Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XOOAAYRIVATZNM
|
9.0 | Ki | 55 | — | |
YOVKYZJMWCAPJA
|
9.0 | IC50 | 3 | Yes | |
HNWZKSBXLQWJOE
|
9.0 | IC50 | 3 | — | |
VAARYSWULJUGST
|
9.0 | Kd | 119 | Yes | |
IFPPYSWJNWHOLQ
|
8.9 | Ki | 52 | Yes | |
VCFDMLBPASGZTP
|
8.9 | Ki | 38 | — | |
JTWMOWRMSZZHDR
|
8.9 | IC50 | 13 | — | |
UBPYILGKFZZVDX
|
8.9 | Kd | 130 | Yes | |
TVNZRDDQMBWCDE
|
8.8 | IC50 | 3 | — | |
MWNASUNUUFWMNK
|
8.8 | IC50 | 3 | — | |
BRTHUECZMVKNMQ
|
8.8 | Ki | 31 | — | |
MHCPAORAYMTGCZ
|
8.8 | Ki | 37 | — | |
UOOZSMNSBYVUGZ
|
8.8 | Ki | 32 | — | |
ZCCJKVBTHCOISJ
|
8.8 | Ki | 46 | — | |
AQSSMEORRLJZLU
|
8.7 | Kd | 34 | Yes | |
DKNUPRMJNUQNHR
|
8.7 | Kd | 33 | — | |
KQWCGDXCRBTZJV
|
8.7 | IC50 | 4 | — | |
LCYSSHSIKSARGO
|
8.7 | IC50 | 19 | — | |
OJMWPSHLUJUPDD
|
8.7 | IC50 | 4 | — | |
TYCSETQHBQUZAZ
|
8.7 | IC50 | 3 | — | |
XCEDFZFYFQZOMX
|
8.7 | IC50 | 3 | Yes | |
XYFPWWZEPKGCCK
|
8.7 | IC50 | 34 | — | |
KEOXYNOFRLIAAM
|
8.7 | IC50 | 3 | — | |
YISMQBFJYDFMAL
|
8.7 | IC50 | 46 | — | |
NKKNQMFHKZEGQU
|
8.6 | IC50 | 5 | — | |
DINVXRZOGZOFRM
|
8.6 | IC50 | 3 | — | |
DINVXRZOGZOFRM
|
8.6 | IC50 | 3 | — | |
UBDKHMQBZNCDSH
|
8.6 | IC50 | 3 | — | |
BIKYDWLMTPRSQL
|
8.6 | Ki | 50 | — | |
SBWCIJOOABLPME
|
8.6 | Ki | 13 | — | |
SRUYMJRFVGLQDV
|
8.6 | Ki | 37 | — | |
KAKJQMPMDALLHT
|
8.6 | IC50 | 3 | — | |
HKSZLNNOFSGOKW
|
8.6 | IC50 | 408 | — | |
DEPQMFLVQJEMPL
|
8.5 | IC50 | 4 | — | |
HQMQBWSLPHAVOU
|
8.5 | IC50 | 4 | — | |
OAILDJYOGMMAOQ
|
8.5 | IC50 | 3 | — | |
UKFKDADMCDDXJG
|
8.5 | IC50 | 2 | — | |
WPHKIQPVPYJNAX
|
8.5 | IC50 | 81 | — | |
WSBZFFNSBMBYQA
|
8.5 | IC50 | 9 | — | |
XHORJSJFHVABEA
|
8.5 | Ki | 49 | — | |
XLYVQVWMTOLDNL
|
8.5 | IC50 | 21 | — | |
XLYVQVWMTOLDNL
|
8.5 | IC50 | 21 | — | |
JWDUTOYRMYEYFY
|
8.5 | IC50 | 2 | — | |
HTUPONJUVMCVCW
|
8.5 | IC50 | 6 | Yes | |
PUNYTBZWCMNSRO
|
8.5 | IC50 | 2 | — | |
LRJOPQDEHYLGQF
|
8.4 | IC50 | 3 | — | |
MCHPKOULFPNIOZ
|
8.4 | IC50 | 2 | — | |
JSFCZQSJQXFJDS
|
8.4 | IC50 | 4 | — | |
LYADGAGFYYXXIO
|
8.4 | IC50 | 82 | — | |
ADLPKFFMGIJZIM
|
8.4 | Ki | 44 | — |