Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OZSBSFCEPXAPAC
|
6.8 | IC50 | 3 | Yes | |
RKFUKWHBZZWJNX
|
6.8 | IC50 | 4 | Yes | |
TVJRDCQUZMGBAB
|
6.8 | IC50 | 13 | — | |
USVGUZMPKPIFFV
|
6.8 | Ki | 2 | — | |
ZLUFMEFGLIZOAP
|
6.8 | IC50 | 3 | — | |
DHHJVKCNCRIXRE
|
6.8 | IC50 | 4 | — | |
ZMHVJFIIASNLTM
|
6.8 | IC50 | 3 | Yes | |
ATFYKJXJVMDYAJ
|
6.8 | IC50 | 3 | — | |
DBXOMQJZSQLQED
|
6.8 | Ki | 12 | — | |
DZSUJUOJJJCWGG
|
6.8 | Ki | 55 | Yes | |
JSDGKSMNPHJDFK
|
6.8 | Ki | 35 | — | |
NFKMFNBKEOQNPZ
|
6.8 | Ki | 43 | — | |
NKEUPUJTVALZIK
|
6.8 | Ki | 28 | — | |
NRGYZNJPCGRCLV
|
6.8 | Ki | 52 | — | |
NVRXTLZYXZNATH
|
6.8 | Ki | 47 | Yes | |
NWAUBAGBGOPJLF
|
6.8 | Ki | 51 | Yes | |
QKPLUKMJEKRAJD
|
6.8 | Ki | 30 | Yes | |
QRDCOOSKIFYKIQ
|
6.8 | Kd | 8 | — | |
QXRJBJVCBQSLTA
|
6.8 | Ki | 29 | — | |
RFOHHTZHDHDNPM
|
6.8 | IC50 | 3 | — | |
RPDVCUCXMGWTFA
|
6.8 | Ki | 10 | — | |
RVACCDUTYQCJFZ
|
6.8 | IC50 | 3 | — | |
SFPWNTQWFFNJIH
|
6.8 | Ki | 48 | — | |
WDZMQMMLPZNCPU
|
6.8 | IC50 | 3 | — | |
PVCKRSKEOOWVMP
|
6.8 | IC50 | 4 | — | |
ZRSYYBBNXPNVSH
|
6.8 | Ki | 3 | — | |
ALKJNCZNEOTEMP
|
6.8 | Kd | 55 | — | |
PETBYXJWYAAALJ
|
6.8 | IC50 | 3 | — | |
QXDWLMJUKFRTHN
|
6.8 | IC50 | 3 | — | |
REZFVUNAFUHYBW
|
6.8 | IC50 | 5 | Yes | |
SZFYZDIPRMLBDC
|
6.8 | IC50 | 9 | — | |
GXEGTVQATHKFDH
|
6.8 | IC50 | 10 | Yes | |
HDNBYWUROCXFTK
|
6.8 | IC50 | 2 | Yes | |
KOLMPPLMZOKCEL
|
6.8 | IC50 | 3 | — | |
QKKHXTGUTLRIAS
|
6.8 | IC50 | 4 | — | |
UHJMMAFUNGKSLA
|
6.8 | IC50 | 2 | — | |
UJEQWHRLDYTMPE
|
6.8 | IC50 | 2 | — | |
KHDZTOGFCVNLOZ
|
6.8 | IC50 | 2 | — | |
CJWIBINTCNTMJT
|
6.8 | IC50 | 4 | — | |
XZNZEFPMAMWWAG
|
6.8 | IC50 | 3 | — | |
IUGBGEUCXVKGQK
|
6.7 | Kd | 13 | — | |
JMJSTGZRLYHCCI
|
6.7 | IC50 | 5 | — | |
JWRJKYQRVMOTSG
|
6.7 | IC50 | 2 | — | |
MEQKJTZVPMNRIL
|
6.7 | IC50 | 2 | — | |
MJTXQVLFZPHAOU
|
6.7 | IC50 | 2 | — | |
QIFSEJGXRCJOGK
|
6.7 | IC50 | 3 | — | |
SVOVJJIXKQRGRV
|
6.7 | IC50 | 2 | — | |
WMMNTQFZCHUZSM
|
6.7 | IC50 | 14 | — | |
ZJSYBNVFNSNIMP
|
6.7 | IC50 | 2 | — | |
GLYDCPPHXDVIKA
|
6.7 | IC50 | 5 | Yes |