Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QMXSHAJJEPUPLY
|
7.3 | IC50 | 2 | — | |
QOXFMUBWQHGRRX
|
7.3 | IC50 | 3 | — | |
QUFURWJAQILIFO
|
7.3 | IC50 | 9 | — | |
RBBBWMGEVIGGPY
|
7.3 | IC50 | 3 | — | |
RQOUEKWRKZQVRU
|
7.3 | IC50 | 3 | — | |
SILNPGWUEYVWOG
|
7.3 | IC50 | 3 | — | |
SRSSGGWPOCYTRY
|
7.3 | IC50 | 3 | — | |
SUIOCBDUXFNRHM
|
7.3 | IC50 | 3 | — | |
TUTCULUSRKMBLE
|
7.3 | IC50 | 4 | — | |
UCGNNLHUIWRSMT
|
7.3 | IC50 | 2 | — | |
UCYLZNWZKDYXGF
|
7.3 | IC50 | 2 | — | |
UDOPWNZLOSLIPA
|
7.3 | IC50 | 2 | — | |
UPGMKOOJQCKFAP
|
7.3 | IC50 | 2 | — | |
UXOKXKVHWDWUBP
|
7.3 | IC50 | 2 | — | |
VNGLFSKNXAELLE
|
7.3 | IC50 | 2 | — | |
VYOPZAZSNZNKMO
|
7.3 | IC50 | 3 | — | |
WIUYFJQWJMBTCE
|
7.3 | Ki | 2 | — | |
WMCSRBOBVVEYKX
|
7.3 | IC50 | 2 | — | |
WWFQRNJUOGZJQS
|
7.3 | IC50 | 3 | — | |
XVNMCGWDHIIBST
|
7.3 | IC50 | 3 | — | |
YILVNDUVPVMTNQ
|
7.3 | IC50 | 4 | — | |
YOMAOPPNVBYEOX
|
7.3 | IC50 | 3 | — | |
YSAFNKIWUWRWQG
|
7.3 | IC50 | 3 | — | |
YYZHWIPIBVKARI
|
7.3 | IC50 | 3 | — | |
YZJWZRFMAXAQID
|
7.3 | IC50 | 3 | — | |
ZBYCACUNROWHAG
|
7.3 | IC50 | 2 | — | |
ZDWYSTGDXIBDEO
|
7.3 | IC50 | 3 | — | |
ZODREUNJEPMICB
|
7.3 | IC50 | 3 | — | |
JRSWBWSVEXDHPO
|
7.2 | IC50 | 3 | — | |
CVWXJKQAOSCOAB
|
7.2 | IC50 | 35 | — | |
DPLYERNYYUCIOC
|
7.2 | IC50 | 2 | — | |
LQIXQCXHUWUIFK
|
7.2 | IC50 | 3 | — | |
NHVGQRASKRTWLZ
|
7.2 | IC50 | 5 | Yes | |
XJPZZAAKTVLITO
|
7.2 | IC50 | 3 | Yes | |
ZRFDOJZJWLQZJB
|
7.2 | IC50 | 2 | — | |
GFHVYXFCSPKJGR
|
7.2 | IC50 | 3 | — | |
ZODREUNJEPMICB
|
7.2 | IC50 | 3 | — | |
AYPFKZQQTSLEJG
|
7.2 | IC50 | 2 | Yes | |
MLDQJTXFUGDVEO
|
7.2 | IC50 | 85 | Yes | |
ONQZVCBYRFYYFU
|
7.2 | IC50 | 3 | — | |
YJMWLWKXYJRSBL
|
7.2 | IC50 | 3 | — | |
BLYRPGBSIKAIAU
|
7.2 | IC50 | 24 | Yes | |
DZEXCTFXOCMPSR
|
7.2 | IC50 | 3 | — | |
GCIKSSRWRFVXBI
|
7.2 | Kd | 109 | Yes | |
KTUFNOKKBVMGRW
|
7.2 | Kd | 38 | Yes | |
QTTGVGLTCILDCA
|
7.2 | IC50 | 7 | — | |
GALVWTFFXPRMQM
|
7.2 | Ki | 20 | — | |
HKZKELVPGXJIMW
|
7.2 | Ki | 41 | — | |
OGNYUTNQZVRGMN
|
7.2 | Ki | 16 | Yes | |
OQCCIANNQMEJOB
|
7.2 | IC50 | 3 | — |