Target Details
| UniProt AC | P06239 |
|---|---|
| Gene Symbol | LCK |
| Protein Name | Tyrosine-protein kinase Lck |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) PF00017 (SH2) PF00018 (SH3_1) |
Summary
- Multi-target molecules 1,537
- Clinical molecules 323
- Avg pChEMBL 7.15
KEGG Pathways (11)
- Human T-cell leukemia virus 1 infection
- IgSF CAM signaling
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Yersinia infection
Associated Diseases (1)
Active Molecules (1,537)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VTKMDZCBBTUOHA
|
11.0 | IC50 | 4 | — | |
CAQLNQYCCKYWJX
|
10.4 | Ki | 5 | Yes | |
IZZSAERQBCCMSM
|
10.2 | IC50 | 4 | — | |
DVRSTRMZTAPMKO
|
9.7 | IC50 | 10 | Yes | |
LQYPBKQMDVWUGO
|
9.7 | Kd | 2 | — | |
YEIASMOUYNOXGA
|
9.7 | IC50 | 5 | — | |
PHXJVRSECIGDHY
|
9.6 | IC50 | 59 | — | |
UTVABCSMEKUFLJ
|
9.5 | IC50 | 7 | Yes | |
FNYWVPCDXNSWSG
|
9.5 | IC50 | 4 | — | |
ZYDVIGWWZRPSHL
|
9.5 | IC50 | 3 | — | |
PNPBIVBXLHZEEY
|
9.4 | IC50 | 3 | — | |
QXQVIBRVLYDXEY
|
9.4 | IC50 | 4 | — | |
SLDNXLAQRVJNJO
|
9.4 | IC50 | 5 | Yes | |
DGUSFVFTIHATAT
|
9.3 | IC50 | 5 | Yes | |
FIWBNUYYYKCFHG
|
9.3 | IC50 | 4 | — | |
RPZCFPLDPHTRPE
|
9.3 | IC50 | 3 | — | |
YGLITMMDQOZAHY
|
9.3 | IC50 | 3 | — | |
BPLTVYXMXOYIBK
|
9.2 | IC50 | 9 | — | |
BPLTVYXMXOYIBK
|
9.2 | IC50 | 6 | — | |
DXLSIJUGUJXUIP
|
9.2 | IC50 | 4 | — | |
GSUDSWBWGLGBGN
|
9.2 | IC50 | 3 | — | |
VSJXTUFWPAOYLC
|
9.2 | IC50 | 11 | Yes | |
QONHZAOUSLDLOE
|
9.1 | IC50 | 3 | — | |
SYWUIAOLWMUYTP
|
9.1 | IC50 | 3 | — | |
SYFFKWAKQHJCOM
|
9.1 | IC50 | 3 | — | |
SYFFKWAKQHJCOM
|
9.1 | IC50 | 3 | — | |
SSDFTYWIYVWCIE
|
9.1 | IC50 | 3 | — | |
JPYUSZIWNUNSCD
|
9.1 | IC50 | 2 | — | |
ZQKNIPQNEVNCDY
|
9.0 | IC50 | 8 | — | |
ZBNZXTGUTAYRHI
|
9.0 | IC50 | 102 | Yes | |
CQKMMXFWQMPMFC
|
9.0 | IC50 | 3 | — | |
CREAAGUFOMLCKF
|
9.0 | IC50 | 3 | Yes | |
CVTIVBFOLJQENW
|
9.0 | IC50 | 3 | — | |
DPLQMNPQGDUUNM
|
9.0 | IC50 | 3 | Yes | |
FCPPQNZGDIZFLT
|
9.0 | IC50 | 3 | Yes | |
GWYGTWXYFRMPAH
|
9.0 | IC50 | 3 | Yes | |
IEIWHASYQUBSLR
|
9.0 | IC50 | 3 | — | |
JBUBKVHDFJCRSZ
|
9.0 | IC50 | 3 | Yes | |
JRNCQPTXPIPDSZ
|
9.0 | IC50 | 4 | — | |
MCCCQFAOMZMZKE
|
9.0 | Ki | 52 | — | |
NKKSIIYIDSJFSX
|
9.0 | IC50 | 3 | Yes | |
OQKMFDJSKWESCR
|
9.0 | IC50 | 4 | Yes | |
PELUCDAGCYAICS
|
9.0 | IC50 | 3 | Yes | |
PRFGCHAHYIAXCL
|
9.0 | IC50 | 3 | Yes | |
QRDWGUVCGQETNO
|
9.0 | IC50 | 4 | Yes | |
RBXYGQNZRVPDNB
|
9.0 | Ki | 34 | — | |
SSDFTYWIYVWCIE
|
9.0 | IC50 | 17 | — | |
UPXVJAHQYQWZKZ
|
9.0 | IC50 | 3 | Yes | |
WFRLFWGASBLYTC
|
9.0 | IC50 | 15 | Yes | |
XLLRJKPTDUSPNM
|
9.0 | IC50 | 3 | — |