Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QYBXDVKBBXOQPH
|
6.9 | IC50 | 3 | — | |
XNFHHOXCDUAYSR
|
6.9 | IC50 | 5 | — | |
DLPARMNJOHFOLU
|
6.9 | Ki | 14 | Yes | |
GCYXEGSPUDSZJY
|
6.9 | Ki | 82 | — | |
GDOTWXUDXHZXHG
|
6.9 | Ki | 3 | — | |
GUBJNPWVIUFSTR
|
6.9 | IC50 | 103 | — | |
HPTVFAXXEWQCOC
|
6.9 | IC50 | 3 | — | |
IKJUHEILBKWLHF
|
6.9 | IC50 | 3 | — | |
MQRDVGBWWVWMEN
|
6.9 | Ki | 47 | — | |
MTCHQDWUHQADSY
|
6.9 | Ki | 29 | — | |
MVJMMLFMPWITEJ
|
6.9 | Ki | 110 | — | |
PTVPBWWDGZSEAF
|
6.9 | Ki | 63 | — | |
RYAVJHIPOWNWDE
|
6.9 | Ki | 38 | — | |
VSPFURGQAYMVAN
|
6.9 | Ki | 17 | — | |
XYXLUJQBBIBJFV
|
6.9 | Ki | 36 | — | |
YDOPLCNFRXOHCC
|
6.9 | Ki | 28 | — | |
AFGOFEFLRMONQO
|
6.9 | IC50 | 2 | Yes | |
GMVQPWCWWLPOQT
|
6.9 | IC50 | 9 | Yes | |
JIBBGYSUSKAPDY
|
6.9 | IC50 | 19 | — | |
OEFUMBDQRIIGBZ
|
6.9 | IC50 | 3 | — | |
RFCPQXPQIFCVHE
|
6.9 | IC50 | 3 | — | |
VXJXHNMYRAHBBO
|
6.9 | IC50 | 5 | — | |
XSWLSCPOLAJGJH
|
6.9 | IC50 | 2 | — | |
JVMXFXGOSURYQL
|
6.9 | IC50 | 3 | — | |
RDTDWGQDFJPTPD
|
6.9 | IC50 | 6 | Yes | |
RFYOGEYTLSCWFY
|
6.9 | IC50 | 3 | — | |
VIHXUAKPZPXVSW
|
6.9 | IC50 | 6 | Yes | |
WLXHZMYOVDOALX
|
6.9 | IC50 | 5 | Yes | |
WTELJZVTIRTWRA
|
6.9 | IC50 | 2 | Yes | |
XNSWVOGEJVAEKL
|
6.9 | IC50 | 3 | — | |
HPTVFAXXEWQCOC
|
6.9 | IC50 | 3 | — | |
IHWDTUMEQRTNBN
|
6.9 | Ki | 2 | — | |
ONQZVCBYRFYYFU
|
6.9 | IC50 | 3 | — | |
SHCJFEFQZWRVRD
|
6.9 | IC50 | 2 | — | |
XSHWQHBWWZLBIM
|
6.9 | IC50 | 3 | — | |
ZJLXSIPWULUCRJ
|
6.9 | Ki | 5 | — | |
GPVOGAITWLZNLK
|
6.8 | IC50 | 2 | — | |
LVMAULGVWBINFP
|
6.8 | IC50 | 6 | — | |
OCTFEANBRUHNTO
|
6.8 | IC50 | 2 | — | |
OFUBWOTWQPAEDG
|
6.8 | IC50 | 6 | — | |
OWDYYQABYMVBBC
|
6.8 | IC50 | 2 | Yes | |
VWELCPLMPPEKOL
|
6.8 | IC50 | 9 | Yes | |
GHRNBCMJJKMYNR
|
6.8 | IC50 | 4 | Yes | |
KBHJOYQXMRWUFC
|
6.8 | IC50 | 3 | — | |
QXTPBRKTCUTGBZ
|
6.8 | IC50 | 2 | — | |
TWWKXZDIDHDHRF
|
6.8 | IC50 | 7 | — | |
ZMNWFTYYYCSSTF
|
6.8 | IC50 | 18 | — | |
APHYPLAMZNZIQK
|
6.8 | IC50 | 3 | — | |
BAQZVMZHRWELTR
|
6.8 | IC50 | 3 | — | |
HQVKWOAGEPGZAS
|
6.8 | IC50 | 3 | Yes |