Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MTXGVGJDJNQPCL
|
8.7 | IC50 | 2 | — | |
PKKRQPPSMXAKFM
|
8.7 | pIC50 | 3 | Yes | |
GSSHFNOWTLFACP
|
8.7 | IC50 | 2 | — | |
PCOFCPRYWPQQMW
|
8.7 | IC50 | 2 | — | |
ZNRSOAIMVVRTJR
|
8.7 | IC50 | 2 | — | |
DYWKHZDUSFUFCP
|
8.7 | IC50 | 3 | — | |
GCUYIMVZVRRUPD
|
8.7 | IC50 | 3 | — | |
IHZHFIKEGVXLHF
|
8.7 | pIC50 | 2 | Yes | |
IQNVEOMHJHBNHC
|
8.7 | IC50 | 2 | — | |
IXWWFHBAOSNFBD
|
8.7 | pIC50 | 13 | Yes | |
OBPBWDICVLAZAK
|
8.7 | Ki | 2 | — | |
RRBYOZUVIOQSSM
|
8.7 | pIC50 | 2 | Yes | |
SVRFIUCPQRDGOA
|
8.7 | IC50 | 2 | — | |
UWXSAYUXVSFDBQ
|
8.7 | IC50 | 6 | — | |
VEUPQFZZGZKGQD
|
8.7 | IC50 | 3 | — | |
ZMYUKKKHJVNBAM
|
8.7 | IC50 | 5 | Yes | |
ZROBAJVGRYCCGH
|
8.7 | pIC50 | 2 | Yes | |
HNFWPMOZPVUYBB
|
8.7 | IC50 | 4 | — | |
NXBDRZNDPDCAAE
|
8.7 | IC50 | 2 | — | |
OSBNTMYQLUCHOK
|
8.7 | IC50 | 2 | — | |
PXGDIYNZVLBJPI
|
8.7 | IC50 | 2 | — | |
QZLBUBDMRGKXON
|
8.7 | IC50 | 2 | — | |
SNGQUXXOIHSAPK
|
8.7 | pIC50 | 13 | Yes | |
YGVOTPAIXFJINL
|
8.7 | IC50 | 2 | — | |
MHRLVGRDCBMEMM
|
8.7 | IC50 | 2 | — | |
DNZYOZKYEXTOPJ
|
8.7 | pIC50 | 16 | Yes | |
GQTMXLIHJOTTCN
|
8.7 | IC50 | 2 | — | |
SEHAPCZLZSSPLF
|
8.7 | IC50 | 2 | — | |
XRKMXTSLBXGSQT
|
8.7 | IC50 | 2 | — | |
HYMYAHJTTZILBA
|
8.6 | IC50 | 2 | — | |
BBIKEXVBWCYZFP
|
8.6 | pIC50 | 2 | Yes | |
GTVAUPIBHVDGDF
|
8.6 | IC50 | 2 | — | |
HGURWXVQNCHCIP
|
8.6 | IC50 | 2 | — | |
ADKLWTJYNHIZGI
|
8.6 | IC50 | 2 | — | |
GSDQZJWVOBCWHP
|
8.6 | IC50 | 2 | — | |
PBOJUVGISNLNHX
|
8.6 | IC50 | 2 | — | |
PUKITJOCVOEXLY
|
8.6 | IC50 | 2 | — | |
QIGGJMQSVPHSJB
|
8.6 | pIC50 | 16 | Yes | |
VAMWYDFGORHXIU
|
8.6 | IC50 | 2 | — | |
CESQHIFBQQEBBM
|
8.6 | IC50 | 2 | — | |
LRPCGYUQHZRYLM
|
8.6 | IC50 | 2 | — | |
NKHMICLDWIUZLX
|
8.6 | Kd | 2 | — | |
NOTKEBYHDOJLEM
|
8.6 | IC50 | 2 | — | |
YAPFODKXVWEFPW
|
8.6 | IC50 | 3 | — | |
DILPWWRXPRYDEA
|
8.6 | IC50 | 2 | — | |
WBAMFNDJQOEJFN
|
8.6 | Ki | 2 | — | |
NXVZNVMICNOVJM
|
8.6 | IC50 | 2 | — | |
DJAUDRYHVNOPNC
|
8.6 | IC50 | 2 | — | |
FNFNGVSJMJREKW
|
8.6 | pIC50 | 2 | Yes | |
GNBZJTFEESJZBO
|
8.6 | IC50 | 2 | — |