Target Details
| UniProt AC | P06213 |
|---|---|
| Gene Symbol | INSR |
| Protein Name | Insulin receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF17870 (Insulin_TMD) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 656
- Clinical molecules 33
- Avg pChEMBL 7.55
KEGG Pathways (23)
- AMPK signaling pathway
- Adherens junction
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Diabetic cardiomyopathy
- FoxO signaling pathway
- HIF-1 signaling pathway
- Hormone signaling
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Non-alcoholic fatty liver disease
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Phospholipase D signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (656)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
LUUOHJCBIJQUBZ
|
9.0 | IC50 | 2 | — | |
MAYBCHWSKBRUDW
|
9.0 | IC50 | 2 | — | |
RXYPFHYDNNLDSN
|
9.0 | IC50 | 2 | — | |
HXZDICYKFAOZLE
|
8.8 | IC50 | 6 | Yes | |
LQVXSNNAFNGRAH
|
8.8 | IC50 | 33 | Yes | |
HZTYDQRUAWIZRE
|
8.8 | IC50 | 40 | Yes | |
GUUUIDZRGJYTMH
|
8.7 | IC50 | 2 | — | |
HXFVZOYBPSIUHZ
|
8.7 | IC50 | 2 | — | |
AUQYWFVTSGUQCD
|
8.7 | IC50 | 2 | — | |
GBWMNCWACPCEEQ
|
8.7 | IC50 | 2 | — | |
HFMMOXFTBXCGCO
|
8.7 | IC50 | 2 | — | |
HJERFKFVQHRAML
|
8.7 | IC50 | 2 | — | |
IXPKKOYDMRELAG
|
8.7 | IC50 | 2 | — | |
KXWPCIASWBFLMB
|
8.7 | IC50 | 2 | — | |
MZVQVCMUWUQNFP
|
8.7 | IC50 | 2 | — | |
ODJRLLIFPOKNLG
|
8.7 | IC50 | 2 | — | |
OJOAXIFFWKGMCG
|
8.7 | IC50 | 2 | — | |
YPPZOXGKXXTCAP
|
8.7 | IC50 | 2 | — | |
YRONGIKDOAUNNP
|
8.7 | IC50 | 2 | — | |
YUIOENQMCZQWAY
|
8.7 | IC50 | 2 | — | |
ZBUFIMGFTPZODR
|
8.7 | IC50 | 2 | — | |
BSZHBKNJHFKROD
|
8.7 | IC50 | 2 | — | |
ZWDPQPKCKRVHBW
|
8.7 | IC50 | 2 | — | |
LVBJEZPSLPIGDT
|
8.7 | IC50 | 2 | — | |
RKXGEBJVNGSICG
|
8.7 | IC50 | 3 | — | |
NFZBAKHCVIQLBD
|
8.6 | IC50 | 2 | — | |
NVHYFDRMQSUXBA
|
8.6 | IC50 | 2 | — | |
GHPFQRTVUDXWCC
|
8.6 | Ki | 35 | — | |
DNEAWOPYODVHIL
|
8.6 | IC50 | 2 | — | |
JTUQGTNWWPMBKS
|
8.6 | IC50 | 2 | — | |
XJMFPTCMAYQIDJ
|
8.6 | IC50 | 2 | — | |
CJLMCBMDZOAJLV
|
8.5 | IC50 | 2 | — | |
FHDPQTHZTKXVCW
|
8.5 | IC50 | 8 | Yes | |
FJMVOCSRTVXRIV
|
8.5 | IC50 | 2 | — | |
IBDMRAZGYXXBKY
|
8.5 | IC50 | 2 | — | |
PLCWQDVCBVWDJZ
|
8.5 | IC50 | 2 | — | |
IDGLCVJYKNDJCG
|
8.5 | IC50 | 2 | — | |
HMXWMMRCKSDFCV
|
8.5 | IC50 | 10 | Yes | |
DGIKQZFVNNRZMT
|
8.5 | IC50 | 3 | — | |
JMSKTSHWCHAIDU
|
8.5 | IC50 | 2 | — | |
KUQOZTZPJMJBMT
|
8.5 | IC50 | 3 | — | |
UBXWHWZWWVQYGU
|
8.5 | IC50 | 2 | — | |
GMAVZOAXIGWUEM
|
8.4 | IC50 | 2 | — | |
BYWPPTHPCWUJSH
|
8.4 | IC50 | 2 | — | |
IKALKYJLFRWHAR
|
8.4 | IC50 | 2 | — | |
JDFGIOCJMJJUNK
|
8.4 | IC50 | 6 | Yes | |
OLZPYOIWNSDNMX
|
8.4 | IC50 | 2 | — | |
HFTHUIUDNIONGS
|
8.3 | IC50 | 3 | — | |
YLAPHXZIXJJZIH
|
8.3 | IC50 | 2 | — | |
HGXOLSAJHMUDJP
|
8.3 | IC50 | 2 | — |