Target Details
| UniProt AC | P06213 |
|---|---|
| Gene Symbol | INSR |
| Protein Name | Insulin receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF17870 (Insulin_TMD) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) |
Summary
- Multi-target molecules 656
- Clinical molecules 33
- Avg pChEMBL 7.55
KEGG Pathways (23)
- AMPK signaling pathway
- Adherens junction
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Diabetic cardiomyopathy
- FoxO signaling pathway
- HIF-1 signaling pathway
- Hormone signaling
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Non-alcoholic fatty liver disease
- Ovarian steroidogenesis
- PI3K-Akt signaling pathway
- Phospholipase D signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (656)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YRWVTRIPDNRHAC
|
6.5 | IC50 | 2 | — | |
LLGFEJJPLZCCQL
|
6.5 | IC50 | 10 | Yes | |
PLHLUTRXYOYAMQ
|
6.5 | IC50 | 2 | — | |
CAXBBGZEJPMNQW
|
6.5 | IC50 | 2 | — | |
GCBJDOWIQHMCMR
|
6.5 | Ki | 84 | — | |
IRMXYUDLJRENSZ
|
6.5 | IC50 | 2 | — | |
JMPYOBZSMKYCFM
|
6.5 | IC50 | 4 | — | |
MHCPAORAYMTGCZ
|
6.5 | Ki | 37 | — | |
OWFXKTOLFUQPDJ
|
6.5 | Ki | 36 | — | |
PRGUDNWYEAHEQM
|
6.5 | IC50 | 2 | — | |
QVDPABSEHBAHOD
|
6.5 | IC50 | 2 | — | |
SRUYMJRFVGLQDV
|
6.5 | Ki | 37 | — | |
WKCUMDOOJAZCDE
|
6.5 | IC50 | 4 | — | |
XBAUQTADQOFONU
|
6.5 | IC50 | 3 | — | |
YHPAJLKMWLZGMO
|
6.5 | IC50 | 2 | — | |
IFFBVWMQEXWQPC
|
6.5 | IC50 | 2 | — | |
CQYAVXIHIFJOCO
|
6.5 | IC50 | 2 | — | |
CQYAVXIHIFJOCO
|
6.5 | IC50 | 2 | — | |
GUBJNPWVIUFSTR
|
6.5 | Kd | 103 | — | |
HQZLQPMNIPRNBQ
|
6.5 | IC50 | 3 | — | |
MIXZFFBSISECDQ
|
6.5 | IC50 | 2 | — | |
MFPZJISOIZABEX
|
6.5 | IC50 | 2 | — | |
MNUHUBSGVGOPGM
|
6.5 | IC50 | 3 | — | |
MQCNUAFNUAISQK
|
6.5 | IC50 | 3 | — | |
AZXPDNLEMGQMQS
|
6.5 | IC50 | 2 | — | |
LZNLVKVRHVELDP
|
6.5 | IC50 | 3 | — | |
OOXXIVRLCXQRPS
|
6.5 | IC50 | 2 | — | |
QXOZRBMOILEYGU
|
6.5 | IC50 | 2 | — | |
VZWIFOMPMPZKRT
|
6.5 | IC50 | 2 | — | |
ZGBMHLAMQUGCST
|
6.5 | IC50 | 2 | — | |
XSJJLTUTXVNLLI
|
6.5 | IC50 | 3 | — | |
ZCIQMENOTTVELZ
|
6.5 | IC50 | 3 | — | |
GKYYNGUNIGRDPF
|
6.4 | IC50 | 2 | — | |
LMBKLNFIUZRASR
|
6.4 | IC50 | 2 | — | |
WGEGYCKWUWQOIP
|
6.4 | IC50 | 3 | — | |
HLDBRFJDIQDEFJ
|
6.4 | IC50 | 2 | — | |
UARGTPGGYPAFBV
|
6.4 | IC50 | 2 | — | |
YJFOJLPHZMITIB
|
6.4 | IC50 | 2 | — | |
DUKPHDKHHJUGAK
|
6.4 | IC50 | 4 | — | |
FLTLUXCGVBUQLQ
|
6.4 | IC50 | 3 | — | |
GRALRZJBEGFAHQ
|
6.4 | IC50 | 2 | — | |
RWMHHWHCWTVGOV
|
6.4 | IC50 | 2 | — | |
MCTMVANAYQPALM
|
6.4 | IC50 | 2 | — | |
OUCKZVRLUAQTBL
|
6.4 | IC50 | 3 | — | |
FUMCKNCUEAQHCV
|
6.4 | Ki | 103 | — | |
KTEIFNKAUNYNJU
|
6.4 | Ki | 48 | — | |
KWVOXKDNAQPLPP
|
6.4 | IC50 | 2 | — | |
LYNBNVBMAGDJRW
|
6.4 | Ki | 81 | — | |
RSZZFPDNNOBJGC
|
6.4 | IC50 | 2 | — | |
ULHGAQSVFPOUDY
|
6.4 | Ki | 43 | — |