Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
TTWHYLBRQRYBLK
|
6.4 | IC50 | 2 | — | |
CNYOFMNBFMTOHX
|
6.4 | IC50 | 5 | — | |
OZYSZPHJVXITET
|
6.4 | IC50 | 2 | — | |
QSIAXFKUFXOHHK
|
6.4 | IC50 | 5 | Yes | |
VLNGPEMYJFURLB
|
6.4 | IC50 | 2 | — | |
WWENZKQHNDQUOA
|
6.4 | IC50 | 2 | — | |
ZEYDBVDHJVJKOI
|
6.4 | IC50 | 2 | — | |
BSFNGHCTZDCQBF
|
6.4 | Ki | 93 | — | |
DBXGGXLBTWZXBB
|
6.4 | Ki | 39 | — | |
DFMFALRCABNVBW
|
6.4 | IC50 | 3 | — | |
DJOJKIGNNDWGRS
|
6.4 | Ki | 13 | — | |
GCBJDOWIQHMCMR
|
6.4 | Ki | 84 | — | |
GDYZFFBMSBDTAA
|
6.4 | Ki | 60 | — | |
HQPNLIKXAPLWBQ
|
6.4 | Ki | 12 | Yes | |
HUZDGCVNDDSQGA
|
6.4 | IC50 | 6 | Yes | |
JILSITSMAZDOPL
|
6.4 | IC50 | 3 | — | |
KXPWWMPXNUOYOH
|
6.4 | Ki | 24 | — | |
LBVKEEFIPBQIMD
|
6.4 | Ki | 27 | — | |
NXNQLECPAXXYTR
|
6.4 | Ki | 29 | — | |
OYUDNKFIGXAIRZ
|
6.4 | Ki | 16 | Yes | |
RWEHAHIEUDLKGT
|
6.4 | Ki | 33 | — | |
USKFMBYPIMKTAD
|
6.4 | IC50 | 6 | Yes | |
VWACUNWBMWWMPJ
|
6.4 | Ki | 18 | — | |
WMOZCZVWHZOVFI
|
6.4 | IC50 | 2 | — | |
WQJZGUODVAPUKD
|
6.4 | IC50 | 2 | — | |
WWSWQMMEPXHAON
|
6.4 | IC50 | 6 | Yes | |
ZKHDDJKHTPLPOQ
|
6.4 | Ki | 62 | — | |
DETGKAHYPYOYLU
|
6.4 | IC50 | 2 | — | |
DNUVLSNUBQBRGD
|
6.4 | IC50 | 2 | — | |
FKGIWCGGBHLFPS
|
6.4 | IC50 | 2 | — | |
HFBUYDAMOBVPRQ
|
6.4 | IC50 | 3 | Yes | |
HPTVFAXXEWQCOC
|
6.4 | IC50 | 2 | — | |
JXKDTYDBDDKIPY
|
6.4 | IC50 | 5 | Yes | |
LARWIZLZQUNUQG
|
6.4 | IC50 | 4 | — | |
MXBRHEFPFHSZLC
|
6.4 | IC50 | 3 | — | |
OZYSZPHJVXITET
|
6.4 | IC50 | 2 | — | |
RZYAXQPODGDVBT
|
6.4 | IC50 | 2 | — | |
HLOUKEPLQBQTTQ
|
6.4 | IC50 | 2 | — | |
PTHVKCSYXICMAR
|
6.4 | IC50 | 14 | — | |
QCJFYACTZIVZBB
|
6.4 | IC50 | 8 | — | |
UXHHASKNWWRBLI
|
6.4 | IC50 | 3 | — | |
WJOMVKXZFSMUMB
|
6.4 | IC50 | 3 | — | |
XNWKUKZPGCHWNL
|
6.4 | IC50 | 2 | — | |
SKDBXDGKLQALIZ
|
6.4 | IC50 | 15 | — | |
UIARLYUEJFELEN
|
6.4 | Kd | 289 | Yes | |
WMXDIPVFXWNELM
|
6.4 | IC50 | 14 | Yes | |
ZAAKPRKYIFTIIV
|
6.4 | IC50 | 3 | — | |
HEPDAJRNJBNJAE
|
6.4 | IC50 | 15 | Yes | |
OSETUFDXSRDZOI
|
6.4 | IC50 | 2 | — | |
PGABPPHMLFSKKA
|
6.4 | Ki | 2 | — |