Target Details
| UniProt AC | P06213 |
|---|---|
| Gene Symbol | INSR |
| Protein Name | Insulin receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF17870 (Insulin_TMD) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 656
- Clinical molecules 33
- Avg pChEMBL 7.55
KEGG Pathways (23)
- AMPK signaling pathway
- Adherens junction
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Diabetic cardiomyopathy
- FoxO signaling pathway
- HIF-1 signaling pathway
- Hormone signaling
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Non-alcoholic fatty liver disease
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Phospholipase D signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (656)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WINHZLLDWRZWRT
|
6.3 | Kd | 201 | Yes | |
WIXBTAOMGMZCEY
|
6.3 | IC50 | 2 | — | |
FLTLUXCGVBUQLQ
|
6.3 | IC50 | 3 | — | |
KZXIZEAAKHQALQ
|
6.3 | IC50 | 2 | — | |
SVQKJNKAPILWNS
|
6.3 | IC50 | 2 | — | |
RCSMIXJVDRCRBA
|
6.3 | IC50 | 2 | — | |
XJBVBERAWLJSDE
|
6.3 | IC50 | 2 | — | |
AXLAIMYZOBLZAF
|
6.3 | IC50 | 2 | — | |
BJNCGWGKNWXUIL
|
6.3 | IC50 | 3 | Yes | |
DTEATKAMUSGFKQ
|
6.3 | IC50 | 2 | — | |
GOIGYVCVLJOCLG
|
6.3 | IC50 | 2 | — | |
HATRKFPXWDUKPL
|
6.3 | IC50 | 3 | — | |
NWKSLWHGCANTBP
|
6.3 | IC50 | 2 | — | |
PZTMNGIWLGNPHC
|
6.3 | IC50 | 2 | — | |
QXGDVAINKPZMRY
|
6.3 | IC50 | 2 | — | |
BMHPQMHATYLSKA
|
6.2 | IC50 | 2 | — | |
UAVBPSVJXCTZOC
|
6.2 | IC50 | 3 | — | |
CFAYMFXAARPSEQ
|
6.2 | IC50 | 2 | — | |
NBLXWOQTZXCMKV
|
6.2 | IC50 | 3 | — | |
NJPLUFOJYZAGOK
|
6.2 | IC50 | 2 | — | |
GGJPKPHOWZDYAP
|
6.2 | IC50 | 2 | — | |
HTEUQPWFMDGLKN
|
6.2 | IC50 | 6 | Yes | |
GLGNXYJARSMNGJ
|
6.2 | IC50 | 2 | — | |
IUPOUNFOIQBJFD
|
6.2 | IC50 | 2 | — | |
XMKAFTZMVDNUII
|
6.2 | IC50 | 2 | — | |
BETBNWGUKZUUAX
|
6.2 | IC50 | 21 | — | |
GCIKSSRWRFVXBI
|
6.2 | Kd | 109 | Yes | |
HEUSUIRCBWROMH
|
6.2 | Ki | 64 | — | |
IMXLKPSPRSVIRB
|
6.2 | IC50 | 4 | — | |
OADRBDVURCEKRP
|
6.2 | Ki | 44 | — | |
PAIFYAZSILXLBO
|
6.2 | Ki | 26 | — | |
QFHPSDWMERSJDZ
|
6.2 | IC50 | 4 | — | |
SFPWNTQWFFNJIH
|
6.2 | Ki | 48 | — | |
UEAQQAPWVJTBSU
|
6.2 | IC50 | 2 | — | |
YIHUYKCYYKDOHR
|
6.2 | IC50 | 2 | — | |
LAJAFFLJAJMYLK
|
6.2 | IC50 | 17 | — | |
OBLWMYNSTHSSDS
|
6.2 | IC50 | 6 | Yes | |
QDOTUHIGOCRMSM
|
6.2 | IC50 | 3 | — | |
SHZQPUOQOSUSFR
|
6.2 | IC50 | 2 | — | |
CTZVCMKQQAGWBA
|
6.2 | IC50 | 3 | — | |
FILMJNHPVCSZTN
|
6.2 | IC50 | 2 | — | |
NMTCBMKWFHUPEP
|
6.2 | IC50 | 2 | — | |
RPUSLEYUMRGACQ
|
6.2 | IC50 | 3 | — | |
COPINYWCESNOFK
|
6.2 | IC50 | 3 | — | |
CTOIWJDYNIQZEG
|
6.2 | IC50 | 2 | — | |
CWXBESRGEPLREF
|
6.2 | IC50 | 4 | — | |
YUEGRPWDOBJWDW
|
6.2 | IC50 | 3 | — | |
COZPORUDEQRJMN
|
6.1 | IC50 | 3 | — | |
KHBUKOVUBUJCGM
|
6.1 | IC50 | 2 | — | |
PZPRNRYGJJTJJT
|
6.1 | IC50 | 2 | — |