Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XRGMUYHNNJZTJU
|
8.0 | pIC50 | 2 | Yes | |
ZTQLMGBKQNFQRU
|
8.0 | IC50 | 2 | — | |
KZBKXMGIJLJPHP
|
8.0 | IC50 | 2 | — | |
XETMUFWUKSYSBU
|
8.0 | IC50 | 2 | — | |
ZHSPHEJVKURUJP
|
8.0 | IC50 | 2 | — | |
GFNQLGINZIYPLH
|
7.9 | IC50 | 2 | — | |
OTIXNYWEVTWQKC
|
7.9 | IC50 | 2 | — | |
QHQPSUJDQJBVDH
|
7.9 | IC50 | 2 | — | |
QXHOCHWKUSXBGX
|
7.9 | IC50 | 2 | — | |
YYMXPNNILUETLE
|
7.9 | IC50 | 3 | Yes | |
GUHJZZKAWYPNAQ
|
7.9 | IC50 | 2 | — | |
QMXMLFJONMTABH
|
7.9 | IC50 | 2 | — | |
BDCAOKLPNVNFEL
|
7.9 | pIC50 | 2 | Yes | |
FGYHOZIXSUEJDM
|
7.9 | IC50 | 3 | — | |
FLFHZVYTVPANLR
|
7.9 | IC50 | 4 | — | |
GGPWWEAGMSDXFA
|
7.9 | pIC50 | 2 | Yes | |
HAZSHDZWYBFNQU
|
7.9 | IC50 | 2 | — | |
IYWCOZMVACEZGO
|
7.9 | IC50 | 2 | — | |
JFEKMLAOHVYFGS
|
7.9 | IC50 | 4 | — | |
JFOADMWQXWRMGB
|
7.9 | pIC50 | 2 | Yes | |
KHQLMFFPQINCMZ
|
7.9 | pIC50 | 2 | Yes | |
LSCYWBZWOOITKQ
|
7.9 | IC50 | 2 | — | |
MCEJMTKEBSFUJK
|
7.9 | IC50 | 4 | — | |
NLSNSCBPWXRRPL
|
7.9 | IC50 | 3 | — | |
NWZQTNDYDHXMOE
|
7.9 | IC50 | 3 | — | |
ONVVZBADBZXLMG
|
7.9 | pIC50 | 2 | Yes | |
PYTBGGBGRRJDNT
|
7.9 | pIC50 | 2 | Yes | |
QAQXTNHOYJTPGB
|
7.9 | IC50 | 7 | Yes | |
RBBZLSVNHVBMRU
|
7.9 | IC50 | 3 | — | |
RWRYVPUMPZVZSS
|
7.9 | pIC50 | 2 | Yes | |
WRXRFFUVXFNKGG
|
7.9 | IC50 | 2 | — | |
XVMMZTTYUZMATQ
|
7.9 | IC50 | 2 | — | |
YRMOQCDUODUCRH
|
7.9 | IC50 | 3 | — | |
YROLHQZDEFQCCR
|
7.9 | IC50 | 4 | — | |
JACWBHQZWVPQGV
|
7.9 | IC50 | 2 | — | |
AQJDDFRQEZZVKP
|
7.9 | IC50 | 2 | — | |
BTMKEDDEMKKSEF
|
7.9 | IC50 | 2 | — | |
FDVSOQRNTAPCHB
|
7.9 | Ki | 40 | — | |
HAIHTRCFSLFERU
|
7.9 | pIC50 | 3 | Yes | |
ODNHDWIIIOWNKM
|
7.9 | IC50 | 2 | — | |
BJSZKHZJEOKFJO
|
7.9 | IC50 | 4 | Yes | |
DGVCIMUJVPVQEX
|
7.9 | pIC50 | 2 | Yes | |
HWBDLOPOEYLRKK
|
7.9 | IC50 | 4 | — | |
IKPVHBRKTATKGA
|
7.9 | pIC50 | 2 | Yes | |
KLYDITFOXCQQER
|
7.9 | IC50 | 2 | — | |
OOWWSELYEWEGFH
|
7.9 | pIC50 | 2 | Yes | |
PXOQNEQRSUORAM
|
7.9 | pIC50 | 2 | Yes | |
QWAHCSOEUYGXDS
|
7.9 | IC50 | 4 | — | |
RPEVJAKUNSLTDG
|
7.9 | IC50 | 2 | — | |
SCSKESFIGNPXKD
|
7.9 | IC50 | 4 | — |