Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
TXIRDIAXSNWNPA
|
7.9 | pIC50 | 2 | Yes | |
VPPDBLLRRNCUSU
|
7.9 | pIC50 | 13 | Yes | |
WUPUQIUJIDRWAX
|
7.9 | IC50 | 2 | — | |
YAWRCBHLRDCILP
|
7.9 | IC50 | 2 | — | |
ZCDHAHOTIYZFKF
|
7.9 | pIC50 | 7 | Yes | |
ZNCRTOWCSZYNSA
|
7.9 | Ki | 2 | — | |
BBULYYFEVOCODO
|
7.9 | IC50 | 2 | — | |
KYIOPHOSYULFRB
|
7.9 | IC50 | 2 | — | |
XNMHWKJRXNZELF
|
7.9 | IC50 | 2 | — | |
MDCWIVYFXQKDOP
|
7.9 | pIC50 | 2 | Yes | |
QJNMNCUMDUMIJV
|
7.9 | IC50 | 2 | — | |
JCKPXXCMARLTQI
|
7.9 | pIC50 | 6 | Yes | |
MSIRGVZSBIEYOM
|
7.9 | IC50 | 2 | — | |
SMUCRZPXLSRBNU
|
7.9 | Ki | 2 | — | |
AXVKGZLOECWENV
|
7.8 | IC50 | 2 | — | |
DFJSJLGUIXFDJP
|
7.8 | IC50 | 9 | — | |
KEAKJPADMWJACP
|
7.8 | IC50 | 2 | — | |
KYLTYWRKNDUYIL
|
7.8 | IC50 | 2 | — | |
OZWPBBYNOKRDFB
|
7.8 | IC50 | 4 | Yes | |
PXQOJJHRXWJWMU
|
7.8 | IC50 | 2 | — | |
RUEMCYBCUGHERT
|
7.8 | IC50 | 2 | — | |
SHVTYLACROTBHI
|
7.8 | Ki | 2 | — | |
TYZVQDKPFGAICT
|
7.8 | IC50 | 2 | — | |
UFLUWNRWPWDTEF
|
7.8 | pIC50 | 2 | Yes | |
ULXXDDBFHOBEHA
|
7.8 | IC50 | 2 | — | |
VBFBOJPZZPXTID
|
7.8 | pIC50 | 2 | Yes | |
YBEIPHUFRFGXCJ
|
7.8 | IC50 | 4 | — | |
ZUXMJIHRFCSCKH
|
7.8 | IC50 | 2 | — | |
ZVCRDGKVDBJYMB
|
7.8 | IC50 | 2 | — | |
ZXVPQQUYVOHTBO
|
7.8 | IC50 | 2 | — | |
FPFVOXIARGRQQR
|
7.8 | IC50 | 2 | — | |
LDLBFITVAGVRNV
|
7.8 | pIC50 | 6 | Yes | |
HJPASCBASAXJFI
|
7.8 | IC50 | 2 | — | |
JXWQISPUKBAERI
|
7.8 | IC50 | 2 | — | |
AAKJLRGGTJKAMG
|
7.8 | pIC50 | 50 | Yes | |
BWWLZGAQCJRAGF
|
7.8 | IC50 | 4 | — | |
DUYJMQONPNNFPI
|
7.8 | IC50 | 11 | — | |
FFMBLUIQUJAMEE
|
7.8 | IC50 | 2 | — | |
HKJUUPKKOAGVDB
|
7.8 | pIC50 | 6 | Yes | |
KHEXPUZMPCBDCB
|
7.8 | pIC50 | 2 | Yes | |
MCIZZPUSTVXXPG
|
7.8 | pIC50 | 3 | Yes | |
MHJBSGVISQZKDI
|
7.8 | IC50 | 4 | — | |
NREXZVOJRVRMAI
|
7.8 | IC50 | 3 | Yes | |
REGOTSLWVKSZRG
|
7.8 | IC50 | 2 | — | |
SCKUKFURRSWTCI
|
7.8 | IC50 | 2 | — | |
ULMZSUGIZVDJDK
|
7.8 | pIC50 | 2 | Yes | |
VWSBSFWOEVWTNU
|
7.8 | IC50 | 2 | — | |
YJFISNXQNZZQFP
|
7.8 | IC50 | 2 | — | |
YTSHEQYHNLLMSR
|
7.8 | pIC50 | 13 | Yes | |
ZEHMAUGAZFSJNV
|
7.8 | Ki | 2 | — |