Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XVNANJHJARJMEU
|
8.3 | IC50 | 2 | — | |
XVNANJHJARJMEU
|
8.3 | IC50 | 2 | — | |
GMXIFCSQVFGFBC
|
8.2 | IC50 | 3 | Yes | |
NSDAIDHIWWAWPP
|
8.2 | Ki | 2 | — | |
YDJAXPJDHWQNLF
|
8.2 | IC50 | 4 | Yes | |
ZBGGBRQHYYAQQU
|
8.2 | IC50 | 2 | — | |
LOFBARGGJCBDJT
|
8.2 | IC50 | 4 | — | |
NYYMSVYTUYTODA
|
8.2 | IC50 | 4 | — | |
WAZLQAVHYOQHHY
|
8.2 | IC50 | 2 | — | |
CGRLNCABNBKKKW
|
8.2 | IC50 | 4 | — | |
DNUXMLXSNBBBRZ
|
8.2 | IC50 | 2 | — | |
HWTNQKRGLLXUKG
|
8.2 | IC50 | 2 | — | |
JFAWJVBCLVAICC
|
8.2 | IC50 | 2 | — | |
KSGYKTRNRCPDHT
|
8.2 | IC50 | 2 | — | |
ORCJXEWMAFCVBL
|
8.2 | Ki | 2 | — | |
OTMPOVZNMVTURI
|
8.2 | pIC50 | 2 | Yes | |
ULXXDDBFHOBEHA
|
8.2 | pIC50 | 15 | Yes | |
VXPOFHMNNNIQLJ
|
8.2 | IC50 | 2 | — | |
YFQGFLOTVWXVMG
|
8.2 | IC50 | 2 | — | |
YJELZTGEMAQGHU
|
8.2 | IC50 | 2 | — | |
ZFRQPCBLXWLNAT
|
8.2 | IC50 | 2 | — | |
ZKRKJAPDCNQMCJ
|
8.2 | pIC50 | 2 | Yes | |
ZSCILBYYYABZHM
|
8.2 | IC50 | 2 | — | |
IWHGCJQTYUACSO
|
8.2 | IC50 | 2 | — | |
JDRIEMWAOXMCLE
|
8.2 | IC50 | 2 | — | |
QDNUPNWLDSDITR
|
8.2 | IC50 | 2 | — | |
WRUDTZAASVCWAT
|
8.2 | IC50 | 2 | — | |
BBYDGVLJODYSJL
|
8.2 | IC50 | 2 | — | |
BMBAFWOVSWBDSJ
|
8.2 | IC50 | 2 | — | |
UYWHKGJSHFOELO
|
8.2 | IC50 | 2 | — | |
XZFMZWHIYIWGAL
|
8.2 | IC50 | 2 | — | |
KJBZQIKLKWQVLL
|
8.2 | IC50 | 3 | — | |
OLURIASFBDWIAK
|
8.2 | pIC50 | 2 | Yes | |
UAXLMFNKXDVZKH
|
8.2 | IC50 | 3 | — | |
YSTSGFGNZVLCQE
|
8.2 | IC50 | 2 | — | |
DEBQVAUIPWIBMA
|
8.2 | pIC50 | 2 | Yes | |
FNDAEXWGUUPCOX
|
8.2 | pIC50 | 2 | Yes | |
JHZHWAOFJSCIEJ
|
8.2 | pIC50 | 2 | Yes | |
KVXCGOZCGKXYQZ
|
8.2 | IC50 | 2 | — | |
IOWFCZSAGHCMTJ
|
8.2 | IC50 | 2 | — | |
SABXXXTUFOTOBE
|
8.2 | IC50 | 2 | — | |
YHOXAOXMRAKRBS
|
8.2 | IC50 | 2 | — | |
APEBZRPPOOOJJN
|
8.2 | IC50 | 2 | — | |
BFRZHSWXTMOYRY
|
8.2 | IC50 | 2 | — | |
JWNAINYXINYHML
|
8.2 | IC50 | 3 | — | |
SDEAXTCZPQIFQM
|
8.2 | IC50 | 3 | — | |
WHZWIUHEEWZECR
|
8.2 | IC50 | 2 | — | |
AYNLVZLZOVZSHL
|
8.2 | IC50 | 3 | — | |
BKGAQRNSVMXWHB
|
8.2 | IC50 | 2 | — | |
BOPSHQJEVUOWPS
|
8.2 | Ki | 2 | — |