Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NVVASLWKXTZLJN
|
8.6 | pIC50 | 3 | Yes | |
SABXXXTUFOTOBE
|
8.6 | IC50 | 2 | — | |
SEVJDSZXBNRDKI
|
8.6 | IC50 | 2 | — | |
UUAOWKSAEYOOIY
|
8.6 | IC50 | 2 | — | |
VEQYCEHJTJSHLO
|
8.6 | IC50 | 4 | — | |
XAHNKMWYZJATAR
|
8.6 | IC50 | 2 | — | |
DWLVUAOJOFAURW
|
8.5 | pIC50 | 3 | Yes | |
FHOMWNVSSMYQJF
|
8.5 | IC50 | 2 | — | |
OFQRNJAHCAMAME
|
8.5 | IC50 | 2 | — | |
PHBABPPOPBBETK
|
8.5 | IC50 | 2 | — | |
RENFOOCUNGUUHO
|
8.5 | IC50 | 2 | — | |
RSJIZNRDILNEMO
|
8.5 | IC50 | 2 | — | |
WVPWMTUOJRIZIV
|
8.5 | IC50 | 2 | — | |
ARFRDHRNFVIREW
|
8.5 | IC50 | 2 | — | |
FTFRZXFNZVCRSK
|
8.5 | pIC50 | 2 | Yes | |
GYCAMAWPCOYTTF
|
8.5 | pIC50 | 2 | Yes | |
HXMKNGQXLJHQDQ
|
8.5 | pIC50 | 2 | Yes | |
JNCKWWADGCZZGL
|
8.5 | pIC50 | 2 | Yes | |
MNHSNOFOOBXMPN
|
8.5 | IC50 | 2 | — | |
MVZGYPSXNDCANY
|
8.5 | IC50 | 3 | — | |
NWDHKEKOJHPRMD
|
8.5 | IC50 | 2 | — | |
NXSMOWZBERTEAU
|
8.5 | pIC50 | 2 | Yes | |
OIPWVAYMLKMQOR
|
8.5 | IC50 | 2 | — | |
OUQSQZRPYOPTCZ
|
8.5 | IC50 | 2 | — | |
QQUJEUGNKCSQPP
|
8.5 | Ki | 2 | — | |
RAKHTNLGXMUAQG
|
8.5 | pIC50 | 2 | Yes | |
WWVSQNVNUAFENV
|
8.5 | pIC50 | 2 | Yes | |
YJEHFTZFENYBBO
|
8.5 | pIC50 | 2 | Yes | |
CUVXNXWOSLVJIM
|
8.5 | IC50 | 2 | — | |
FQGVUAQWOXXERW
|
8.5 | pIC50 | 3 | Yes | |
KTOOFDBYBSZFDL
|
8.5 | IC50 | 3 | — | |
QTRVZMFRXOALDJ
|
8.5 | pIC50 | 3 | Yes | |
RQYVKBOWLRVISJ
|
8.5 | pIC50 | 14 | Yes | |
UJBJAMOSBBJZBK
|
8.5 | pIC50 | 6 | Yes | |
ZHGLJJSISHRVHL
|
8.5 | IC50 | 3 | — | |
AZSRSNUQCUDCGG
|
8.5 | IC50 | 4 | — | |
BKAWDVUEVXFMOR
|
8.5 | IC50 | 2 | — | |
FWRVTLDCKFPGCK
|
8.5 | IC50 | 2 | — | |
FXRLTQRMUHOCQN
|
8.5 | IC50 | 4 | — | |
NLSULBLCONKOIY
|
8.5 | IC50 | 2 | — | |
BQKAPRHCWWQTIM
|
8.5 | IC50 | 2 | — | |
CADRLZXVKIQPSG
|
8.5 | pIC50 | 13 | Yes | |
RENFOOCUNGUUHO
|
8.5 | IC50 | 2 | — | |
SIMOEFIOKHUVBO
|
8.5 | Ki | 2 | — | |
ALZWUAVTIXIKIX
|
8.5 | IC50 | 3 | — | |
ATUXFPJRTSKHFB
|
8.5 | IC50 | 3 | — | |
CPKOOPNFOWNEFT
|
8.5 | IC50 | 2 | — | |
LGOLZSGPACQCPU
|
8.5 | IC50 | 2 | — | |
OONFNUWBHFSNBT
|
8.5 | IC50 | 11 | — | |
RWQRIUWKYIAJRI
|
8.5 | IC50 | 2 | — |