Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XCIKLSSUHGYTCI
|
7.8 | pIC50 | 2 | Yes | |
XLSRHUQCTDISSD
|
7.8 | Ki | 2 | — | |
ZYQXEVJIFYIBHZ
|
7.8 | IC50 | 5 | — | |
QTDAKIJYNHGZGQ
|
7.8 | IC50 | 2 | — | |
UBWUGVUBMOLCSK
|
7.8 | IC50 | 2 | — | |
UBWUGVUBMOLCSK
|
7.8 | IC50 | 2 | — | |
YYQSQLGNBWMYFW
|
7.8 | IC50 | 2 | — | |
BHZWACACNOOTKB
|
7.7 | IC50 | 2 | — | |
BYMFSZLMPVZBJV
|
7.7 | Ki | 4 | — | |
GYDNMCFYNSRRTC
|
7.7 | pIC50 | 2 | Yes | |
HJVYBTQSZTWFII
|
7.7 | pIC50 | 2 | Yes | |
IRPQLCLTIKGBTQ
|
7.7 | pIC50 | 2 | Yes | |
JTLHPKSZESHKCP
|
7.7 | IC50 | 4 | Yes | |
LOTDTZWETDFBTC
|
7.7 | IC50 | 2 | — | |
MBAKBFMFUHKHAN
|
7.7 | pIC50 | 2 | Yes | |
OEIFFQPPBJFHDE
|
7.7 | IC50 | 2 | — | |
PDHPVHXAEDIWBQ
|
7.7 | IC50 | 2 | — | |
QKLWVDQKXUTTEU
|
7.7 | IC50 | 2 | — | |
RHSAUGZCZKFNLC
|
7.7 | IC50 | 2 | — | |
SPGSQKKTHWOODB
|
7.7 | IC50 | 4 | Yes | |
SVDARJHLGCNCRG
|
7.7 | IC50 | 2 | — | |
XJKTUTUQMCPTDY
|
7.7 | IC50 | 2 | — | |
XYSQNPURJDRMJW
|
7.7 | IC50 | 2 | — | |
YJXDRUZZNZTVEI
|
7.7 | Ki | 2 | — | |
ZJXFDKWJAGZFLT
|
7.7 | pIC50 | 2 | Yes | |
SBUKWLYIXVGAMU
|
7.7 | IC50 | 2 | — | |
AQEJOYTVPDGMEW
|
7.7 | IC50 | 3 | — | |
BGXFUKVIYBKVKN
|
7.7 | IC50 | 2 | — | |
BIHYRPIDCXHQKD
|
7.7 | IC50 | 3 | — | |
BROYMMFRLLTITA
|
7.7 | Ki | 2 | — | |
BTWVWABAWDKQNJ
|
7.7 | IC50 | 8 | — | |
HVJQYIDZJSEHCZ
|
7.7 | pIC50 | 2 | Yes | |
MTHDVQYDQJZAFB
|
7.7 | pIC50 | 2 | Yes | |
NFXTTXHMQKNZQL
|
7.7 | IC50 | 2 | — | |
NXQXZOZVAHCESP
|
7.7 | pIC50 | 2 | Yes | |
NYCRPERPKUAEHF
|
7.7 | IC50 | 3 | — | |
PDXFYKHCQHPMFZ
|
7.7 | IC50 | 2 | — | |
POJRAIDOFSJODM
|
7.7 | IC50 | 2 | — | |
QUOQTGPAFKSIQB
|
7.7 | Ki | 2 | — | |
SXQLWNOERMLQGM
|
7.7 | pIC50 | 3 | Yes | |
UCBARNSJTRWXQT
|
7.7 | IC50 | 3 | — | |
WTCWMZHEAXFWPJ
|
7.7 | IC50 | 4 | — | |
YLFPZRPXZQPKNI
|
7.7 | pIC50 | 2 | Yes | |
ZAJXXUDARPGGOC
|
7.7 | IC50 | 4 | — | |
HXABMNJIMMNPOH
|
7.7 | IC50 | 2 | — | |
NQWIUICVKCCZCN
|
7.7 | IC50 | 2 | — | |
UYDBMGZYANVBCS
|
7.7 | IC50 | 2 | — | |
ZOLXJDSFGCNIAL
|
7.7 | IC50 | 2 | — | |
AZLXGJFHSLQCPV
|
7.7 | IC50 | 2 | — | |
CQCHWVJIDPPZIH
|
7.7 | IC50 | 2 | — |