Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QVMGDDAULZLNOQ
|
7.2 | Ki | 3 | — | |
ROAQTOJEPYCOEK
|
7.2 | IC50 | 2 | — | |
XCHWBXBDZRJVDP
|
7.2 | Ki | 51 | — | |
XFWUTMHVDGPWLH
|
7.2 | Ki | 75 | — | |
XKFTZKGMDDZMJI
|
7.2 | Ki | 56 | — | |
YULUVWHIOGBTPX
|
7.2 | IC50 | 4 | Yes | |
ZJEYVWREWRETNW
|
7.2 | IC50 | 3 | — | |
ZVPDNRVYHLRXLX
|
7.2 | IC50 | 35 | Yes | |
FVSUKLKFSDSIEF
|
7.2 | IC50 | 4 | — | |
SILANKVZJSUJHJ
|
7.2 | IC50 | 9 | — | |
STDSMFMGPYMGRQ
|
7.2 | IC50 | 3 | Yes | |
YEVPZIUDTUZJGY
|
7.2 | IC50 | 3 | Yes | |
QTJHBCKEZSYXTG
|
7.2 | IC50 | 3 | — | |
XXJWYDDUDKYVKI
|
7.2 | Kd | 52 | — | |
DAIZZWZDMLDKTD
|
7.2 | IC50 | 2 | — | |
GMIVUSAKVGKIOC
|
7.2 | IC50 | 4 | Yes | |
IYCITBYBDPSBBJ
|
7.2 | IC50 | 6 | — | |
NJSMJBCABAFTHE
|
7.2 | IC50 | 2 | Yes | |
PEZXRLMFGPTMLG
|
7.2 | IC50 | 2 | — | |
PGQWALGGBUYLQF
|
7.2 | IC50 | 12 | — | |
HHZIURLSWUIHRB
|
7.2 | IC50 | 57 | Yes | |
XKZQZMSAWVDRSP
|
7.2 | IC50 | 39 | Yes | |
ZRYMMWAJAFUANM
|
7.2 | IC50 | 7 | — | |
DKZYXHCYPUVGAF
|
7.1 | Kd | 112 | — | |
GXSZEJJGRAAVEG
|
7.1 | IC50 | 3 | — | |
JOOXLOJCABQBSG
|
7.1 | Kd | 139 | — | |
XTXBDMYKIBMUHQ
|
7.1 | IC50 | 2 | — | |
JKYQBRXMMOIBLS
|
7.1 | IC50 | 3 | — | |
VTJHGMZHVOXJPG
|
7.1 | IC50 | 15 | — | |
FEGRQUWSKADGSP
|
7.1 | IC50 | 6 | Yes | |
HPTVFAXXEWQCOC
|
7.1 | IC50 | 3 | — | |
ZCWNSFCDGJTSOG
|
7.1 | IC50 | 3 | — | |
DJNWXYTWORPJNI
|
7.1 | IC50 | 3 | Yes | |
IVKWJLVMIVBKDX
|
7.1 | IC50 | 2 | — | |
LMAZTHVENPJMML
|
7.1 | IC50 | 2 | — | |
YCGAVAFYTUFYPA
|
7.1 | IC50 | 6 | Yes | |
YEUIDIRYOPOAPU
|
7.1 | IC50 | 5 | Yes | |
BDPBZUHWAVABDM
|
7.1 | Ki | 11 | — | |
CZQVOIDVDAVDFW
|
7.1 | Ki | 18 | — | |
GHWPJPRJEAOHFY
|
7.1 | IC50 | 6 | Yes | |
GJKVMXDBPDDFHI
|
7.1 | Ki | 27 | — | |
HHVUDVWMACNSOB
|
7.1 | IC50 | 4 | Yes | |
JTRNNNVASYCTLO
|
7.1 | Ki | 14 | — | |
KMVCEFDNCZLTGI
|
7.1 | IC50 | 3 | — | |
KNACLJBHKVSTDL
|
7.1 | Ki | 40 | — | |
KVXUSGCDEMAYHI
|
7.1 | Ki | 4 | — | |
LCHCMNPPJLRNHX
|
7.1 | Ki | 3 | — | |
LVECPYVAIBNSRV
|
7.1 | Ki | 33 | — | |
OWRXHGAFWZFFCW
|
7.1 | Ki | 113 | — | |
VQRJYECHVOWPDV
|
7.1 | IC50 | 6 | Yes |