Target Details
| UniProt AC | P05771 |
|---|---|
| Gene Symbol | PRKCB |
| Protein Name | Protein kinase C beta type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 457
- Clinical molecules 133
- Avg pChEMBL 7.4
KEGG Pathways (73)
- AGE-RAGE signaling pathway in diabetic complications
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- B cell receptor signaling pathway
- Calcium signaling pathway
- Carbohydrate digestion and absorption
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin resistance
- Insulin secretion
- Leishmaniasis
- Leukocyte transendothelial migration
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Wnt signaling pathway
- mTOR signaling pathway
Active Molecules (457)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QGXMVFJEJZPAES
|
7.3 | Ki | 2 | — | |
QEPARSUKSLKMMO
|
7.2 | IC50 | 7 | Yes | |
YZCCPMVBDYCXOW
|
7.2 | IC50 | 3 | — | |
OKUZSDKSFUEYGG
|
7.2 | Ki | 2 | — | |
NNVINYYJNCKGRA
|
7.2 | IC50 | 4 | — | |
OCPILGAGUGFNJE
|
7.2 | IC50 | 6 | Yes | |
QQXRXXYLRNDAPS
|
7.2 | Ki | 2 | — | |
SQVAWPTVROSMDK
|
7.2 | IC50 | 2 | — | |
FOPORVBLOTVXEK
|
7.2 | Ki | 5 | — | |
LRHWSAFUUBKSML
|
7.2 | Ki | 5 | — | |
XXIWRTOLXWAEJC
|
7.2 | IC50 | 13 | Yes | |
XXJXHXJWQSCNPX
|
7.2 | IC50 | 7 | — | |
TUBBFDZWFNUZLH
|
7.2 | IC50 | 12 | Yes | |
IVGCXWIFBNPPBW
|
7.2 | IC50 | 6 | — | |
NRUVICOXXLOXCB
|
7.2 | IC50 | 13 | Yes | |
NXSJMRCTGYTSTK
|
7.2 | Kd | 200 | — | |
SSMSJTVEHMWTFZ
|
7.2 | IC50 | 6 | — | |
SSMSJTVEHMWTFZ
|
7.2 | IC50 | 6 | — | |
MGMNDPRNDCWSMZ
|
7.2 | IC50 | 12 | Yes | |
KOVNFJBXMBASSU
|
7.1 | IC50 | 4 | — | |
XTLUDGUIOTYGQW
|
7.1 | Ki | 2 | — | |
BPRHUHLTGPELTP
|
7.1 | IC50 | 2 | — | |
GRENHRYHWHSBLM
|
7.1 | IC50 | 12 | Yes | |
HXWARSZQGAFXJM
|
7.1 | Ki | 7 | — | |
KGPGFQWBCSZGEL
|
7.1 | IC50 | 59 | Yes | |
VJVSHXVHOJVSOB
|
7.1 | IC50 | 3 | — | |
LGCKGDRUTNACTA
|
7.1 | IC50 | 11 | — | |
OFPFIAWWDTYSBZ
|
7.1 | Ki | 15 | Yes | |
RHLRPKGACJKWPF
|
7.1 | IC50 | 12 | Yes | |
GGQAEINRBKFRGZ
|
7.1 | IC50 | 15 | Yes | |
PQWWKDOKHDWZBH
|
7.1 | IC50 | 6 | — | |
NHDDTLMPCVOXFH
|
7.1 | IC50 | 16 | Yes | |
DVXSJBDRMIDVMC
|
7.1 | IC50 | 3 | — | |
LMIPLKOPDQGFNB
|
7.1 | IC50 | 4 | — | |
QGXMVFJEJZPAES
|
7.1 | Ki | 2 | — | |
ADVDNJCNXOTAHZ
|
7.1 | IC50 | 2 | — | |
IGFXNXIRVKBKLL
|
7.1 | IC50 | 2 | — | |
KRXPQEKAJKYQGS
|
7.1 | Ki | 5 | — | |
LUDKZCXHZJRUAZ
|
7.1 | Ki | 5 | — | |
UWDSNDOLVCLEJW
|
7.1 | Ki | 8 | Yes | |
WQEXBJWFPAMSGJ
|
7.0 | Ki | 8 | Yes | |
USEYXZSHZLLAJS
|
7.0 | IC50 | 6 | — | |
IYPFXBNRYNDIDC
|
7.0 | IC50 | 2 | — | |
SXDPQGRNHSLZPC
|
7.0 | IC50 | 18 | — | |
KSITVHDHIJKJBG
|
7.0 | IC50 | 3 | — | |
KSITVHDHIJKJBG
|
7.0 | IC50 | 6 | — | |
MQCCJEYZKWZQHU
|
7.0 | IC50 | 15 | Yes | |
YSVVBGPTTSJYPA
|
7.0 | IC50 | 13 | Yes | |
PFAZIMNYEBJHOA
|
7.0 | IC50 | 12 | Yes | |
XRFOMFNAMTYCFF
|
7.0 | IC50 | 12 | Yes |