Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JWNPDZNEKVCWMY
|
8.1 | pIC50 | 57 | Yes | |
KMMXFFDNBCQBEI
|
8.1 | IC50 | 3 | Yes | |
PTPHYGJNVDJTAD
|
8.1 | IC50 | 2 | — | |
RVCKMZIQUFKZFD
|
8.1 | IC50 | 7 | — | |
SYCYMWZFELUOFO
|
8.1 | IC50 | 2 | — | |
YFFQYUIFTHZMHX
|
8.1 | IC50 | 2 | — | |
DKOJJTJTHLDNCA
|
8.1 | IC50 | 2 | — | |
NAGWASHXBLASPZ
|
8.1 | IC50 | 2 | — | |
NAGWASHXBLASPZ
|
8.1 | IC50 | 2 | — | |
OXAZPVDJCIJPFP
|
8.1 | IC50 | 4 | — | |
QWDWJDWSZMBTOA
|
8.1 | IC50 | 2 | — | |
SDAXRPZVCMFHRU
|
8.1 | IC50 | 2 | — | |
ZYVUNNQGVXTJSW
|
8.1 | IC50 | 4 | — | |
OAMVGUFHZPRXOM
|
8.1 | IC50 | 2 | — | |
VGJRVAUEDBYNMP
|
8.1 | IC50 | 2 | — | |
VPRLBIZASKQOSZ
|
8.1 | IC50 | 2 | — | |
ANOJHRBABLZKIY
|
8.1 | IC50 | 2 | — | |
FGPPXNCHKYRZCI
|
8.1 | IC50 | 6 | — | |
IBUAKKIEDFKTKJ
|
8.1 | IC50 | 3 | Yes | |
VBYCLUNCQJLFHE
|
8.1 | pIC50 | 4 | Yes | |
AJJOCYLKITUOSA
|
8.1 | pIC50 | 2 | Yes | |
AKGBHBRPZOEXLG
|
8.1 | IC50 | 2 | — | |
IKVDAZUYVVSZPS
|
8.1 | pIC50 | 2 | Yes | |
JPKXJWBKGYESKN
|
8.1 | IC50 | 2 | — | |
KJDFHCUXSFQUTK
|
8.1 | IC50 | 2 | — | |
KYZBBCJEGMZWLG
|
8.1 | IC50 | 2 | — | |
NHXPKHTXOWBCBM
|
8.1 | pIC50 | 2 | Yes | |
PBIJKZCHYCDPPC
|
8.1 | pIC50 | 2 | Yes | |
STYZRTBSWIVUKT
|
8.1 | IC50 | 2 | — | |
VKFHLVGNIPONMR
|
8.1 | pIC50 | 2 | Yes | |
WLLHJVRLVANDFW
|
8.1 | IC50 | 2 | — | |
WLLHJVRLVANDFW
|
8.1 | IC50 | 2 | — | |
BLWDOLCMBQDSMT
|
8.0 | IC50 | 4 | — | |
FAYNMSGELVYJGD
|
8.0 | IC50 | 2 | — | |
IKXRBNYJGLGKNN
|
8.0 | IC50 | 2 | — | |
OYAHQWRTIPQZIR
|
8.0 | pIC50 | 13 | Yes | |
LCYSSHSIKSARGO
|
8.0 | IC50 | 19 | — | |
QUJLAHZCPHZTBT
|
8.0 | IC50 | 2 | — | |
QZMGOBDHHJBODW
|
8.0 | IC50 | 4 | — | |
UCSIYDCODBRGKW
|
8.0 | pIC50 | 13 | Yes | |
WBMZMVJATQKBRA
|
8.0 | IC50 | 2 | — | |
WICGSIZULNDHDO
|
8.0 | IC50 | 2 | — | |
XWHJPZMQYNMSOJ
|
8.0 | IC50 | 4 | — | |
XYFPWWZEPKGCCK
|
8.0 | IC50 | 34 | — | |
CRKDDCRCAGBCAI
|
8.0 | IC50 | 2 | — | |
HKRUJGXEWHNKCW
|
8.0 | IC50 | 2 | — | |
JBSDBYXRHGAOIT
|
8.0 | IC50 | 2 | — | |
NYHCGCDSBXKURV
|
8.0 | IC50 | 2 | — | |
QIMXUZNKIMFXLS
|
8.0 | IC50 | 2 | — | |
SXBQBMPZTKSXKA
|
8.0 | Ki | 2 | — |