Target Details
| UniProt AC | P04626 |
|---|---|
| Gene Symbol | ERBB2 |
| Protein Name | Receptor tyrosine-protein kinase erbB-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 2,123
- Clinical molecules 650
- Avg pChEMBL 7.35
KEGG Pathways (24)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- HIF-1 signaling pathway
- Integrin signaling
- MAPK signaling pathway
- MicroRNAs in cancer
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Tight junction
Associated Diseases (12)
Active Molecules (2,123)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KTUFNOKKBVMGRW
|
10.2 | IC50 | 38 | Yes | |
ITQSJZWWFWDOKJ
|
10.2 | pIC50 | 5 | Yes | |
VBXDUSMRNQVJRO
|
10.2 | pIC50 | 2 | Yes | |
HTUBKQUPEREOGA
|
10.1 | pIC50 | 6 | Yes | |
XDYCDXFDVOBDOO
|
10.0 | pIC50 | 2 | Yes | |
IBVURLSKTNUMDI
|
9.8 | IC50 | 2 | — | |
DWKWPKBAUKFSKF
|
9.8 | pIC50 | 2 | Yes | |
BTYYWOYVBXILOJ
|
9.7 | pIC50 | 4 | Yes | |
ZCIXBBSRVLSRJQ
|
9.7 | pIC50 | 2 | Yes | |
WVUNYSQLFKLYNI
|
9.6 | pIC50 | 46 | Yes | |
YGFCGWOZJQMOOG
|
9.6 | pIC50 | 2 | Yes | |
DLPSDPPZXRJQOY
|
9.5 | pIC50 | 3 | Yes | |
NNFDRCGXLJTASH
|
9.5 | IC50 | 4 | — | |
JGVSJOHBWPEWKW
|
9.4 | IC50 | 2 | — | |
YXOXHAUUTIOBDA
|
9.4 | pIC50 | 3 | Yes | |
AWQLTDUXGVCRBV
|
9.4 | pIC50 | 2 | Yes | |
BQKAPRHCWWQTIM
|
9.4 | IC50 | 2 | — | |
JKAXXKYYTNYYGM
|
9.4 | pIC50 | 2 | Yes | |
ZQAIYVKPDMZOOX
|
9.3 | pIC50 | 2 | Yes | |
BGPAHUNSGVWHIG
|
9.3 | IC50 | 2 | — | |
VIANWBJPMVJZPN
|
9.3 | pIC50 | 3 | Yes | |
RCQQOUGGIYVAKT
|
9.2 | pIC50 | 2 | Yes | |
DPNQFVJNRXPIOB
|
9.2 | IC50 | 3 | — | |
JPJAUHSLJCUGAH
|
9.2 | IC50 | 4 | — | |
KNXXEFGLJICDBL
|
9.2 | pIC50 | 2 | Yes | |
OMYOVWAUIIJSPG
|
9.2 | pIC50 | 3 | Yes | |
JFCHPYHJJFGZSB
|
9.2 | pIC50 | 3 | Yes | |
LSPANGZZENHZNJ
|
9.2 | pIC50 | 10 | Yes | |
GYFAPMADUQCILZ
|
9.2 | IC50 | 5 | — | |
MXDSJQHFFDGFDK
|
9.2 | IC50 | 5 | — | |
YXFCBQUDPXMRJR
|
9.2 | pIC50 | 2 | Yes | |
KIKYDYDKITYLHU
|
9.2 | IC50 | 2 | — | |
UGWGOOAEFJICES
|
9.2 | IC50 | 2 | — | |
HIONRJFCDLKILS
|
9.1 | pIC50 | 2 | Yes | |
TYPAATJNKNDNOD
|
9.1 | pIC50 | 2 | Yes | |
KXLRVRIKQJRVCZ
|
9.1 | pIC50 | 2 | Yes | |
UIAARIUTYORWEV
|
9.1 | pIC50 | 2 | Yes | |
CIGSBJHMSOROSY
|
9.1 | pIC50 | 2 | Yes | |
IZQHULBHKPGOAP
|
9.1 | pIC50 | 2 | Yes | |
WNOFAMMMUOEJEM
|
9.1 | pIC50 | 3 | Yes | |
JPHMUYSWHKPNKF
|
9.1 | pIC50 | 2 | Yes | |
FKXXCQSSSCJHOZ
|
9.1 | pIC50 | 3 | Yes | |
FOOPCYOJMREECW
|
9.1 | IC50 | 5 | — | |
OLYVUTGQXNIQQG
|
9.0 | pIC50 | 2 | Yes | |
WUQQSPODIZWQJL
|
9.0 | IC50 | 2 | — | |
DTKYOILJQJQIHX
|
9.0 | pIC50 | 2 | Yes | |
NAUMQOWVCNOPGB
|
9.0 | IC50 | 2 | — | |
AVHNHPHSQMBYAJ
|
9.0 | IC50 | 3 | — | |
AULSSQLQADCGRT
|
9.0 | IC50 | 2 | — | |
DYYZXRCFCVDSKD
|
9.0 | pIC50 | 3 | Yes |