Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SUBNLERWESOYMX
|
8.5 | IC50 | 4 | Yes | |
VNEFCFHQBJYUGZ
|
8.5 | IC50 | 2 | — | |
ZITZYNQSTDWKGI
|
8.4 | IC50 | 2 | — | |
BGPAHUNSGVWHIG
|
8.4 | IC50 | 2 | — | |
IFUPZYWAOYZTHS
|
8.4 | IC50 | 2 | — | |
RSAVYUKMYLHWGE
|
8.4 | pIC50 | 2 | Yes | |
YJJIOYPSLPQCAL
|
8.4 | pIC50 | 2 | Yes | |
YXBJKXUKIDUKIH
|
8.4 | IC50 | 2 | — | |
BQKAPRHCWWQTIM
|
8.4 | IC50 | 2 | — | |
JPUWTGYAJVCPPC
|
8.4 | IC50 | 2 | — | |
RXCJZPBISMXQDN
|
8.4 | IC50 | 3 | — | |
WUOFCZPJKYPFBV
|
8.4 | IC50 | 3 | — | |
YDWRFDRHSNTINI
|
8.4 | IC50 | 2 | — | |
YVFMRJUBTQDNSA
|
8.4 | IC50 | 2 | — | |
FQSNZGGDFVIKEV
|
8.4 | IC50 | 4 | Yes | |
MWZFXIKIYVTOEE
|
8.4 | IC50 | 2 | — | |
ORFZAATXNNRFKP
|
8.4 | IC50 | 2 | — | |
SSAKQDBVDKDWIF
|
8.4 | IC50 | 3 | — | |
YLTJCMLZAIRVFF
|
8.4 | IC50 | 2 | — | |
ZZKJYWJMKZJTKA
|
8.4 | IC50 | 2 | — | |
ATEQNOXHLBHSBB
|
8.4 | pIC50 | 2 | Yes | |
BDAGXNDEGWLAME
|
8.4 | IC50 | 2 | — | |
BERLNDGSHCXVKP
|
8.4 | IC50 | 2 | — | |
BREQYZAUXDTBIU
|
8.4 | IC50 | 2 | — | |
BTVYACKHYXUQPH
|
8.4 | IC50 | 2 | — | |
BVXBBIZFISJCMB
|
8.4 | IC50 | 2 | — | |
CNRMVFRKCDVXKW
|
8.4 | IC50 | 3 | — | |
CREMXLIEDCOOOC
|
8.4 | pIC50 | 2 | Yes | |
DJURWFMQIHTKEM
|
8.4 | IC50 | 2 | — | |
FSLXKEXZBLOCTL
|
8.4 | IC50 | 2 | — | |
KFBKCZIAECRELC
|
8.4 | pIC50 | 2 | Yes | |
NFMGZVPRGVERNN
|
8.4 | Ki | 44 | — | |
SFZSLQNVKFDVLY
|
8.4 | pIC50 | 2 | Yes | |
SRUYMJRFVGLQDV
|
8.4 | Ki | 37 | — | |
XXKKLMVAVKRRTQ
|
8.4 | Ki | 2 | — | |
YSXGNIUKUJNNPR
|
8.4 | IC50 | 2 | — | |
ZZCPVBCYUULJEG
|
8.4 | IC50 | 2 | — | |
CFKLRZPAONERNA
|
8.4 | IC50 | 2 | — | |
SEXLNNKPTDAAAL
|
8.4 | IC50 | 2 | — | |
YYNUBPUXFJKWOK
|
8.4 | IC50 | 4 | — | |
ZYLWPLCMORTKOJ
|
8.4 | IC50 | 2 | — | |
FRQKYYNHZICJDA
|
8.4 | IC50 | 3 | — | |
PINKRWLMLPSIJO
|
8.4 | IC50 | 2 | — | |
UMWZSZYWDMVROC
|
8.4 | pIC50 | 3 | Yes | |
ZRNZTAHFNDWRTI
|
8.4 | IC50 | 2 | — | |
BJQBLOLTVCVLLZ
|
8.4 | Ki | 2 | — | |
HKPCGWWALFPRSS
|
8.4 | IC50 | 2 | — | |
JFUDQORFBVGLMB
|
8.4 | IC50 | 3 | — | |
KMYIIKJBSIFOEE
|
8.4 | IC50 | 2 | — | |
RTBFVYBTGAGBSP
|
8.4 | IC50 | 3 | Yes |