Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
LGHBDVLAHHANMX
|
7.0 | Ki | 53 | — | |
LNKYOCYVSXPLAH
|
7.0 | IC50 | 3 | — | |
LRLDYTTWQIFWBD
|
7.0 | Ki | 25 | — | |
MFMXAWQGPQXDRJ
|
7.0 | Ki | 27 | — | |
NSKFXNDKPCVDIN
|
7.0 | Ki | 12 | — | |
PROLIXHVRCJEFH
|
7.0 | Ki | 46 | — | |
QDABCLMXECRBLW
|
7.0 | Kd | 2 | — | |
VHWZYWCQBINXOX
|
7.0 | Ki | 3 | — | |
VJHWNDGPWFUUKL
|
7.0 | IC50 | 6 | Yes | |
WDTHDWKPTWWHLS
|
7.0 | IC50 | 13 | — | |
WVUNYSQLFKLYNI
|
7.0 | Kd | 46 | Yes | |
ZDNURMVOKAERHZ
|
7.0 | IC50 | 7 | Yes | |
ZWVZORIKUNOTCS
|
7.0 | Ki | 69 | — | |
ZTSQSKNFQOTFNW
|
7.0 | IC50 | 2 | — | |
PMARLWUYKMTAJS
|
7.0 | IC50 | 3 | — | |
SOLCZUBPADGMSF
|
7.0 | IC50 | 5 | Yes | |
WKDACQVEJIVHMZ
|
7.0 | Kd | 46 | — | |
ISPQNYIDKVVKFT
|
7.0 | IC50 | 2 | — | |
IVKWJLVMIVBKDX
|
7.0 | IC50 | 2 | — | |
UMBDWDIRLTVPBF
|
7.0 | IC50 | 9 | — | |
AKDCUCWSQMYOMD
|
7.0 | Ki | 2 | — | |
DDJRBTANSYPPCR
|
7.0 | IC50 | 3 | Yes | |
GZYCQQBRSRIFII
|
7.0 | Kd | 7 | — | |
LLEOOSLUHRQCHZ
|
7.0 | IC50 | 6 | — | |
OUURFXJLGVXKRZ
|
7.0 | IC50 | 3 | — | |
QRHLGEHZPDSLFJ
|
7.0 | IC50 | 2 | — | |
VUHJPUTWXDGMAY
|
7.0 | IC50 | 3 | — | |
XIPXQEFITCCNMM
|
7.0 | IC50 | 3 | — | |
XWAAKVKNHUQQFW
|
7.0 | IC50 | 3 | Yes | |
YMHSMYQKKBITTG
|
7.0 | IC50 | 3 | — | |
YYJKKZBMQNEKLK
|
7.0 | IC50 | 2 | — | |
YZNIHXUBUWEUCM
|
7.0 | IC50 | 14 | — | |
ZLTJYNGNTXUNQF
|
7.0 | IC50 | 2 | — | |
DPRNXTSMYVCYLJ
|
7.0 | IC50 | 13 | — | |
FLBNLJLONKAPLR
|
6.9 | Kd | 31 | — | |
GFHVYXFCSPKJGR
|
6.9 | IC50 | 3 | — | |
MOXXQFNQDDSJHT
|
6.9 | Ki | 6 | — | |
FJZYDLSIPJYWLO
|
6.9 | IC50 | 3 | — | |
LCTXEDCNMOYBPS
|
6.9 | IC50 | 3 | — | |
XYSMLTDOEYEKPK
|
6.9 | IC50 | 3 | — | |
BCWVVERKADMJGG
|
6.9 | IC50 | 3 | Yes | |
DXZISSBXMPGCOF
|
6.9 | IC50 | 3 | Yes | |
JWNPDZNEKVCWMY
|
6.9 | Kd | 57 | Yes | |
OUDNHJQPMQFCDI
|
6.9 | IC50 | 4 | — | |
RKGQENOGQBXEPA
|
6.9 | IC50 | 6 | — | |
RVOAIHCSSLBNKH
|
6.9 | IC50 | 3 | — | |
VNBRGSXVFBYQNN
|
6.9 | IC50 | 22 | Yes | |
ZLXUXNOXPKFKQF
|
6.9 | IC50 | 2 | — | |
HJPRIMCYDHVCTJ
|
6.9 | IC50 | 3 | — | |
MNEXDVSJIUQQRH
|
6.9 | IC50 | 6 | — |