Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YMHSMYQKKBITTG
|
6.6 | IC50 | 3 | — | |
YNVOMSDITJMNET
|
6.6 | Kd | 2 | — | |
KHUHMPCMKSWRNR
|
6.6 | IC50 | 2 | — | |
NNQHKTWARZSGTQ
|
6.6 | IC50 | 7 | — | |
PBHYAPKEUOBQSL
|
6.6 | IC50 | 3 | — | |
PQOZSBAPVRIRPG
|
6.6 | IC50 | 3 | — | |
SBSYQSASKXLENU
|
6.6 | IC50 | 5 | Yes | |
FESPQUDYDLXPOA
|
6.6 | IC50 | 2 | — | |
RFUAALIUPJPJCJ
|
6.6 | IC50 | 2 | — | |
YXYHBHJWEGGSMU
|
6.6 | IC50 | 3 | Yes | |
BMGQWWVMWDBQGC
|
6.5 | Kd | 147 | Yes | |
BMGQWWVMWDBQGC
|
6.5 | Kd | 91 | Yes | |
KKUNUMXHGLIOMX
|
6.5 | IC50 | 3 | — | |
OONFVLYMZFAOSH
|
6.5 | IC50 | 2 | — | |
UJEQWHRLDYTMPE
|
6.5 | IC50 | 2 | — | |
ZCIUSITUWMIQKV
|
6.5 | IC50 | 2 | — | |
GGIPEVUWPMVPNG
|
6.5 | IC50 | 5 | Yes | |
HKBVCGJVIFGBEX
|
6.5 | IC50 | 6 | Yes | |
NCRZBWYKAOJRIJ
|
6.5 | IC50 | 2 | — | |
OBSFXHDOLBYWRJ
|
6.5 | IC50 | 7 | Yes | |
XCMUCRMMVDSVEL
|
6.5 | Kd | 2 | — | |
YJQMSQUEWGKXSC
|
6.5 | IC50 | 2 | — | |
AHEHCOROUMSVIO
|
6.5 | IC50 | 3 | — | |
CNEOTFWIHFCFNF
|
6.5 | IC50 | 3 | — | |
XDGHTBHPIPZHLJ
|
6.5 | IC50 | 2 | — | |
ZGBAJMQHJDFTQJ
|
6.5 | Kd | 15 | — | |
DCGOHGQJHJXBGW
|
6.5 | IC50 | 4 | — | |
DMECWJSRBVZTGX
|
6.5 | IC50 | 2 | — | |
FNVQWFPDIYQCSF
|
6.5 | IC50 | 8 | Yes | |
FYNQXKHYYDAGJQ
|
6.5 | IC50 | 2 | — | |
HBDSHCUSXQATPO
|
6.5 | IC50 | 14 | Yes | |
HOQNHSNBIIJJBO
|
6.5 | Ki | 7 | — | |
OOQJIJYKWXLQNC
|
6.5 | IC50 | 16 | Yes | |
OROLCINTIPDVAI
|
6.5 | IC50 | 2 | — | |
SKMKVAWCYDFONZ
|
6.5 | IC50 | 5 | Yes | |
TXGKRVFSSHPBAJ
|
6.5 | IC50 | 11 | — | |
TXSZGBMOPCXBTP
|
6.5 | IC50 | 7 | Yes | |
YJIOYEIAXJVPKR
|
6.5 | IC50 | 2 | — | |
QFGLDTYKBHQKAW
|
6.5 | IC50 | 2 | Yes | |
VPJYHGDUYQHMII
|
6.5 | IC50 | 2 | — | |
XSLOCCCIKXFJLR
|
6.5 | IC50 | 2 | — | |
CLAFAHXMXSENJP
|
6.5 | Ki | 3 | — | |
FOONBYIHFUMRSX
|
6.5 | Ki | 12 | — | |
GSXRCPJTNIGKSZ
|
6.5 | Ki | 43 | — | |
HACQCZAUTIOAKZ
|
6.5 | IC50 | 2 | — | |
HRJWTAWVFDCTGO
|
6.5 | Ki | 13 | Yes | |
KOKLCDIDXBPUBH
|
6.5 | IC50 | 2 | — | |
KROLCVQARUUHNV
|
6.5 | Ki | 12 | — | |
NRZYTPAJGVTKIM
|
6.5 | Ki | 38 | — | |
OYONTEXKYJZFHA
|
6.5 | Kd | 69 | Yes |