Target Details
| UniProt AC | P04637 |
|---|---|
| Gene Symbol | TP53 |
| Protein Name | Cellular tumor antigen p53 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00870 (P53) PF08563 (P53_TAD) PF07710 (P53_tetramer) PF18521 (TAD2) |
Summary
- Multi-target molecules 1,173
- Clinical molecules 0
- Avg pChEMBL 8.01
KEGG Pathways (51)
- Amyotrophic lateral sclerosis
- Apoptosis
- Basal cell carcinoma
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Central carbon metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- Ferroptosis
- Fluid shear stress and atherosclerosis
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Huntington disease
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Longevity regulating pathway
- MAPK signaling pathway
- Measles
- Melanoma
- MicroRNAs in cancer
- Mitophagy - animal
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parkinson disease
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Shigellosis
- Small cell lung cancer
- Sphingolipid signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Transcriptional misregulation in cancer
- Viral carcinogenesis
- Wnt signaling pathway
- p53 signaling pathway
Associated Diseases (48)
- Adrenal carcinoma
- Adult T-cell leukemia
- Basal cell carcinoma
- Bladder cancer
- Bone marrow failure syndrome
- Breast cancer
- Burkitt lymphoma
- Cancer of the anal canal
- Cholangiocarcinoma
- Choriocarcinoma
- Choroid plexus papilloma
- Chronic lymphocytic leukemia
- Chronic myeloid leukemia
- Chronic myelomonocytic leukemia
- Colorectal cancer
- Diffuse large B-cell lymphoma, not otherwise specified
- Endometrial cancer
- Esophageal cancer
- Fallopian tube cancer
- Gallbladder cancer
- Gastric cancer
- Giant cell tumor of bone
- Glioma
- Hairy cell leukemia
- Hepatic angiosarcoma
- Hepatocellular carcinoma
- Kaposi sarcoma
- Laryngeal cancer
- Li-Fraumeni syndrome
- Malignant pleural mesothelioma
- Mantle cell lymphoma
- Medulloblastoma
- Melanoma
- Merkel cell carcinoma
- Multiple myeloma
- Mycosis fungoides
- Nephroblastoma
- Non-small cell lung cancer
- Oral cancer
- Oropharyngeal cancer
- Osteosarcoma
- Ovarian cancer
- Pancreatic cancer
- Penile cancer
- Small cell lung cancer
- Squamous cell carcinoma
- Thyroid cancer
- Vulvar cancer
Active Molecules (1,173)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NAOFRLUOVJQSJF
|
8.7 | IC50 | 2 | — | |
PHETUTHFDPFIRQ
|
8.7 | IC50 | 2 | — | |
PJVZSNYUBWTHII
|
8.7 | IC50 | 2 | — | |
QFSQODXTNHWKSL
|
8.7 | Ki | 2 | — | |
QSCRDUJWRZHKKS
|
8.7 | IC50 | 2 | — | |
QXTIAAQSOXPAAN
|
8.7 | IC50 | 2 | — | |
WJOQNXHUFMKXHU
|
8.7 | IC50 | 2 | — | |
VMAKRIBRIRXACI
|
8.7 | IC50 | 2 | — | |
BVRNRDKNHVCXOA
|
8.7 | IC50 | 2 | — | |
NAMQEWAUDBCILZ
|
8.7 | IC50 | 2 | — | |
RXUWUIRMPWZSAR
|
8.7 | IC50 | 2 | — | |
WDEVSGDQMMXJMI
|
8.7 | IC50 | 2 | — | |
BMYHCCBUUIQXSX
|
8.7 | IC50 | 2 | — | |
DHUGCWNOAWLBFL
|
8.7 | IC50 | 2 | — | |
IJESPKAZVNRIFC
|
8.7 | IC50 | 2 | — | |
IYUAVSWLCYUDDB
|
8.7 | IC50 | 2 | — | |
LPDZTJPCRROKAL
|
8.7 | IC50 | 2 | — | |
LYZBKNYTGQNBNY
|
8.7 | IC50 | 2 | — | |
MNPCPZFFXZLCLX
|
8.7 | IC50 | 2 | — | |
NKCCNDXCKALGSS
|
8.7 | IC50 | 2 | — | |
NORYKJFEQYUVKB
|
8.7 | IC50 | 2 | — | |
NQBLVFSQNANGBM
|
8.7 | IC50 | 2 | — | |
NTPHWEOQINJKPH
|
8.7 | IC50 | 2 | — | |
OBGWWKKHXPKFIP
|
8.7 | IC50 | 2 | — | |
PMXGSEVMEXTCLI
|
8.7 | IC50 | 2 | — | |
QCZBNRNLGNLUDF
|
8.7 | IC50 | 2 | — | |
QGKMXIKHMXVVSS
|
8.7 | IC50 | 2 | — | |
QVTGOELDGKBBJC
|
8.7 | IC50 | 2 | — | |
UTMAJFUNDVHBFE
|
8.7 | IC50 | 2 | — | |
VLFJDZPABFINSO
|
8.7 | IC50 | 2 | — | |
XLEZQFNDJNRAQL
|
8.7 | IC50 | 2 | — | |
XPPOSVDBYKUPEU
|
8.7 | IC50 | 2 | — | |
HONPZSDBHRBCAL
|
8.7 | IC50 | 2 | — | |
HVEKUPRTCOLYET
|
8.7 | IC50 | 2 | — | |
ZMOJZMJYTFNKSG
|
8.7 | IC50 | 2 | — | |
UZPANWLGEIIIFW
|
8.6 | IC50 | 2 | — | |
ACKYWAVUACZTMI
|
8.6 | IC50 | 2 | — | |
IHUOGFBGYUGFNV
|
8.6 | IC50 | 2 | — | |
FXHJGJMHGMOXPI
|
8.6 | IC50 | 2 | — | |
UFSIBXMTOQLCGE
|
8.6 | Ki | 3 | — | |
AYGHMHFKSMKVAK
|
8.6 | IC50 | 2 | — | |
IARKWVZHJYWTDX
|
8.6 | IC50 | 2 | — | |
VZDNISKFMYZWGF
|
8.6 | IC50 | 2 | — | |
CHQPSERGPFMVBZ
|
8.6 | IC50 | 2 | — | |
NNVXEGMVOBLWBC
|
8.6 | IC50 | 2 | — | |
QIDDUFPDNUMICE
|
8.6 | IC50 | 2 | — | |
VXJACAQXCDSPJE
|
8.6 | IC50 | 2 | — | |
KGWSSRVAXMWCPO
|
8.6 | Ki | 2 | — | |
XALXILVSCADHCC
|
8.6 | Ki | 2 | — | |
ZDERXPIAFXXKIC
|
8.6 | IC50 | 2 | — |