXEZPNRQ
|
6.2 | Kd | 39 | Yes | |
ZHTVWJDQZBBZHV
|
6.2 | Ki | 9 | — | |
FSCGAETYKPUJTF
|
6.2 | IC50 | 3 | — | |
LLHYIISPPGQGTN
|
6.2 | Ki | 2 | — | |
YABJJWZLRMPFSI
|
6.2 | Kd | 34 | — | |
YGBJJONQEBBXHB
|
6.2 | IC50 | 2 | — | |
GGWDCRXLUJHJBX
|
6.2 | IC50 | 2 | — | |
ICYGQSKHMTYUQT
|
6.2 | IC50 | 3 | — | |
TVHDLBOMEGOWNE
|
6.2 | Ki | 2 | — | |
YPLIRWJSGMDWCE
|
6.2 | IC50 | 2 | — | |
BETBNWGUKZUUAX
|
6.2 | IC50 | 21 | — | |
DHSWXTYFLRUXKS
|
6.2 | IC50 | 6 | Yes | |
FTMLQXAVSYTOLC
|
6.2 | IC50 | 2 | — | |
HFLGPAUKVFOIOT
|
6.2 | IC50 | 4 | Yes | |
IGRYEDIMNMEBBU
|
6.2 | IC50 | 9 | — | |
UQIPWVWRJALLFY
|
6.2 | IC50 | 5 | Yes | |
UZPJPJXENPGVRI
|
6.2 | IC50 | 3 | — | |
VJMLVRWRSSMUGF
|
6.2 | IC50 | 6 | Yes | |
OIJOOTMJWCNRQR
|
6.2 | IC50 | 2 | — | |
SKFDSQFYKXYVPS
|
6.2 | IC50 | 9 | Yes | |
WDJUUISIVREQHL
|
6.2 | IC50 | 6 | Yes | |
FRJOVFNLSNXELB
|
6.1 | IC50 | 3 | — | |
RIQJIFBZCJKJLX
|
6.1 | IC50 | 4 | — | |
RQVWDOMMFOUDTO
|
6.1 | IC50 | 2 | — | |
SOYPGPWJQFUHGG
|
6.1 | IC50 | 3 | — | |
TYNGHODBFDMDKR
|
6.1 | IC50 | 3 | — |