Target Details
| UniProt AC | P06213 |
|---|---|
| Gene Symbol | INSR |
| Protein Name | Insulin receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF17870 (Insulin_TMD) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 656
- Clinical molecules 33
- Avg pChEMBL 7.55
KEGG Pathways (23)
- AMPK signaling pathway
- Adherens junction
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Diabetic cardiomyopathy
- FoxO signaling pathway
- HIF-1 signaling pathway
- Hormone signaling
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Non-alcoholic fatty liver disease
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Phospholipase D signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (656)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
LIBCMUMCEYECFM
|
7.0 | IC50 | 2 | — | |
OGBBOXLWGHVVPQ
|
7.0 | IC50 | 3 | — | |
HKSZLNNOFSGOKW
|
7.0 | Kd | 213 | — | |
JZMFNCMUNMDDDE
|
7.0 | IC50 | 2 | — | |
KZKWIMSZKNQYFJ
|
7.0 | IC50 | 2 | — | |
CKOFEFWHTQQMLF
|
6.9 | IC50 | 2 | — | |
PFZIQVWSNDVNQV
|
6.9 | IC50 | 2 | — | |
ZCCPLJOKGAACRT
|
6.9 | Kd | 599 | — | |
VAWRVYSDUDQVTO
|
6.9 | IC50 | 2 | — | |
XBYVOPRDASFDMY
|
6.9 | Ki | 42 | — | |
XHORJSJFHVABEA
|
6.9 | Ki | 49 | — | |
YEHCNYAQEBQCCS
|
6.9 | Ki | 74 | — | |
ZCCJKVBTHCOISJ
|
6.9 | Ki | 46 | — | |
ZHTVWJDQZBBZHV
|
6.9 | Ki | 9 | — | |
ADYZVNMLQOHYDE
|
6.9 | IC50 | 2 | — | |
BCSHRERPHLTPEE
|
6.9 | IC50 | 3 | — | |
KYODHQKKLBGUED
|
6.9 | IC50 | 3 | — | |
WAGRWRIWWPGPDN
|
6.9 | IC50 | 2 | — | |
WDRXGELIQZMTRU
|
6.9 | IC50 | 3 | — | |
DVAYUYCZMIQXLC
|
6.8 | IC50 | 2 | — | |
MJEHBQIPZHTMNZ
|
6.8 | IC50 | 2 | — | |
NCDRKKZNMOSYQQ
|
6.8 | IC50 | 2 | — | |
ALKJNCZNEOTEMP
|
6.8 | Kd | 55 | — | |
ILVXQPRFMVXZRH
|
6.8 | IC50 | 2 | — | |
MOAIIOFZEWYTIP
|
6.8 | IC50 | 3 | — | |
PURNBEBZVYETFI
|
6.8 | IC50 | 3 | — | |
IMUUEXXPJMRNER
|
6.8 | IC50 | 2 | — | |
MIPFBSHTKYTXKN
|
6.8 | IC50 | 2 | — | |
PCAABRMAORWYHN
|
6.8 | IC50 | 2 | — | |
DPRNXTSMYVCYLJ
|
6.8 | IC50 | 13 | — | |
FQUQLTHTCSOGBY
|
6.8 | IC50 | 3 | — | |
JMHQUQCLIVNTHT
|
6.8 | Ki | 24 | — | |
MUAICZWSFWUFNA
|
6.8 | IC50 | 2 | — | |
UGEJLCNSVIVALC
|
6.8 | Ki | 41 | — | |
WUWDLXZGHZSWQZ
|
6.8 | Ki | 41 | — | |
XOOAAYRIVATZNM
|
6.8 | Ki | 55 | — | |
ZBAFXJXHSORURK
|
6.8 | IC50 | 4 | — | |
FAUWHVUDSIQEKF
|
6.8 | IC50 | 3 | — | |
KXWHALCUEMIJMC
|
6.8 | IC50 | 3 | — | |
ZRFJCNOHKKQRSS
|
6.8 | IC50 | 3 | — | |
YXLQJZQRBVGUCM
|
6.8 | IC50 | 2 | — | |
AXFCKENUDNTMRB
|
6.8 | IC50 | 2 | — | |
CCVGHLZQHJYDAI
|
6.8 | IC50 | 3 | — | |
FXYPQFBJRKMLDS
|
6.8 | IC50 | 4 | — | |
GHJLZINDIHSFBZ
|
6.8 | IC50 | 2 | — | |
ILSYFQQNAQIMBK
|
6.8 | IC50 | 2 | — | |
HNIJEISPKOYRAL
|
6.7 | IC50 | 2 | — | |
QLNWZYTUBBNBEL
|
6.7 | IC50 | 2 | — | |
COPINYWCESNOFK
|
6.7 | IC50 | 3 | — | |
COPINYWCESNOFK
|
6.7 | IC50 | 3 | — |