Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
PUPCRRRSBUYJAD
|
6.5 | Ki | 44 | Yes | |
RGNHKJWHFIPHIM
|
6.5 | Ki | 66 | — | |
VSVWQTDDGQSGHP
|
6.5 | Ki | 51 | — | |
WHKWRDQKKUPBMN
|
6.5 | Ki | 7 | — | |
WZZXMNBOPNKKSX
|
6.5 | Ki | 10 | — | |
XLFYOIVELARSKP
|
6.5 | Ki | 33 | — | |
ZLHFILGSQDJULK
|
6.5 | IC50 | 37 | Yes | |
CDXAKGFOHNPQOB
|
6.5 | IC50 | 3 | — | |
LMZWLWNPSGVPBB
|
6.5 | IC50 | 3 | — | |
LYIQUCVGSYXGDF
|
6.5 | IC50 | 2 | — | |
OMZCMEYTWSXEPZ
|
6.5 | Kd | 43 | Yes | |
CPHGZDSYMREPNQ
|
6.5 | IC50 | 6 | — | |
CRLVGIJHOWRLRU
|
6.5 | IC50 | 2 | — | |
HCVSOJQZDUYODJ
|
6.5 | IC50 | 2 | — | |
IBOUTLNFGGJROR
|
6.5 | IC50 | 2 | — | |
IFQNAVPQPNACSS
|
6.5 | IC50 | 3 | — | |
NARHSEFAUJNSIV
|
6.5 | IC50 | 3 | — | |
PZEREPZOAADTTK
|
6.5 | IC50 | 2 | — | |
QKKIWEILHCXECO
|
6.5 | IC50 | 24 | — | |
VQFPMVKAMVDQNA
|
6.5 | IC50 | 2 | — | |
ZATGFXTWDKIEKC
|
6.5 | IC50 | 8 | Yes | |
FWVUUGWQEZWWHV
|
6.5 | IC50 | 6 | Yes | |
JJMCEWIEMJDKKW
|
6.5 | IC50 | 3 | — | |
MHTFQIBQBHDDQE
|
6.5 | IC50 | 2 | — | |
PBQIIKOVMRFZEQ
|
6.5 | IC50 | 3 | Yes | |
QAJMXNDGDLWDAN
|
6.5 | IC50 | 3 | — | |
XFYUTGIEFKGWND
|
6.5 | Ki | 3 | — | |
ZWVZORIKUNOTCS
|
6.5 | IC50 | 10 | Yes | |
HYNCPFLCZJKDDV
|
6.5 | IC50 | 3 | — | |
VYPGLYMWNDRFGZ
|
6.5 | Kd | 12 | — | |
DBHCVYPQRZQCEG
|
6.5 | IC50 | 2 | — | |
MPFMLTBUDZGFRW
|
6.5 | IC50 | 2 | — | |
MDTVHFCFGLWPLA
|
6.4 | IC50 | 2 | — | |
NHYQTRZJXXIGIG
|
6.4 | IC50 | 2 | — | |
OQBJXGADOAMRSR
|
6.4 | IC50 | 5 | — | |
PMZVFSAGPDDIJA
|
6.4 | IC50 | 3 | — | |
RAHBGWKEPAQNFF
|
6.4 | Kd | 26 | — | |
SOWYAXXZAHUERN
|
6.4 | IC50 | 2 | — | |
WJSCDYSIDGEWEB
|
6.4 | IC50 | 5 | Yes | |
CGRLNCABNBKKKW
|
6.4 | IC50 | 4 | — | |
FQFRYNVWFJCZOA
|
6.4 | IC50 | 2 | — | |
LGOFNTKAZMUZQC
|
6.4 | IC50 | 3 | — | |
OBXXVELGHXKSST
|
6.4 | IC50 | 3 | — | |
SEJLPXCPMNSRAM
|
6.4 | IC50 | 7 | — | |
FFNIWOOLZGAOAB
|
6.4 | IC50 | 8 | Yes | |
JZVXAFREQFUEDW
|
6.4 | IC50 | 2 | — | |
PFTXFNSHFZLJNT
|
6.4 | IC50 | 17 | — | |
QGJDHDIEZQDSIA
|
6.4 | IC50 | 2 | — | |
QYZOGCMHVIGURT
|
6.4 | Kd | 26 | Yes | |
SGRYPBLWIZFTHU
|
6.4 | IC50 | 2 | Yes |