Target Details
| UniProt AC | P04637 |
|---|---|
| Gene Symbol | TP53 |
| Protein Name | Cellular tumor antigen p53 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00870 (P53) PF08563 (P53_TAD) PF07710 (P53_tetramer) PF18521 (TAD2) |
Summary
- Multi-target molecules 1,173
- Clinical molecules 0
- Avg pChEMBL 8.01
KEGG Pathways (51)
- Amyotrophic lateral sclerosis
- Apoptosis
- Basal cell carcinoma
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Central carbon metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- Ferroptosis
- Fluid shear stress and atherosclerosis
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Huntington disease
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Longevity regulating pathway
- MAPK signaling pathway
- Measles
- Melanoma
- MicroRNAs in cancer
- Mitophagy - animal
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parkinson disease
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Shigellosis
- Small cell lung cancer
- Sphingolipid signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Transcriptional misregulation in cancer
- Viral carcinogenesis
- Wnt signaling pathway
- p53 signaling pathway
Associated Diseases (48)
- Adrenal carcinoma
- Adult T-cell leukemia
- Basal cell carcinoma
- Bladder cancer
- Bone marrow failure syndrome
- Breast cancer
- Burkitt lymphoma
- Cancer of the anal canal
- Cholangiocarcinoma
- Choriocarcinoma
- Choroid plexus papilloma
- Chronic lymphocytic leukemia
- Chronic myeloid leukemia
- Chronic myelomonocytic leukemia
- Colorectal cancer
- Diffuse large B-cell lymphoma, not otherwise specified
- Endometrial cancer
- Esophageal cancer
- Fallopian tube cancer
- Gallbladder cancer
- Gastric cancer
- Giant cell tumor of bone
- Glioma
- Hairy cell leukemia
- Hepatic angiosarcoma
- Hepatocellular carcinoma
- Kaposi sarcoma
- Laryngeal cancer
- Li-Fraumeni syndrome
- Malignant pleural mesothelioma
- Mantle cell lymphoma
- Medulloblastoma
- Melanoma
- Merkel cell carcinoma
- Multiple myeloma
- Mycosis fungoides
- Nephroblastoma
- Non-small cell lung cancer
- Oral cancer
- Oropharyngeal cancer
- Osteosarcoma
- Ovarian cancer
- Pancreatic cancer
- Penile cancer
- Small cell lung cancer
- Squamous cell carcinoma
- Thyroid cancer
- Vulvar cancer
Active Molecules (1,173)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MYSLCGGRVCUZKN
|
9.5 | IC50 | 2 | — | |
NAKBBRHGPJQAJG
|
9.5 | IC50 | 2 | — | |
NYMRMAMSVZGJIB
|
9.5 | IC50 | 2 | — | |
OGIAYNRPXYLIQE
|
9.5 | IC50 | 2 | — | |
OVWIUVUGTIFJJB
|
9.5 | IC50 | 2 | — | |
PHSXCIHKZKDKHQ
|
9.5 | IC50 | 2 | — | |
PYYYIHIPDRYKPU
|
9.5 | IC50 | 2 | — | |
RWUPMJSITUMDJR
|
9.5 | IC50 | 2 | — | |
RZGSVRMDUXKDNU
|
9.5 | IC50 | 2 | — | |
WOEXCIRNQPQVLZ
|
9.5 | IC50 | 2 | — | |
WQIOEZAVYUNRRD
|
9.5 | IC50 | 2 | — | |
XNDNLVMSNNGZHE
|
9.5 | IC50 | 2 | — | |
XQBLZSNCUVVCBF
|
9.5 | IC50 | 2 | — | |
ZZKNRHXOWVNNEF
|
9.5 | IC50 | 2 | — | |
BGPLNPYJPVUTME
|
9.5 | IC50 | 2 | — | |
CQNLQGGJXSRPQH
|
9.5 | IC50 | 2 | — | |
ZKXXUOFBGYBXBG
|
9.5 | IC50 | 2 | — | |
AKWZPUSKVCENQN
|
9.5 | IC50 | 2 | — | |
KEWDJHXGSOLCJT
|
9.5 | IC50 | 2 | — | |
JVQOZXAGUFLHTP
|
9.5 | IC50 | 2 | — | |
YYGAPUHEYRIFSS
|
9.5 | IC50 | 2 | — | |
YYOBZKJTJKLZNG
|
9.5 | IC50 | 2 | — | |
KCTRKWJYYSKEQI
|
9.5 | IC50 | 2 | — | |
QQLGWDCSGRNUFW
|
9.5 | IC50 | 2 | — | |
RNNIMJVUCFVPIR
|
9.5 | IC50 | 2 | — | |
YMDJIUXSNMFBNK
|
9.5 | IC50 | 2 | — | |
AUCFWTPOSQPMCN
|
9.5 | IC50 | 2 | — | |
PJGMHURMTNPVFZ
|
9.5 | IC50 | 2 | — | |
RNNIMJVUCFVPIR
|
9.5 | IC50 | 2 | — | |
HHNKSOUSJFWEBC
|
9.4 | IC50 | 2 | — | |
IBBCADJDJYCEKF
|
9.4 | IC50 | 2 | — | |
FGPTWTSRUGMJDE
|
9.4 | IC50 | 2 | — | |
HHNKSOUSJFWEBC
|
9.4 | IC50 | 2 | — | |
MBCRUKORVFBRLW
|
9.4 | IC50 | 2 | — | |
RWYNHMVMXJDBQA
|
9.4 | IC50 | 2 | — | |
CVUUVHAYWBQSNU
|
9.4 | IC50 | 2 | — | |
FKLVAGWTFKZMIT
|
9.4 | IC50 | 2 | — | |
ROQOHOOZYYGUFU
|
9.4 | IC50 | 2 | — | |
DZVVZBDVIPZGIS
|
9.4 | IC50 | 2 | — | |
JMBUUJKRFGVBCW
|
9.4 | IC50 | 2 | — | |
KWIUQJKKCSQXRV
|
9.4 | IC50 | 2 | — | |
LTUHSZJIRQEHAV
|
9.4 | IC50 | 2 | — | |
MABNPXAXACEAMW
|
9.4 | IC50 | 2 | — | |
MSRKSLFBICFCIN
|
9.4 | IC50 | 2 | — | |
NDUDWHAEZHCIRY
|
9.4 | IC50 | 2 | — | |
SFRDODZOVCBNRD
|
9.4 | IC50 | 2 | — | |
SGPRGPKOFWSIJK
|
9.4 | Ki | 2 | — | |
SSZVBEVGRVJGSK
|
9.4 | IC50 | 2 | — | |
AMVOKCMSEMEARJ
|
9.4 | IC50 | 2 | — | |
SOSFGAIKFDNWDG
|
9.4 | IC50 | 2 | — |