Target Details
| UniProt AC | P05129 |
|---|---|
| Gene Symbol | PRKCG |
| Protein Name | Protein kinase C gamma type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00168 (C2) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 311
- Clinical molecules 119
- Avg pChEMBL 7.06
KEGG Pathways (64)
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- Amphetamine addiction
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor-regulated calcium reabsorption
- ErbB signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Leukocyte transendothelial migration
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- Natural killer cell mediated cytotoxicity
- Neuroactive ligand signaling
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Wnt signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (311)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WTXAWDOYPWWUJL
|
10.1 | IC50 | 11 | — | |
SSXCVTWCXHGTLK
|
9.9 | IC50 | 11 | — | |
KTGVSZYYHHRRGW
|
9.8 | IC50 | 11 | — | |
VIESIZQAHOPEBR
|
9.8 | IC50 | 11 | — | |
NVYBXIDWOJVGQI
|
9.8 | IC50 | 11 | — | |
APVOCXHEVZBCGS
|
9.7 | IC50 | 11 | — | |
DHTLXMRCLSUJPP
|
9.7 | IC50 | 11 | — | |
VVRRZOFLLJAMIK
|
9.4 | IC50 | 11 | — | |
REAZZDPREXHWNV
|
9.4 | Ki | 7 | — | |
QZVQSVZEEJEZSI
|
9.3 | Kd | 5 | — | |
RHJPBGWFGOAEID
|
9.2 | Ki | 8 | Yes | |
XSJFPSCYMJFDNI
|
9.2 | Ki | 7 | — | |
SUQYTYOVPXAUGB
|
8.9 | Ki | 5 | — | |
BQJRUJTZSGYBEZ
|
8.8 | Kd | 13 | Yes | |
NVSJOASGKCGXBZ
|
8.8 | IC50 | 16 | Yes | |
QYBVZIIWBRIXMX
|
8.7 | IC50 | 12 | Yes | |
JZLFYMHIISZQCZ
|
8.7 | IC50 | 12 | Yes | |
HKSZLNNOFSGOKW
|
8.5 | Ki | 118 | — | |
QZCYXWFWSDBJGL
|
8.5 | Ki | 8 | Yes | |
PHEDXBVPIONUQT
|
8.3 | Ki | 6 | Yes | |
BPNNZZBLGSVSAA
|
8.3 | IC50 | 6 | — | |
BPNNZZBLGSVSAA
|
8.3 | IC50 | 7 | — | |
CKJRKRPDNLRZPQ
|
8.3 | IC50 | 6 | — | |
CKJRKRPDNLRZPQ
|
8.3 | IC50 | 7 | — | |
FCVHMDURXUOCFY
|
8.3 | IC50 | 6 | — | |
FCVHMDURXUOCFY
|
8.3 | IC50 | 7 | — | |
SWKUTOXEFLDOID
|
8.3 | Ki | 7 | — | |
NJPWCTYVEJIQBM
|
8.2 | Ki | 72 | — | |
SAYMBMAHSBYKKR
|
8.2 | IC50 | 12 | Yes | |
HKSZLNNOFSGOKW
|
8.2 | IC50 | 408 | — | |
YWTBGJGMTBHQTM
|
8.1 | Ki | 65 | — | |
POTTVLREWUNNRO
|
8.1 | IC50 | 17 | Yes | |
CKCJAVJYEBDBEI
|
8.0 | Ki | 5 | — | |
PGBOLFMQGRFIRL
|
8.0 | Ki | 5 | — | |
BPNNZZBLGSVSAA
|
8.0 | IC50 | 6 | — | |
BPNNZZBLGSVSAA
|
8.0 | IC50 | 7 | — | |
CDXNZQYZADSNCP
|
8.0 | IC50 | 12 | Yes | |
DSXXEELGXBCYNQ
|
8.0 | IC50 | 28 | Yes | |
FFKRSNGYONHGEV
|
8.0 | IC50 | 12 | Yes | |
IRGJDPZJEUYSKS
|
8.0 | IC50 | 7 | — | |
IRGJDPZJEUYSKS
|
8.0 | IC50 | 9 | — | |
IRGJDPZJEUYSKS
|
8.0 | IC50 | 9 | — | |
IRGJDPZJEUYSKS
|
8.0 | IC50 | 6 | — | |
OPQUGNXQOSDRMT
|
8.0 | IC50 | 12 | Yes | |
PGWBJRRPIUVOAD
|
8.0 | IC50 | 12 | Yes | |
LPMWTDXPUOFZOV
|
7.9 | Ki | 7 | — | |
YIZRPXUMLQCIMQ
|
7.9 | IC50 | 9 | — | |
YIZRPXUMLQCIMQ
|
7.9 | IC50 | 6 | — | |
PBCZSGKMGDDXIJ
|
7.9 | IC50 | 14 | Yes | |
YIZRPXUMLQCIMQ
|
7.9 | IC50 | 7 | — |