Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CDTPSPBCPAHLJJ
|
8.2 | IC50 | 2 | — | |
DJAMFWBXWBHEQD
|
8.2 | IC50 | 2 | — | |
FNYHTKUCTLSINN
|
8.2 | pIC50 | 3 | Yes | |
JBGMOEFHUIKRFN
|
8.2 | IC50 | 3 | — | |
JGSKJUYVTDKFKT
|
8.2 | IC50 | 3 | — | |
RKUHGVDFHLNNLT
|
8.2 | IC50 | 2 | — | |
RRXSXSCXMPQLTP
|
8.2 | pIC50 | 2 | Yes | |
SMOPKEHQPPXRSH
|
8.2 | IC50 | 8 | — | |
SOCMOTGNRXRMOH
|
8.2 | pIC50 | 13 | Yes | |
UWUFUUGZSOQBCY
|
8.2 | pIC50 | 2 | Yes | |
WGERYIXXYKWSML
|
8.2 | IC50 | 2 | — | |
XJMBQSMRJLKLBY
|
8.2 | IC50 | 2 | — | |
XRZUOLFZBNANGA
|
8.2 | pIC50 | 2 | Yes | |
YHCWZWFXNSGDTJ
|
8.2 | IC50 | 2 | — | |
ZAFWWWJOUAFSJP
|
8.2 | pIC50 | 2 | Yes | |
ZOGNMJNQBLFBPT
|
8.2 | pIC50 | 2 | Yes | |
BQKAPRHCWWQTIM
|
8.1 | IC50 | 2 | — | |
BULITYBNVIHSDM
|
8.1 | IC50 | 2 | — | |
CMZKQVFPFYPHOD
|
8.1 | IC50 | 3 | — | |
JXQKQNNMNCWTIW
|
8.1 | IC50 | 2 | — | |
PDNKMRBXZXHUFT
|
8.1 | IC50 | 4 | Yes | |
SFSNVFCNLQLQLX
|
8.1 | IC50 | 4 | — | |
UUFDRURWKKKAJF
|
8.1 | pIC50 | 4 | Yes | |
PXBGUQFPFOVMDS
|
8.1 | Ki | 2 | — | |
DLQXAWIVHRHOQT
|
8.1 | pIC50 | 6 | Yes | |
DSBPVMDUESDKNK
|
8.1 | pIC50 | 9 | Yes | |
MGOJOGOPSJFRER
|
8.1 | IC50 | 2 | — | |
SDAXRPZVCMFHRU
|
8.1 | IC50 | 2 | — | |
ABLXXKUDDSMAHU
|
8.1 | IC50 | 4 | — | |
GRAAVPHBSRABFO
|
8.1 | pIC50 | 2 | Yes | |
OTIXNYWEVTWQKC
|
8.1 | IC50 | 2 | — | |
UXFMBILQHOZKAC
|
8.1 | IC50 | 2 | — | |
YLJFSGHVBXORPD
|
8.1 | IC50 | 2 | — | |
CAZQZPUZMIOJCR
|
8.1 | pIC50 | 2 | Yes | |
FIENMRUUADTWJC
|
8.1 | pIC50 | 2 | Yes | |
FMSVVUDMNOXYTG
|
8.1 | pIC50 | 2 | Yes | |
GFQMYECKUFYUSH
|
8.1 | IC50 | 2 | — | |
JIJDVLXBQGQRQM
|
8.1 | IC50 | 3 | — | |
JUKNHBAVDHQUJP
|
8.1 | pIC50 | 3 | Yes | |
KOQXIMMOAUHZFN
|
8.1 | pIC50 | 2 | Yes | |
LRPVMNFUGWCSFJ
|
8.1 | Ki | 2 | — | |
LYKORKBUGRQTBH
|
8.1 | pIC50 | 2 | Yes | |
OCTIIGKPLDEYJH
|
8.1 | IC50 | 2 | — | |
PQVBRHDKJDCOQV
|
8.1 | IC50 | 2 | — | |
QYNJVRUBTKSLBX
|
8.1 | IC50 | 4 | — | |
QYRNHUOFBYAKEW
|
8.1 | IC50 | 2 | — | |
RKUBYGFDHATQAZ
|
8.1 | IC50 | 4 | — | |
FKSFPUSFMMAXPK
|
8.1 | IC50 | 2 | — | |
GGLLZEGVMRMANJ
|
8.1 | pIC50 | 13 | Yes | |
JEQABWAFHZXXLZ
|
8.1 | IC50 | 4 | — |