Target Details
| UniProt AC | P05231 |
|---|---|
| Gene Symbol | IL6 |
| Protein Name | Interleukin-6 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00489 (IL6) |
Summary
- Multi-target molecules 17
- Clinical molecules 0
- Avg pChEMBL 8.04
KEGG Pathways (51)
- AGE-RAGE signaling pathway in diabetic complications
- African trypanosomiasis
- Alcoholic liver disease
- Alzheimer disease
- Amoebiasis
- Antifolate resistance
- C-type lectin receptor signaling pathway
- Cellular senescence
- Chagas disease
- Coronavirus disease - COVID-19
- Cytokine-cytokine receptor interaction
- Cytosolic DNA-sensing pathway
- EGFR tyrosine kinase inhibitor resistance
- Epstein-Barr virus infection
- FoxO signaling pathway
- Graft-versus-host disease
- HIF-1 signaling pathway
- Hematopoietic cell lineage
- Hepatitis B
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Hypertrophic cardiomyopathy
- IL-17 signaling pathway
- Inflammatory bowel disease
- Influenza A
- Insulin resistance
- Intestinal immune network for IgA production
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Legionellosis
- Lipid and atherosclerosis
- Malaria
- Measles
- NOD-like receptor signaling pathway
- Non-alcoholic fatty liver disease
- PI3K-Akt signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Rheumatoid arthritis
- Salmonella infection
- TNF signaling pathway
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Transcriptional misregulation in cancer
- Tuberculosis
- Viral protein interaction with cytokine and cytokine receptor
- Yersinia infection
Associated Diseases (5)
Active Molecules (17)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MLZLXEBPLLEJSK
|
9.0 | IC50 | 2 | — | |
ZITUOTORLGBDOZ
|
9.0 | IC50 | 2 | — | |
PFBJOLPYJDUPPW
|
8.9 | IC50 | 2 | — | |
ORSBFWQUUWUENG
|
8.7 | IC50 | 2 | — | |
UHIXENGVNOWISA
|
8.6 | IC50 | 2 | — | |
IXZOHGPZAQLIBH
|
8.4 | IC50 | 8 | — | |
VLRUOHNPKMZQHN
|
8.4 | IC50 | 2 | — | |
OIGNJSKKLXVSLS
|
8.4 | IC50 | 7 | — | |
RCRRMTBHOFTNFS
|
8.4 | IC50 | 2 | — | |
IBEIVQBULJKLFB
|
8.2 | IC50 | 2 | — | |
IXZOHGPZAQLIBH
|
8.0 | IC50 | 6 | — | |
AUIFRJWXYUNPPV
|
7.6 | IC50 | 2 | — | |
UVSMNLNDYGZFPF
|
7.2 | IC50 | 7 | — | |
BVXLAHSJXXSWFF
|
7.2 | IC50 | 2 | — | |
RSNPAKAFCAAMBH
|
7.2 | IC50 | 8 | — | |
IXZOHGPZAQLIBH
|
7.1 | IC50 | 6 | — | |
XNVXVNJRQLVPBF
|
6.5 | IC50 | 2 | — |