Target Details
| UniProt AC | P05771 |
|---|---|
| Gene Symbol | PRKCB |
| Protein Name | Protein kinase C beta type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 457
- Clinical molecules 133
- Avg pChEMBL 7.4
KEGG Pathways (73)
- AGE-RAGE signaling pathway in diabetic complications
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- B cell receptor signaling pathway
- Calcium signaling pathway
- Carbohydrate digestion and absorption
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin resistance
- Insulin secretion
- Leishmaniasis
- Leukocyte transendothelial migration
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- NF-kappa B signaling pathway
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Wnt signaling pathway
- mTOR signaling pathway
Active Molecules (457)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WTXAWDOYPWWUJL
|
10.1 | IC50 | 11 | — | |
SSXCVTWCXHGTLK
|
9.9 | IC50 | 11 | — | |
KTGVSZYYHHRRGW
|
9.8 | IC50 | 11 | — | |
VIESIZQAHOPEBR
|
9.8 | IC50 | 11 | — | |
CEOVOUHGBMXHLJ
|
9.8 | Ki | 2 | — | |
NVYBXIDWOJVGQI
|
9.8 | IC50 | 11 | — | |
REAZZDPREXHWNV
|
9.8 | Ki | 7 | — | |
APVOCXHEVZBCGS
|
9.7 | IC50 | 11 | — | |
DPRFHIQZBTUOOM
|
9.7 | Ki | 2 | — | |
BQJRUJTZSGYBEZ
|
9.7 | Kd | 4 | — | |
FANQQVWXAKUWNI
|
9.7 | IC50 | 6 | — | |
DHTLXMRCLSUJPP
|
9.7 | IC50 | 11 | — | |
FCYKUTUWVZTVAK
|
9.5 | Kd | 4 | — | |
VVRRZOFLLJAMIK
|
9.4 | IC50 | 11 | — | |
HPQAVQJTTFEWSN
|
9.4 | Ki | 2 | — | |
SUQYTYOVPXAUGB
|
9.4 | Ki | 5 | — | |
MJQUEDHRCUIRLF
|
9.4 | Kd | 4 | — | |
RHJPBGWFGOAEID
|
9.3 | Ki | 8 | Yes | |
QZVQSVZEEJEZSI
|
9.3 | Kd | 5 | — | |
WAKGEHXTOOFEAE
|
9.2 | IC50 | 27 | — | |
VRRYDMZFZWURRY
|
9.2 | Ki | 2 | — | |
HODOOWOVFQSXBB
|
9.2 | IC50 | 6 | — | |
YKEMNGJUZQIQPN
|
9.0 | Ki | 2 | — | |
XZCSQNOUJUIWEB
|
9.0 | Ki | 2 | — | |
UZCZCOMLMMSRLY
|
8.9 | IC50 | 6 | — | |
BQJRUJTZSGYBEZ
|
8.9 | Kd | 13 | Yes | |
GDZULWKNFKCRJP
|
8.9 | IC50 | 7 | — | |
URLJNGHIJZMXTK
|
8.8 | IC50 | 6 | — | |
ZMHXVAQNZDUNOG
|
8.8 | IC50 | 6 | — | |
XSJFPSCYMJFDNI
|
8.8 | Ki | 7 | — | |
INVLFTRLOIZJTP
|
8.8 | Ki | 2 | — | |
LKQQDFRBWPNRJF
|
8.8 | Ki | 2 | — | |
NVSJOASGKCGXBZ
|
8.8 | IC50 | 16 | Yes | |
IDSZLHFEKAUIOL
|
8.7 | IC50 | 7 | Yes | |
PHEDXBVPIONUQT
|
8.7 | Ki | 6 | Yes | |
COCXXLGXRJTCQZ
|
8.7 | IC50 | 6 | — | |
KMFOKKGKNMQAAN
|
8.7 | IC50 | 6 | — | |
OAVGBZOFDPFGPJ
|
8.7 | IC50 | 42 | Yes | |
QYBVZIIWBRIXMX
|
8.7 | IC50 | 12 | Yes | |
ZDFZJOAXAPUMLZ
|
8.7 | IC50 | 3 | — | |
PVJVEBBWSBNEJJ
|
8.7 | Ki | 2 | — | |
CVCIQKJLZNEUAZ
|
8.7 | IC50 | 7 | Yes | |
LFBIVGMGSSDSAY
|
8.7 | Ki | 2 | — | |
JZLFYMHIISZQCZ
|
8.7 | IC50 | 12 | Yes | |
AILQOERCUFVJMB
|
8.6 | Ki | 2 | — | |
QZCYXWFWSDBJGL
|
8.6 | Ki | 8 | Yes | |
DOIUTSAXPOMBSB
|
8.6 | Ki | 2 | — | |
FCVHMDURXUOCFY
|
8.6 | IC50 | 6 | — | |
FCVHMDURXUOCFY
|
8.6 | IC50 | 7 | — | |
HOWICUYRWBCICG
|
8.5 | IC50 | 6 | — |