Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UBWVFAXLFXHINF
|
6.3 | IC50 | 4 | — | |
UCOFLDBJVAAAFU
|
6.3 | IC50 | 2 | — | |
UDXNFTYLGDGKTL
|
6.3 | IC50 | 2 | — | |
UFUMSQFMKPHFGV
|
6.3 | IC50 | 3 | — | |
UKKRWUIIZPVZDM
|
6.3 | IC50 | 2 | — | |
UPKSQHCXMSPJLN
|
6.3 | IC50 | 3 | — | |
UVELXPTUBUVDHL
|
6.3 | IC50 | 2 | — | |
UXYQVESVIKVEHT
|
6.3 | IC50 | 3 | — | |
UYAIFLOXHBEIGZ
|
6.3 | IC50 | 2 | — | |
UYPQWNIVKFFUII
|
6.3 | IC50 | 3 | — | |
VFJOIITXTDPWHH
|
6.3 | IC50 | 3 | — | |
VIIJKJPJUMTZGU
|
6.3 | IC50 | 2 | — | |
VQCCZYPJUKJUCY
|
6.3 | IC50 | 3 | — | |
VTXUJCDBGFMVIB
|
6.3 | IC50 | 2 | — | |
VYDPOZRBQLVESU
|
6.3 | IC50 | 2 | — | |
VZXKLZIEIOUSHQ
|
6.3 | IC50 | 2 | — | |
WARWBXVCRXCYPF
|
6.3 | IC50 | 3 | — | |
WGHFINLPJZSBPT
|
6.3 | IC50 | 2 | — | |
WHGCLCOZWIDXLS
|
6.3 | IC50 | 2 | — | |
WWFYYEUUXFNAFM
|
6.3 | IC50 | 3 | — | |
XRLDEBHEHHUKSO
|
6.3 | IC50 | 3 | — | |
YJBUGEZJYGLFJL
|
6.3 | IC50 | 2 | — | |
YKFVBFWYDAULCL
|
6.3 | IC50 | 2 | — | |
YQDGGVYOYHQDIX
|
6.3 | IC50 | 2 | — | |
ZVTYOOQKQKVLKZ
|
6.3 | IC50 | 3 | — | |
ZXTBMPGMUNFAIQ
|
6.3 | IC50 | 3 | — | |
DASFSPDIWCMVRW
|
6.2 | IC50 | 21 | — | |
FRGYOMQWHFXVEU
|
6.2 | IC50 | 3 | — | |
NNJCLAJJCAILRT
|
6.2 | IC50 | 2 | — | |
SBNVERXJWAXIID
|
6.2 | IC50 | 2 | Yes | |
HXEBFWWXKFPHNV
|
6.2 | IC50 | 2 | — | |
IMRNKQWAMWWEKR
|
6.2 | IC50 | 5 | — | |
QQUVFOWMNHSIRI
|
6.2 | IC50 | 2 | — | |
UGOPZRICVJBSEN
|
6.2 | IC50 | 3 | Yes | |
ULXXDDBFHOBEHA
|
6.2 | Kd | 15 | Yes | |
YNVQXAFBFLYMLM
|
6.2 | IC50 | 3 | Yes | |
YPXWUKLQAUBCPF
|
6.2 | IC50 | 8 | — | |
ZJVPEIBBMXWONH
|
6.2 | IC50 | 3 | — | |
HHFBDROWDBDFBR
|
6.2 | Kd | 40 | Yes | |
RVIMFNLCTIXVKN
|
6.2 | IC50 | 4 | — | |
YLQMVIRZBOJBCV
|
6.2 | IC50 | 7 | Yes | |
BOAYLRGFQZSCQR
|
6.2 | IC50 | 2 | — | |
CFIIVSLTMJHIQA
|
6.2 | IC50 | 3 | Yes | |
FVHDMSVWNIOSFF
|
6.2 | IC50 | 2 | — | |
JNAHXDJEKAMVMC
|
6.2 | IC50 | 3 | — | |
KWTDVQYZRZTJDG
|
6.2 | Ki | 2 | — | |
SZJIXBKHTOPEKG
|
6.2 | IC50 | 6 | Yes | |
WJAKMUHDSIHSPY
|
6.2 | IC50 | 6 | Yes | |
XNWKUKZPGCHWNL
|
6.2 | IC50 | 2 | — | |
YXHJHTILTPQTEF
|
6.2 | Ki | 2 | — |