Target Details
| UniProt AC | P06213 |
|---|---|
| Gene Symbol | INSR |
| Protein Name | Insulin receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF17870 (Insulin_TMD) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 656
- Clinical molecules 33
- Avg pChEMBL 7.55
KEGG Pathways (23)
- AMPK signaling pathway
- Adherens junction
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Diabetic cardiomyopathy
- FoxO signaling pathway
- HIF-1 signaling pathway
- Hormone signaling
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Non-alcoholic fatty liver disease
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Phospholipase D signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (656)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SZCXARSUVUOVCP
|
6.1 | IC50 | 3 | — | |
INIPJCMUHKXHJQ
|
6.1 | IC50 | 6 | Yes | |
MATHWQFCWXKDBA
|
6.1 | IC50 | 2 | — | |
MOWRRSWYFUOCAR
|
6.1 | IC50 | 3 | — | |
QUZLPRLQAANSNR
|
6.1 | IC50 | 3 | — | |
IHCBPZKNVNJFAT
|
6.1 | IC50 | 2 | — | |
DQILXXVPFRTBOV
|
6.1 | IC50 | 2 | — | |
HOQCCNALNBIQIM
|
6.1 | IC50 | 2 | — | |
IOBVCHJTLVPPBR
|
6.1 | Ki | 39 | — | |
MPVGZUGXCQEXTM
|
6.1 | Ki | 61 | Yes | |
NHFDRBXTEDBWCZ
|
6.1 | Ki | 41 | — | |
NHHQJBCNYHBUSI
|
6.1 | Ki | 220 | — | |
VCLHKFSMXAYHRB
|
6.1 | IC50 | 2 | — | |
XBDWKVLCDCUNHH
|
6.1 | Ki | 18 | — | |
HCQWDCIGBDDWLZ
|
6.1 | IC50 | 3 | — | |
LVFUTSYJVODLJN
|
6.1 | IC50 | 2 | — | |
PPCDZYRDXIKRDW
|
6.1 | IC50 | 6 | Yes | |
RQTWMVOMNNMRAP
|
6.1 | IC50 | 3 | — | |
VZXLODFBDTXBJK
|
6.1 | IC50 | 2 | — | |
WHUMNDGRLJYAMI
|
6.1 | IC50 | 2 | — | |
ZCTFOPDXSRRCIE
|
6.1 | IC50 | 2 | — | |
GWPQJRDWVXCIBI
|
6.1 | IC50 | 2 | — | |
JOOXLOJCABQBSG
|
6.1 | Kd | 139 | — | |
WDFURCPOBHRTIU
|
6.1 | IC50 | 2 | — | |
AECDBHGVIIRMOI
|
6.0 | IC50 | 7 | — | |
FRHDZWLQTMKUPC
|
6.0 | IC50 | 11 | Yes | |
ROHJEIACUNTGFP
|
6.0 | IC50 | 16 | — | |
UWQCPRVJOPGITM
|
6.0 | IC50 | 2 | — | |
XMKAFTZMVDNUII
|
6.0 | IC50 | 2 | — | |
DUYJMQONPNNFPI
|
6.0 | IC50 | 11 | — | |
NKGBJFZCCPPWIY
|
6.0 | IC50 | 2 | — | |
RZSXKXZMLBUVEC
|
6.0 | IC50 | 2 | — | |
ZKHQZMGFQLTDQH
|
6.0 | IC50 | 3 | — | |
DNRDWKZUFWVTKE
|
6.0 | IC50 | 2 | — | |
FLFKVWGYOJDSOD
|
6.0 | IC50 | 2 | — | |
GEPKFPGFWUHVLZ
|
6.0 | IC50 | 6 | Yes | |
HZUPDOJVKYRRMY
|
6.0 | IC50 | 3 | — | |
RKSKGSQDRZHVPG
|
6.0 | IC50 | 2 | — | |
UYHKCQAFCWYUAF
|
6.0 | IC50 | 2 | — | |
GGJPKPHOWZDYAP
|
6.0 | IC50 | 2 | — | |
LOONVQWRKJLEEG
|
6.0 | IC50 | 8 | — | |
JEDOYASWEYRMNO
|
6.0 | IC50 | 2 | — | |
DBKQWGCVGCVPIP
|
6.0 | Ki | 21 | — | |
GLBZSOQDAOLMGC
|
6.0 | IC50 | 23 | Yes | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
LGHBDVLAHHANMX
|
6.0 | Ki | 53 | — | |
LIBCMUMCEYECFM
|
6.0 | IC50 | 2 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
PCIMPOMGHFNGMS
|
6.0 | IC50 | 7 | — |