Target Details
| UniProt AC | P06213 |
|---|---|
| Gene Symbol | INSR |
| Protein Name | Insulin receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF17870 (Insulin_TMD) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 656
- Clinical molecules 33
- Avg pChEMBL 7.55
KEGG Pathways (23)
- AMPK signaling pathway
- Adherens junction
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Diabetic cardiomyopathy
- FoxO signaling pathway
- HIF-1 signaling pathway
- Hormone signaling
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Non-alcoholic fatty liver disease
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Phospholipase D signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (656)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
POQOPHUTAQLSQX
|
7.7 | IC50 | 2 | — | |
QQWUGDVOUVUTOY
|
7.7 | IC50 | 231 | Yes | |
RJLMIOROTJPHHU
|
7.7 | IC50 | 2 | — | |
HQHWKSPSJJCZPM
|
7.7 | IC50 | 2 | — | |
NBRHHKSETRXRCP
|
7.7 | IC50 | 2 | — | |
XJPVLMZNDIDZRP
|
7.7 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
7.7 | IC50 | 118 | — | |
JHZOJILVCGEIFB
|
7.6 | IC50 | 3 | — | |
FXDWNCFVVOSWKM
|
7.6 | IC50 | 5 | Yes | |
XZXHXSATPCNXJR
|
7.6 | Kd | 165 | Yes | |
RYYNGWLOYLRZLK
|
7.6 | Ki | 104 | — | |
ULMCFLZUGRSEQA
|
7.6 | Ki | 17 | — | |
ZNLXCLMQEIQSAS
|
7.6 | IC50 | 2 | — | |
ZWVZORIKUNOTCS
|
7.6 | Ki | 69 | — | |
DRYWSMFQHZVTJK
|
7.6 | IC50 | 3 | — | |
CBCRRZVVZMJUTF
|
7.5 | IC50 | 3 | — | |
OYFMIXVMTCYDNY
|
7.5 | IC50 | 6 | Yes | |
FVAJHBVTGUIFMD
|
7.5 | IC50 | 2 | — | |
JQMFATNHUYQNBF
|
7.5 | IC50 | 2 | — | |
SBWJIBNYPHVCIY
|
7.5 | IC50 | 2 | — | |
YEFKWCQOENUXOA
|
7.5 | IC50 | 2 | — | |
LNDWTKJDTCDSMV
|
7.5 | IC50 | 2 | — | |
UTPGMJXBHKIZDL
|
7.5 | IC50 | 2 | — | |
RFZOHHKCEHQQBE
|
7.5 | IC50 | 3 | — | |
RPLNJVBSDCLPJC
|
7.4 | IC50 | 2 | — | |
WQROZMCEHXFGBY
|
7.4 | IC50 | 2 | — | |
LSFLAQVDISHMNB
|
7.4 | Ki | 13 | — | |
MVJMMLFMPWITEJ
|
7.4 | Ki | 110 | — | |
NFMGZVPRGVERNN
|
7.4 | Ki | 44 | — | |
OTVCFDOYUHREFJ
|
7.4 | Ki | 26 | — | |
UYJNQQDJUOUFQJ
|
7.4 | IC50 | 68 | — | |
SKXAZUOZHANICG
|
7.4 | IC50 | 3 | — | |
HHXONKYVQVDMAS
|
7.4 | IC50 | 3 | — | |
MBDRYJSNQAFOKD
|
7.4 | IC50 | 2 | — | |
MOSKATHMXWSZTQ
|
7.4 | IC50 | 16 | Yes | |
VKBFHTIUXUCYRQ
|
7.3 | Ki | 66 | — | |
CAIAMTHZGVFCNA
|
7.3 | IC50 | 2 | — | |
GVHNKGKLBRLAOO
|
7.3 | IC50 | 2 | — | |
ADLPKFFMGIJZIM
|
7.3 | Ki | 44 | — | |
DRPOUFRDMKUUKI
|
7.3 | IC50 | 2 | — | |
ITNPURPVZHRALQ
|
7.3 | IC50 | 2 | — | |
PKCDDUHJAFVJJB
|
7.3 | IC50 | 13 | — | |
KARRXYMCFAILBZ
|
7.3 | IC50 | 2 | — | |
SLFIVXXZOYCJGB
|
7.3 | IC50 | 3 | — | |
MZGDIKYASHMRSG
|
7.3 | IC50 | 2 | — | |
IBXPUECEDDUZFG
|
7.3 | IC50 | 3 | — | |
IFENGTVBYLDKRT
|
7.2 | IC50 | 2 | — | |
IWKVFBINMMDGNH
|
7.2 | IC50 | 3 | — | |
JVCFOBYUGHIPJO
|
7.2 | IC50 | 2 | — | |
KXTIIOOGQPWWGE
|
7.2 | IC50 | 6 | Yes |