Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XJCBAYFIITUVDS
|
8.0 | IC50 | 2 | — | |
MSLIBSZZLAWHQM
|
8.0 | pIC50 | 2 | Yes | |
PAFOOYBINUNMGT
|
8.0 | pIC50 | 6 | Yes | |
XGALLCVXEZPNRQ
|
8.0 | pIC50 | 39 | Yes | |
ASXBFKMZPZRWDW
|
8.0 | IC50 | 3 | — | |
CPSNDIISTKABIL
|
8.0 | Ki | 2 | — | |
FQUKTXLABCFONX
|
8.0 | IC50 | 3 | Yes | |
FUAWEXVTNBAJGV
|
8.0 | IC50 | 2 | — | |
HLWNQNFLDPUOHI
|
8.0 | pIC50 | 2 | Yes | |
KWBKHNYGQSAYCE
|
8.0 | IC50 | 3 | — | |
LJOCIHRQARKISZ
|
8.0 | pIC50 | 2 | Yes | |
MNNXRVSQOABRRP
|
8.0 | pIC50 | 2 | Yes | |
SSYMKGVXLKENJR
|
8.0 | pIC50 | 2 | Yes | |
XWNXMJQZGQBBQD
|
8.0 | IC50 | 2 | — | |
ZOKDRCQALBIAIW
|
8.0 | IC50 | 2 | — | |
DPAOHEUWPLGQDY
|
8.0 | pIC50 | 4 | Yes | |
FEOPLVISXFSHGK
|
8.0 | pIC50 | 13 | Yes | |
URLYPAWCHVXIAA
|
8.0 | pIC50 | 4 | Yes | |
XXQCAOCIBBLKTR
|
8.0 | IC50 | 2 | — | |
CDIOXDOXJQDENS
|
8.0 | IC50 | 4 | Yes | |
MPDCIBAUKILEGO
|
8.0 | IC50 | 2 | — | |
OMZWCVDPIZLYMM
|
8.0 | IC50 | 2 | — | |
ZOLXNVOLRGVYNI
|
8.0 | IC50 | 2 | — | |
AYIGALYNJFDMRN
|
8.0 | IC50 | 4 | — | |
CBHNKMDPARMMCD
|
8.0 | IC50 | 2 | — | |
CYQSRZQWLBOOCC
|
8.0 | IC50 | 2 | — | |
FTBHGTXTGYLDBW
|
8.0 | IC50 | 2 | — | |
GOAJIFLFYKGQGD
|
8.0 | IC50 | 2 | — | |
GSVZKVUECPSJDL
|
8.0 | IC50 | 2 | — | |
HRIQVCCRXNQUAH
|
8.0 | IC50 | 16 | Yes | |
IWBVCRRXSCJLQC
|
8.0 | pIC50 | 2 | Yes | |
JABKEJXCSLSSEV
|
8.0 | IC50 | 3 | — | |
JCUNURGXJBYRFK
|
8.0 | pIC50 | 3 | Yes | |
JRJYBZYDJRBFTK
|
8.0 | IC50 | 3 | Yes | |
NGRPMJQQEJIEMF
|
8.0 | IC50 | 3 | — | |
NJHDYUHKGOBVKW
|
8.0 | IC50 | 2 | — | |
OLGIXZUEHWJIST
|
8.0 | IC50 | 2 | — | |
PTKRHBXNNDLRPO
|
8.0 | IC50 | 2 | — | |
QREDHZHZYAMROX
|
8.0 | IC50 | 2 | — | |
RENFOOCUNGUUHO
|
8.0 | IC50 | 2 | — | |
RSNNOUWADQQHGE
|
8.0 | IC50 | 2 | — | |
RWQIOAPAHWFTMQ
|
8.0 | IC50 | 4 | — | |
RZKSNYDZEBHGRR
|
8.0 | IC50 | 2 | — | |
SBMNMLFWVOAHCS
|
8.0 | IC50 | 2 | — | |
SUSUDFJYOFEUFG
|
8.0 | IC50 | 2 | — | |
UVBKNBPCVRBUTF
|
8.0 | IC50 | 5 | — | |
VVWOQMJGNBQWHG
|
8.0 | pIC50 | 3 | Yes | |
WLLKPDBSPXZCTG
|
8.0 | pIC50 | 2 | Yes | |
WZZXMNBOPNKKSX
|
8.0 | IC50 | 2 | — | |
XPUIECRALWERTL
|
8.0 | IC50 | 4 | — |