Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UQDLRCLRFNHSAU
|
6.3 | IC50 | 2 | — | |
ZMDAIGKVAJVTEG
|
6.3 | IC50 | 2 | — | |
IXHHBCLGJOFBRU
|
6.3 | IC50 | 2 | — | |
JNRFIKALOWSUBG
|
6.3 | Ki | 2 | — | |
UJLAWZDWDVHWOW
|
6.3 | Kd | 16 | — | |
ZZSBPGIGIUFJRA
|
6.3 | Kd | 46 | — | |
FTFDOZLQPLTYBX
|
6.3 | IC50 | 7 | Yes | |
JVAFTPDILUBIGR
|
6.3 | IC50 | 7 | — | |
JVAFTPDILUBIGR
|
6.3 | IC50 | 9 | Yes | |
OLUKILHGKRVDCT
|
6.3 | Ki | 44 | Yes | |
QQUXFYAWXPMDOE
|
6.3 | IC50 | 31 | — | |
SKNUELOYQKBUOU
|
6.3 | IC50 | 2 | — | |
VIXCHKGYFCCMEH
|
6.3 | IC50 | 2 | — | |
XZVCLGAJVSWPFQ
|
6.3 | IC50 | 2 | — | |
FRQGIFZNGIECRT
|
6.3 | IC50 | 2 | — | |
PPISEWGPTNCYKY
|
6.3 | IC50 | 3 | Yes | |
QODQEZHGGGAGFQ
|
6.3 | IC50 | 2 | — | |
SGTWKYSAVBRJTH
|
6.3 | IC50 | 2 | — | |
CMOPUHDFFUAOMA
|
6.3 | Ki | 11 | Yes | |
GKFLWUHMWHBAHM
|
6.3 | IC50 | 2 | — | |
KCEWOOVCWCPFCY
|
6.3 | IC50 | 5 | — | |
LMMPYMLTMDFZRW
|
6.3 | IC50 | 2 | — | |
OOLMBUKZNOBEOR
|
6.3 | IC50 | 3 | — | |
UNJMDMUQCPCLFE
|
6.3 | IC50 | 2 | — | |
ZTQCJUDBNICJBQ
|
6.3 | IC50 | 2 | — | |
AARZYPZTMIRNPN
|
6.3 | Ki | 3 | — | |
CUIHSIWYWATEQL
|
6.3 | Ki | 61 | Yes | |
DJLORVJVWIBDME
|
6.3 | Ki | 24 | — | |
DSBPVMDUESDKNK
|
6.3 | IC50 | 9 | Yes | |
FGSVLADZCDNNOC
|
6.3 | Ki | 11 | — | |
GQGMUKOYILWOIQ
|
6.3 | Ki | 25 | — | |
HAYYBYPASCDWEQ
|
6.3 | Ki | 47 | — | |
JCJSAFZMXVQVBR
|
6.3 | IC50 | 11 | Yes | |
KRHBKGFRNLMKSL
|
6.3 | IC50 | 5 | Yes | |
KRHBKGFRNLMKSL
|
6.3 | IC50 | 3 | — | |
MZDKLVOWGIOKTN
|
6.3 | Ki | 80 | — | |
PUWQBZYOEYJCIO
|
6.3 | IC50 | 6 | Yes | |
QDOBTYVGPGFRCM
|
6.3 | Ki | 11 | — | |
QTVUFFYQYZKGFQ
|
6.3 | IC50 | 3 | Yes | |
RNCVPFCGSMNPPO
|
6.3 | IC50 | 5 | Yes | |
SYVFMRBHXSGATD
|
6.3 | Ki | 2 | — | |
UWDBNTXEKYRMSG
|
6.3 | Ki | 26 | — | |
VUHZDNOPEVGHEO
|
6.3 | Ki | 29 | — | |
WBODIWMNQZMUKS
|
6.3 | Ki | 2 | — | |
WKMYUHUMKWPSCQ
|
6.3 | Ki | 3 | — | |
YEPNVBNYCRGZRX
|
6.3 | Ki | 26 | — | |
YMIJUBCSOKSFRU
|
6.3 | Ki | 87 | — | |
ZVWRFVCNQOECJS
|
6.3 | Ki | 71 | — | |
AILRADAXUVEEIR
|
6.3 | IC50 | 75 | — | |
CSGQVNMSRKWUSH
|
6.3 | Kd | 21 | — |