Target Details
| UniProt AC | P05412 |
|---|---|
| Gene Symbol | JUN |
| Protein Name | Transcription factor Jun |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00170 (bZIP_1) PF03957 (Jun) |
Summary
- Multi-target molecules 69
- Clinical molecules 11
- Avg pChEMBL 6.68
KEGG Pathways (56)
- AGE-RAGE signaling pathway in diabetic complications
- Amphetamine addiction
- Apoptosis
- B cell receptor signaling pathway
- Breast cancer
- C-type lectin receptor signaling pathway
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cocaine addiction
- Colorectal cancer
- Coronavirus disease - COVID-19
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- GnRH signaling pathway
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- Inflammatory bowel disease
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pertussis
- Relaxin signaling pathway
- Renal cell carcinoma
- Rheumatoid arthritis
- Salmonella infection
- Shigellosis
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Viral carcinogenesis
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (69)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XYMYOQHYWDKQLT
|
6.2 | IC50 | 4 | — | |
PYFMPAWBPVAOQN
|
6.2 | IC50 | 2 | — | |
FUDMBWNGRHHUHL
|
6.2 | IC50 | 2 | — | |
BFUXXUCYXDKBGL
|
6.2 | IC50 | 5 | — | |
DSYPQICAGKUAFT
|
6.2 | IC50 | 5 | — | |
XOHKOCNFVBVEEY
|
6.2 | IC50 | 5 | — | |
ARMFMDYRYOKSOW
|
6.2 | IC50 | 5 | Yes | |
HYNZVOLLNHBFQJ
|
6.1 | IC50 | 4 | Yes | |
RHBTWDFORLRVLM
|
6.1 | IC50 | 4 | — | |
KXNZPASCSDMHFQ
|
6.1 | IC50 | 5 | Yes | |
XQLINAVACFUFEH
|
6.1 | IC50 | 4 | Yes | |
JHPYMNZPMYYRPA
|
6.1 | IC50 | 4 | — | |
QRVJINBBPOWTHS
|
6.0 | IC50 | 5 | — | |
GGSIOFMZSJTMMB
|
6.0 | IC50 | 2 | — | |
JWIIKHRJOUQCQG
|
6.0 | IC50 | 5 | — | |
KBGATAWDHCZFQR
|
6.0 | IC50 | 5 | — | |
MMSKFTCJMPJSON
|
6.0 | IC50 | 5 | — | |
YHCPTBQDJKEVNL
|
6.0 | IC50 | 5 | — | |
YZVLYVMNCAIILW
|
6.0 | IC50 | 5 | — |