Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
GCDSDVNITVBCDW
|
9.0 | IC50 | 17 | — | |
GOWVVIDXCJWUFJ
|
9.0 | pIC50 | 2 | Yes | |
ROHJEIACUNTGFP
|
9.0 | IC50 | 16 | — | |
UIKHYQLSZPHCKO
|
9.0 | IC50 | 2 | — | |
UMBIRSZUCJNBHB
|
9.0 | IC50 | 18 | — | |
XYUIVHYWMAPVBZ
|
9.0 | pIC50 | 2 | Yes | |
RKUXMYUMMSWVGH
|
9.0 | IC50 | 2 | — | |
IDQAZRHOHYFAOQ
|
9.0 | pIC50 | 2 | Yes | |
PXBVPDIMCOILPS
|
9.0 | pIC50 | 3 | Yes | |
HRLHWOFWUMHHIP
|
8.9 | pIC50 | 2 | Yes | |
KZBKXMGIJLJPHP
|
8.9 | IC50 | 2 | — | |
ZAWWCTXYZTURLN
|
8.9 | IC50 | 4 | — | |
JJHXVSSJRMTBMC
|
8.9 | pIC50 | 3 | Yes | |
OWTUZFHMSVAQSQ
|
8.9 | Ki | 2 | — | |
SXHXSFDRRRWGRB
|
8.9 | IC50 | 2 | — | |
LFINNXTUHOXVQV
|
8.8 | IC50 | 2 | — | |
LHHLPNVJMCVRGH
|
8.8 | IC50 | 2 | — | |
LYIUENVBACZSCL
|
8.8 | IC50 | 2 | — | |
TVQHGTHLBVLBIA
|
8.8 | pIC50 | 3 | Yes | |
WAYSVGLDKMEZLH
|
8.8 | IC50 | 2 | — | |
XKPNZYKHLRMXRP
|
8.8 | IC50 | 2 | — | |
HGQXZYPOEYQQSH
|
8.8 | IC50 | 2 | — | |
OMZCMEYTWSXEPZ
|
8.8 | pIC50 | 43 | Yes | |
OVKAWEPHUVGRCJ
|
8.8 | IC50 | 2 | — | |
WUTKDVWWIGSHGA
|
8.8 | pIC50 | 2 | Yes | |
MIHHASRXEFINIJ
|
8.8 | IC50 | 2 | — | |
YBNQRDJFYLHMJK
|
8.8 | IC50 | 2 | — | |
AAGKMGNYUYCEPD
|
8.8 | IC50 | 2 | — | |
IREADPMWGRIVEJ
|
8.8 | IC50 | 2 | — | |
KYLTYWRKNDUYIL
|
8.8 | IC50 | 2 | — | |
LLDLKTHXNUZVDV
|
8.8 | IC50 | 2 | — | |
RHNCTEJANSMRNV
|
8.8 | pIC50 | 3 | Yes | |
RZPOCZHUFDCVQZ
|
8.8 | pIC50 | 2 | Yes | |
SHKHWNUDFOMKAK
|
8.8 | IC50 | 2 | — | |
WNGDCEKCMKAXBU
|
8.8 | Ki | 2 | — | |
WZZXMNBOPNKKSX
|
8.8 | Ki | 10 | — | |
YFFQYUIFTHZMHX
|
8.8 | IC50 | 2 | — | |
CRLFCKNBDNTEBA
|
8.8 | IC50 | 2 | — | |
RCXKACUHTAVIBD
|
8.8 | IC50 | 2 | — | |
YJAJTLZIWHYGPF
|
8.8 | IC50 | 3 | — | |
AJCVQFHDDPYHTQ
|
8.8 | IC50 | 2 | — | |
GSQLJRMAXJKBMR
|
8.8 | IC50 | 2 | — | |
IMLBZWHQWRDARS
|
8.8 | IC50 | 4 | — | |
ISEHGRGNSOYPTL
|
8.8 | pIC50 | 3 | Yes | |
OETCDAITXCDXIB
|
8.8 | pIC50 | 3 | Yes | |
RBVREWVCSCUBOY
|
8.8 | IC50 | 2 | — | |
WEKWLJJTCAFJDA
|
8.8 | IC50 | 2 | — | |
ZJLGUUXMOOWUTC
|
8.8 | IC50 | 2 | — | |
AHRFAYIIMKQRQN
|
8.7 | pIC50 | 2 | Yes | |
HMFQGZQQOSIJND
|
8.7 | IC50 | 2 | — |