Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZIETVRSYZYJSDW
|
7.8 | IC50 | 2 | — | |
HPDCTDQLVVUMGU
|
7.8 | IC50 | 2 | — | |
ICKLZZYEDMBELM
|
7.8 | IC50 | 2 | — | |
KYAXDNMYCYBVHP
|
7.8 | IC50 | 2 | — | |
QMOJTBYMFQXLLU
|
7.8 | pIC50 | 6 | Yes | |
XAHNKMWYZJATAR
|
7.8 | IC50 | 2 | — | |
AMKFBXVTNZFKFF
|
7.8 | IC50 | 4 | — | |
ATEKSUDRIVWTTK
|
7.8 | IC50 | 4 | — | |
BPMVYYLSRDJWNL
|
7.8 | Ki | 2 | — | |
BTMKEDDEMKKSEF
|
7.8 | IC50 | 2 | — | |
DFGKFQWBYFTPQH
|
7.8 | IC50 | 2 | — | |
DFPVBLYULSUJRC
|
7.8 | pIC50 | 2 | Yes | |
DVUATEKKQZRNJW
|
7.8 | pIC50 | 2 | Yes | |
FUCZYDBKFNOERW
|
7.8 | IC50 | 3 | — | |
HYWZCMMMRGRRRF
|
7.8 | pIC50 | 2 | Yes | |
JCMIPNLNEAFFHI
|
7.8 | IC50 | 2 | — | |
JIGUCXPMOHEAMU
|
7.8 | IC50 | 2 | — | |
LAAGQYGQCANRRA
|
7.8 | IC50 | 2 | — | |
LAAGQYGQCANRRA
|
7.8 | IC50 | 2 | — | |
LLRHFPTXSRUXGC
|
7.8 | IC50 | 2 | — | |
LTZADKANMDZUFP
|
7.8 | pIC50 | 2 | Yes | |
MMNBFIZFTKJPBY
|
7.8 | IC50 | 2 | — | |
PLIVFNIUGLLCEK
|
7.8 | IC50 | 20 | Yes | |
QAIGLWIBJKERDJ
|
7.8 | IC50 | 2 | — | |
QLLLIGGXRUNRDR
|
7.8 | pIC50 | 2 | Yes | |
QXBRLYYVUXFWHN
|
7.8 | IC50 | 2 | — | |
RFXHNJBBKBSDIB
|
7.8 | IC50 | 2 | — | |
RULQLIYSPUITNW
|
7.8 | Ki | 2 | — | |
SKBWQUPLWQUWPH
|
7.8 | pIC50 | 6 | Yes | |
SXIHCMNTCWRRMW
|
7.8 | IC50 | 2 | — | |
VNEFCFHQBJYUGZ
|
7.8 | IC50 | 2 | — | |
ZXNLHZGFHDHRCO
|
7.8 | IC50 | 4 | — | |
AJAQFZXSPHGXPW
|
7.8 | IC50 | 2 | — | |
IOMMMLWIABWRKL
|
7.8 | IC50 | 2 | — | |
ODMXWZROLKITMS
|
7.8 | IC50 | 3 | — | |
AZDCMGDGNHSVCZ
|
7.8 | pIC50 | 2 | Yes | |
CONZRYUIXZKOIG
|
7.8 | IC50 | 2 | — | |
FHQQNAHMJMQUKJ
|
7.8 | IC50 | 4 | Yes | |
GCMJIBUKSLVDKY
|
7.8 | IC50 | 2 | — | |
GHQPLJWMCNPRIH
|
7.8 | pIC50 | 3 | Yes | |
JLWZRGNJHZVVKD
|
7.8 | IC50 | 3 | — | |
MPSMEEDGQBLMNI
|
7.8 | pIC50 | 2 | Yes | |
QFMCOTDYFYKZNH
|
7.8 | IC50 | 4 | — | |
QGZVSVHWQCGWDX
|
7.8 | IC50 | 3 | — | |
QQDKYSNDWYIWJF
|
7.8 | pIC50 | 2 | Yes | |
RFABPKSSVXQXLK
|
7.8 | IC50 | 2 | — | |
RFABPKSSVXQXLK
|
7.8 | IC50 | 2 | — | |
RMKXHEPYDGCAAP
|
7.8 | Ki | 2 | — | |
RMPVKBBFQRDYJT
|
7.8 | IC50 | 2 | — | |
VMDUWDNQTGHKSN
|
7.8 | IC50 | 2 | — |