Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XNEPVLVYFUGJLF
|
7.1 | Ki | 27 | — | |
XSLOCCCIKXFJLR
|
7.1 | IC50 | 3 | — | |
YTSDNPLOCDVGNB
|
7.1 | IC50 | 8 | — | |
ZRTDSOVGBJZNBQ
|
7.1 | Ki | 3 | — | |
CCUWZTRFTGLQCV
|
7.1 | IC50 | 5 | Yes | |
KDRZYBZCBYKLPL
|
7.1 | IC50 | 2 | — | |
OINFPVXXMDBRDU
|
7.1 | IC50 | 3 | — | |
PTILEOLOGGMFCS
|
7.1 | IC50 | 2 | — | |
SDVAHCXGDGYWFA
|
7.1 | IC50 | 12 | — | |
XTPDXOIFCVXBFL
|
7.1 | IC50 | 3 | — | |
GZBRMTRCRSMBNA
|
7.1 | IC50 | 2 | — | |
KHIWVHWOVLFXIZ
|
7.1 | IC50 | 2 | — | |
KKVYYGGCHJGEFJ
|
7.1 | IC50 | 6 | Yes | |
ORQCQXMGDYAIOI
|
7.1 | IC50 | 6 | — | |
YJAHLZMTOSJPLA
|
7.1 | IC50 | 2 | — | |
FOORTUZRHZKYIF
|
7.1 | IC50 | 3 | — | |
UHIZYQVRKSWIFO
|
7.1 | Kd | 3 | — | |
GKYIMGQLHMZWQQ
|
7.1 | IC50 | 3 | — | |
HRVYRTCRDJPACP
|
7.1 | IC50 | 3 | — | |
PHVRYQBXECZHNT
|
7.1 | IC50 | 2 | — | |
XTZUWEGTTUIMBG
|
7.1 | Ki | 9 | — | |
CXDZGSNFZYGQSZ
|
7.0 | IC50 | 4 | Yes | |
WHOHIBXOMRSQNS
|
7.0 | IC50 | 3 | — | |
FIENVLBRUWEWDS
|
7.0 | IC50 | 3 | Yes | |
KNHHEGBUUFWWFF
|
7.0 | IC50 | 3 | Yes | |
MFIFUEVAYDVUNR
|
7.0 | IC50 | 3 | — | |
OSVUGUHRKMMBSE
|
7.0 | Kd | 170 | — | |
PCSKFQHKWWNIKM
|
7.0 | IC50 | 7 | — | |
SRTJPDZXTXFJPF
|
7.0 | IC50 | 2 | — | |
YRCHYHRCBXNYNU
|
7.0 | Kd | 13 | — | |
JRKYKAKARRYSSS
|
7.0 | IC50 | 14 | Yes | |
KHDZTOGFCVNLOZ
|
7.0 | IC50 | 2 | — | |
LVXJQMNHJWSHET
|
7.0 | IC50 | 7 | — | |
NXSJMRCTGYTSTK
|
7.0 | Kd | 200 | — | |
OKRHYXZXYNXSAO
|
7.0 | IC50 | 3 | Yes | |
PJFDUIVXIFHGSE
|
7.0 | IC50 | 3 | — | |
PTTXMHGPBHSAPT
|
7.0 | IC50 | 5 | Yes | |
SGCBBVKTBTZXBX
|
7.0 | IC50 | 2 | — | |
SNINXEPVBOIZBX
|
7.0 | IC50 | 3 | — | |
NIKYELXINWPOQX
|
7.0 | IC50 | 3 | — | |
XMHIFHZIDAUFLT
|
7.0 | IC50 | 3 | — | |
XYFPWWZEPKGCCK
|
7.0 | Ki | 7 | — | |
AIQDZMUPVYDVLB
|
7.0 | Ki | 48 | — | |
BPMIILWVKNVIKR
|
7.0 | IC50 | 6 | Yes | |
CEUSZLVORFRBCV
|
7.0 | IC50 | 13 | — | |
DMKUCUYQRJKWJF
|
7.0 | Ki | 3 | — | |
GTMDZIKJMWLLBV
|
7.0 | Ki | 3 | — | |
HXHAJRMTJXHJJZ
|
7.0 | Ki | 52 | Yes | |
IDAYTJFWXHMPGK
|
7.0 | Ki | 3 | — | |
KTEIFNKAUNYNJU
|
7.0 | Ki | 48 | — |