Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VHGQJLWYOGRRAE
|
8.4 | IC50 | 4 | — | |
AIDBOWZYMBFXFC
|
8.4 | IC50 | 2 | — | |
APJQHEXYMWQXSV
|
8.4 | IC50 | 2 | — | |
IBZAELMPACLLJJ
|
8.4 | IC50 | 2 | — | |
LYCJWVRLAGIQEB
|
8.4 | IC50 | 2 | — | |
PFMDDCHUGSRIJN
|
8.4 | IC50 | 4 | Yes | |
YBZNHFHVVZMUSP
|
8.4 | IC50 | 2 | — | |
PEOYVSCYYMEJBB
|
8.3 | pIC50 | 3 | Yes | |
RXIRGBATMPSFBO
|
8.3 | IC50 | 2 | — | |
HHAXMCRVXIYOJR
|
8.3 | IC50 | 4 | — | |
ITTRLTNMFYIYPA
|
8.3 | IC50 | 17 | — | |
JZSLVCXMHPNGNA
|
8.3 | IC50 | 5 | — | |
PCOFCPRYWPQQMW
|
8.3 | IC50 | 2 | — | |
UYSGXFWENHROKH
|
8.3 | IC50 | 2 | — | |
XFDYLGGJRSOHKI
|
8.3 | pIC50 | 13 | Yes | |
WFPUKTYKJNILHS
|
8.3 | IC50 | 2 | — | |
WYZOMYWEQQWFAG
|
8.3 | IC50 | 3 | Yes | |
LHMPUXRYZHNWOO
|
8.3 | IC50 | 2 | — | |
XHVDNUGMYNEUDS
|
8.3 | pIC50 | 2 | Yes | |
VJPOWWGOZASADR
|
8.3 | IC50 | 2 | — | |
ZJWIQVGGKBBVCV
|
8.3 | IC50 | 2 | — | |
APHSPKWGAGCFBE
|
8.3 | pIC50 | 2 | Yes | |
BCFGMOOMADDAQU
|
8.3 | pIC50 | 6 | Yes | |
BFSRTTWIPACGMI
|
8.3 | IC50 | 4 | — | |
BZUIGXZUUGQBLL
|
8.3 | pIC50 | 2 | Yes | |
DXHVWHPBMGIYNQ
|
8.3 | pIC50 | 2 | Yes | |
GNIFAULXFNJRKN
|
8.3 | IC50 | 4 | — | |
HVQOGQMHKMILNW
|
8.3 | IC50 | 2 | — | |
JRYLIHMRXPLXCQ
|
8.3 | IC50 | 2 | — | |
KZBKXMGIJLJPHP
|
8.3 | IC50 | 2 | — | |
LVTYOFSQYNYQPE
|
8.3 | IC50 | 2 | — | |
LXGQRZKYRSBDJV
|
8.3 | IC50 | 2 | — | |
MCVGYROQTOADFC
|
8.3 | IC50 | 2 | — | |
MFBTVPWNHQVGPL
|
8.3 | pIC50 | 2 | Yes | |
OMVRJIWYIOEXTO
|
8.3 | IC50 | 3 | — | |
SCOVLRMEIYKGOU
|
8.3 | pIC50 | 6 | Yes | |
VLUAXQQDRZDFOF
|
8.3 | pIC50 | 3 | Yes | |
VQXONFAAUSCWAP
|
8.3 | pIC50 | 2 | Yes | |
YDJAXPJDHWQNLF
|
8.3 | pIC50 | 3 | Yes | |
CMMUJJHJYMYOJR
|
8.3 | IC50 | 4 | — | |
FESKVIPHVGGMNZ
|
8.3 | IC50 | 2 | — | |
LPFWVDIFUFFKJU
|
8.3 | IC50 | 9 | — | |
YEFHSMFHMAUOIV
|
8.3 | IC50 | 2 | — | |
DUPJQTWIYRCOHX
|
8.3 | IC50 | 4 | — | |
BVBMTEPFJRTLEL
|
8.3 | IC50 | 2 | — | |
CNXHOAZFQVBOGX
|
8.3 | IC50 | 2 | — | |
CNXHOAZFQVBOGX
|
8.3 | IC50 | 2 | — | |
DVMHTSWRXUQGTL
|
8.3 | IC50 | 2 | — | |
QYRNHUOFBYAKEW
|
8.3 | IC50 | 2 | — | |
SADXACCFNXBCFY
|
8.3 | IC50 | 3 | — |